Duke Regional Hospital Parking and Directions Visitor Restrictions Updated visitor restrictions are in effect. Preparing for Your Visit Duke Regional Hospital is easily accessible from I-85 in Durham, North Carolina. Many outpatient procedures are performed at the nearby James E. Davis Ambulatory Surgical Center. Getting Here 3643 North Roxboro Street Durham, NC 27704 Get Directions Parking Free visitor parking is located at the front of the hospital, at the Outpatient Services entrance, and the Emergency Department entrance. Handicapped parking and facility access is also available.Free parking is also available at the James E Davis Ambulatory Surgery Center. Public Transportation Duke Regional Hospital is a stop on two public bus routes. Route 4 and route 9A and 9B both service the hospital. For more information on busing schedules, visit godurhamtransit.org.