Extensive Experience
Since its inception in 1985, Duke’s heart transplant program has performed more than 2,100 heart transplants -- a number achieved by only a handful of top-tier transplant centers across the country. According to the Organ Procurement and Transplantation Network (OPTN), we perform more heart transplants than most other centers in the country.

Better Three-Year Outcomes 
We care for some of the sickest patients in the country, many of whom would be turned away by less-experienced centers. Yet our outcomes remain strong. Our heart transplant recipients do better than the national average at three years after transplant.

We offer transplantation to people who have been turned away by other centers. Our clinical research and innovative approaches to recipient and donor selection mean we may be able to help you even if you don’t meet the standard guidelines for transplant.

New Process for Heart Transplants
Duke is a leading center for a process known as donation after cardiac death, or DCD, for heart transplants. Together with the use of a device that keeps the heart beating and viable much longer versus standard procedures, this FDA-approved advance may expand the donor pool by up to 30%.

High-Risk Applicants
We often accept people seeking a heart transplant who may be at higher-than-average risk, need multiple organ transplants, or have difficult-to-match antibodies. If you’ve been turned down by another heart transplant program, we may be able to help.

Hepatitis C Hearts
We consider accepting hearts from donors with hepatitis C. Because modern hepatitis C medications are so effective, have few side effects, and don’t interact with immune medicines that are required for heart transplant recipients, these hearts can help save lives instead of being discarded.

Hepatitis B Hearts
Duke is among a handful of U.S. institutions that consider accepting hearts from donors with hepatitis B. By vaccinating transplant recipients before transplantation and (if needed) using effective hepatitis B medications after transplant, this increases the donor pool even more, especially for those who are very sick or may have a hard time accessing high-quality organs through the usual matching process.

HIV-Positive Heart Transplants
The HOPE Act made it possible for HIV-positive donors to offer their organs to HIV-positive recipients. Duke is the only transplant center in North Carolina, and one of just a few in the nation, currently approved to perform HOPE Act donor heart transplantations.

Mechanical Circulatory Support While You Wait
Keeping you well until transplant is an important step in the process. Ventricular assist devices (VADs) often serve as a bridge to transplant. Our doctors are among the nation’s leaders in VAD development, testing, and implantation. Our program is one of the largest in the world.

We also offer short-term options like intra-aortic balloon pumps (IABPs). These devices are placed during a catheterization procedure to relieve some of the heart’s workload for about 10 days. In addition, Duke can provide extracorporeal membrane oxygenation (ECMO) and total artificial hearts -- these help support some of the very sickest people until transplant.

These devices help your body pump and oxygenate blood until a donor heart becomes available.

Helping You Through the Process
Our transplant coordinators, nurses specially trained in heart transplant care, will help you navigate the transplant process and are available to answer your questions, from the initial evaluation to preparing for surgery, recovery, and the lifelong follow-up care you’ll need. We provide educational care guides to prepare you and your family for transplant. Dedicated financial coordinators work with you one-on-one to help with the financial aspects of transplantation. 

Other Duke Resources and Support
Receiving care at Duke gives you access to a wide range of experts, should you need them. In addition to heart and other specialists, social workers, psychologists, psychiatrists, and others can help care for your mental health and emotional needs. We can also put you in touch with former Duke heart transplant recipients who have volunteered to talk with people who are starting the process.

Remote, Written Second Opinion Reports
Get a written second opinion report from a Duke Health specialist in the comfort of your home. A second opinion can confirm a diagnosis, offer a different diagnosis, provide information about the most advanced treatments available, and ensure confidence in your decisions when faced with a serious medical condition. Learn more about our remote second opinion platform and process.