Face masks are required at this location. If you have or suspect you have been exposed to COVID-19, take these precautions before you seek care. If you have an appointment, please view the visitor restrictions in place.

Duke Primary Care Pediatrics at Holly Springs

Type:Primary Care

Our pediatricians and pediatric nurse practitioners see your child for well-child and sick visits, immunizations, sports, and school physicals, developmental screenings, and much more. Schedule your appointment by phone or online through Duke MyChart.

Clinic Hours

8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 12:00 pm Closed
Monday - Friday 8:00 am - 5:00 pm
Saturday 8:00 am - 12:00 pm

*Note: Providers at this clinic are available on Saturdays by appointment only.

Duke Health Holly Springs
401 Irving Pkwy
Suite 230
Holly Springs, NC 27540-5301
Appointments 919-385-8850    919-385-8850 Office 919-385-8850
Fax 919-385-8874

Clinic Hours

8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 5:00 pm 8:00 am - 12:00 pm Closed
Monday - Friday 8:00 am - 5:00 pm
Saturday 8:00 am - 12:00 pm

*Note: Providers at this clinic are available on Saturdays by appointment only.

General Pediatrics

Duke Health pediatric clinics and doctors are available throughout the Triangle.

Pediatric Care

Duke Primary Care Pediatrics at Holly Springs' board-certified pediatricians, pediatric nurse practitioners, and registered nurses see newborns, children, teens, and adolescents for:

  • Well-child check-ups, annual physicals, school physicals, and sports physicals
  • Immunizations, including newborn and school-age vaccinations, and annual flu shots for children at six months of age and older
  • In-clinic testing for hearing, vision, lead, jaundice, and developmental screenings
  • Ongoing care for allergiesasthma, and other chronic conditions
  • Behavioral health evaluations for ADHD, depression, and anxiety
  • Common conditions like sore throat, cough, cold, flu, rashes, and skin conditions

Our clinic includes quiet spaces and an exam room for larger families or children with complex health needs.

Lactation Counseling

Appointments can be made with a certified lactation consultant at Duke Primary Care Sage Road Pediatrics, Duke Primary Care Heritage Pediatrics, or Durham Pediatrics at North Duke Street to share guidance on all aspects of breastfeeding and assist with breastfeeding concerns. Our clinics have private spaces for breastfeeding families.

After-Hours Care

Our triage nurses are available 24/7 for established patients by calling 919-385-8850, option 2 to answer questions and offer advice on non-life-threatening illnesses and conditions. They have access to one of our pediatric providers at all times.

If your child needs to be seen when our clinic is closed, during evening or weekend hours, Duke Urgent Care Holly Springs is on the first floor of our building (Suite 130).

Specialty Referrals

When needed, your child's pediatric provider can make referrals for specialty care with Duke's network of specialists. No matter who your child sees at Duke Health, their care will be coordinated through Duke MyChart, our electronic medical records system, which is accessible to every doctor at every Duke Health location.


Laboratory and imaging tests are conveniently located in the same building.

Our Providers

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Accepted Insurance

Duke Health contracts with most major health insurance carriers and transplant networks, including the ones listed below. Before scheduling your appointment, we strongly recommend you contact your insurance company to verify that the Duke Health location or provider you plan to visit is included in your network. Your insurance company will also be able to inform you of any co-payments, co–insurances, or deductibles that will be your responsibility. If you proceed in scheduling an appointment and your health insurance benefits do not participate with Duke, your out of pocket liability may be higher. We will contact you regarding your coverage and patient liability. If you are uninsured, learn more about our financial assistance policy.

  • Aetna Choice POS, Aetna Choice POS II
  • Aetna Elect Choice HMO, Aetna Open Access Elect Choice
  • Aetna Health Network Only, Aetna Health Network Option
  • Aetna HMO
  • Aetna Limited Benefit Insurance PPO
  • Aetna Managed Choice POS
  • Aetna Medicare Assure Plan (HMO D-SNP)
  • Aetna Medicare Eagle Plan (PPO)
  • Aetna Medicare Essential Plan (PPO)
  • Aetna Medicare Value Plan (HMO)
  • Aetna Open Access HMO, Open Access Aetna Select, Aetna Open Access Managed Choice
  • Aetna Open Choice PPO
  • Aetna PCP Coordinated POS Plan
  • Aetna Quality Point of Service (QPOS)
  • Aetna Select HMO
  • Aetna Traditional Choice
  • Aetna Voluntary Indemnity Group Plan
  • Aetna Whole Health – Duke WakeMed WKCC
  • Aetna/CVS Health
  • Ambetter of North Carolina
  • Blue Advantage
  • Blue Medicare (HMO, PPO)*
  • Blue Options (123, PPO, HSA)
  • Blue Select
  • NC State Employees Health Plan
  • *Duke HomeCare and Hospice does not participate in the plan.

  • Cigna Behavioral Health (*Limited eligibility)
  • Cigna Choice Plus
  • Cigna Connect Individual Family Plan
  • Cigna Open Access
  • Cigna Open Access Plus
  • *Please call Cigna Behavioral Heath to see if the provider is participating in your plan.

  • Duke Basic
  • Duke Select
  • Experience Health Medicare Advantage (HMO) Plan
First Health
Gateway Health Alliance
  • Halifax Physician-Hospital Organization plans*
  • *This plan is only accepted at Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, and Duke HomeCare & Hospice.

  • Humana Choice (PPO)
  • Humana Choice - Medicare Advantage (PPO)
  • Humana ChoiceCare - Medicare Advantage (PPO)
  • Humana Gold Choice - Medicare Advantage (PFFS)
  • Humana Gold Plus - Medicare Advantage (HMO)
  • Humana Medicare Advantage Group Plan - NC State Retirees
  • First Medicare Direct
  • Medicare Part A
  • Medicare Part B
MultiPlan / Private Healthcare Systems
  • AmeriHealth Caritas North Carolina
  • Carolina Complete Health
  • Healthy Blue
  • NC Medicaid Direct
  • WellCare of North Carolina
  • FAMIS*
  • Optima Family Care (Medicaid HMO in VA)*
  • Optima Individual & Family (On & Off Exchange Plans)
  • Optima Plus (PPO)
  • Optima Vantage (HMO)
  • *Duke Primary Care, Duke University Hospital, Duke Regional Hospital, and Duke Raleigh Hospital are not participating with this plan.

  • TRICARE Prime
  • TRICARE Prime Remote
  • TRICARE Select
  • AARP Medicare Advantage Plan 2 (HMO-POS)
  • AARP Medicare Complete (HMO, PPO)*
  • AARP Medicare Complete Essential (HMO)*
  • All Savers Alternate Funding
  • All Savers Fully Insured
  • United Healthcare (HMO, PPO, POS)
  • United Healthcare Charter/Charter Balance/Charter Plus
  • United Healthcare Choice/Choice Plus
  • United Healthcare Core/Core Essential
  • United Healthcare Navigate/Navigate Plus/Navigate Balanced
  • United Healthcare Option PPO
  • United Healthcare Passport Connect Choice/Choice Plus
  • United Healthcare Passport Connect Options PPO
  • United Healthcare Select/Select Plus
  • United Healthcare Shared Services - Harvard Pilgrim/UHC Options PPO Network
  • United Medical Resources (UMR)
  • *Duke HomeCare and Hospice and mental health providers do not participate with the plan.

About Us

Duke Primary Care Pediatrics at Holly Springs is located within Duke Health Holly Springs, which is conveniently located off of Hwy 55 and New Hill Road. The practice is located on the second floor of the Duke Health building on Irving Parkway. 

Preparing For Your Visit

Sick children can usually be seen on the same day. Physical exams must be scheduled in advance. Please arrive 15 minutes prior to your appointment time to complete the necessary forms.

Late Policy
We value your time and work hard to keep our clinic running on time as well. Out of respect for all our patients and our timely care of your child, if you arrive 10 minutes past your scheduled appointment time you may be asked to reschedule to the next available appointment. Courtesy phone calls are also greatly appreciated.

Vaccine Position Statement
Please review our vaccine position statement (PDF, 74KB) to ensure this pediatric practice is right for you. It is the position of Duke Primary Care to vaccinate all its patient population, as many families are legitimately concerned that unvaccinated persons put their families at risk.  If you choose not to vaccinate, we strongly encourage you to establish care with a provider who shares your vaccination philosophy. We are an active participant in the Vaccines for Children Program through the North Carolina Immunization Registry. It provides vaccines at no cost to children who might not otherwise be vaccinated because of the inability to pay.

Accessibility Services

Accessibility Services Text

We provide equal access for all people and offer a range of free accessibility services to patients and visitors who need them.

Interpreter Services

Interpreter Services Text

Free interpreter services can be provided for patients who prefer to communicate in a language other than English.


Duke Health Holly Springs
401 Irving Pkwy
Suite 230
Holly Springs, NC 27540-5301


Free, on-site parking is available.

Public Transportation

Public Transportation Text

Plan your trip to Duke Primary Care Pediatrics at Holly Springs through GoTriangle. There is no bus stop within 0.5 miles. Visit GoTriangle Access to check if you meet the ADA eligibility for the Triangle's accessible transit program.