During multi-organ transplant surgery, two or more diseased organs are replaced with healthy donor organs, usually from the same donor. One organ is transplanted at a time, but during the same surgery. Multi-organ transplants are relatively rare -- just over 1,000 were performed in the U.S. in 2019. Because the risks of a multi-organ transplant are generally higher than the risks of individual transplants, they require medical expertise and advanced surgical skills that are only available at hospitals like Duke.