During multi-organ transplant surgery, two or more diseased organs are replaced with healthy donor organs, usually from the same donor. The organs are transplanted during the same surgery, one at a time. Multi-organ transplants are relatively rare -- fewer than 1,300 were performed in the U.S. in 2021. Because the risks of a multi-organ transplant are generally higher than the risks of individual transplants, they require medical expertise and advanced surgical skills that are only available at hospitals like Duke.