If a heart transplant may be in your future, you can feel confident in choosing Duke for your care. Our heart transplant program is one of the nation’s busiest; independent data show we performed more heart transplants than most other centers in the country in 2025. Our team uses advanced techniques to match more hearts with more people who have cardiomyopathy, heart failure, congenital heart disease, and other severe heart conditions. And we have some of the shortest wait times in the region. Our goal is to help you live a longer, more fulfilling life.
Since its inception in 1985, Duke’s heart transplant program has performed more than 2,100 heart transplants -- a number achieved by only a handful of top-tier transplant centers across the country. According to the Organ Procurement and Transplantation Network (OPTN), we perform more heart transplants than most other centers in the country.
People can spend years on the transplant list waiting to be matched to a heart. Our program has some of the shortest waitlist times on the East Coast. At Duke, we pride ourselves on being resourceful and utilizing as many high-quality donor hearts as possible. That means you may get a heart much faster than you would elsewhere.
If you are interested in making an appointment for an evaluation, please ask your cardiologist to submit a referral
We offer transplantation to people who have been turned away by other centers. Our clinical research and innovative approaches to recipient and donor selection mean we may be able to help you even if you don’t meet the standard guidelines for transplant.
Duke is a leading center for a process known as donation after cardiac death, or DCD, for heart transplants. Together with the use of a device that keeps the heart beating and viable much longer versus standard procedures, this FDA-approved advance may expand the donor pool by up to 30%.
We often accept people seeking a heart transplant who may be at higher-than-average risk, need multiple organ transplants, or have difficult-to-match antibodies. If you’ve been turned down by another heart transplant program, we may be able to help.
We consider accepting hearts from donors with hepatitis C. Because modern hepatitis C medications are so effective, have few side effects, and don’t interact with immune medicines that are required for heart transplant recipients, these hearts can help save lives instead of being discarded.
Duke is among a handful of U.S. institutions that consider accepting hearts from donors with hepatitis B. By vaccinating transplant recipients before transplantation and (if needed) using effective hepatitis B medications after transplant, this increases the donor pool even more, especially for those who are very sick or may have a hard time accessing high-quality organs through the usual matching process.
The HOPE Act made it possible for HIV-positive donors to offer their organs to HIV-positive recipients. Duke is the only transplant center in North Carolina, and one of just a few in the nation, currently approved to perform HOPE Act donor heart transplantations.
Heart transplant surgery is performed at Duke University Hospital. Pre- and post-transplant appointments take place at our cardiology clinics in Durham.
Keeping you well until transplant is an important step in the process. Ventricular assist devices (VADs) often serve as a bridge to transplant. Our doctors are among the nation’s leaders in VAD development, testing, and implantation. Our program is one of the largest in the world.
We also offer short-term options like intra-aortic balloon pumps (IABPs). These devices are placed during a catheterization procedure to relieve some of the heart’s workload for about 10 days. In addition, Duke can provide extracorporeal membrane oxygenation (ECMO) and total artificial hearts -- these help support some of the very sickest people until transplant.
These devices help your body pump and oxygenate blood until a donor heart becomes available.
Our transplant coordinators, nurses specially trained in heart transplant care, will help you navigate the transplant process and are available to answer your questions, from the initial evaluation to preparing for surgery, recovery, and the lifelong follow-up care you’ll need. We provide educational care guides to prepare you and your family for transplant. Dedicated financial coordinators work with you one-on-one to help with the financial aspects of transplantation.
Receiving care at Duke gives you access to a wide range of experts, should you need them. In addition to heart and other specialists, social workers, psychologists, psychiatrists, and others can help care for your mental health and emotional needs. We can also put you in touch with former Duke heart transplant recipients who have volunteered to talk with people who are starting the process.
Our doctors are leaders in transplantation research, which gives you access to best practices and new therapies through our heart transplant programs and clinical research.
When it comes to your heart care, you want the very best. Duke University Hospital is proud of our team and the exceptional care they provide. They are why our cardiology and heart surgery program is nationally ranked and the highest-ranked program in North Carolina, according to U.S. News & World Report for 2025–2026.
