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Duke's liver specialists (hepatologists) are internationally known for their hepatitis research and expertise. We have been involved in the development of nearly every major new hepatitis drug and diagnostic technology in the past decade. If you are eligible, we can offer you the latest therapies through our clinical trials. We work closely with you to ensure you receive the most effective treatment for your hepatitis.

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Expert Hepatitis Care

Diagnosing Hepatitis Type
We work closely with you to identify the type of hepatitis you have -- whether it's hepatitis A, B, C, D, E, or autoimmune hepatitis. If your hepatitis is caused by a virus, we also perform advanced testing to pinpoint the genotype, meaning the particular strain of the virus. This is important to ensure you receive the most effective treatment. A treatment plan is developed based on your individual condition and symptoms. We have the expertise and understanding to know if a therapy that's in a clinical trial may be the best option for you.

Reducing Your Risk of Liver Damage
Hepatitis infection often goes undetected until liver damage is present. We work with you to reduce your risk of serious liver damage, including cirrhosis (liver scarring), liver cancer, and liver failure. If you are experiencing end-stage liver disease as a result of hepatitis, our liver cancer and liver transplant experts assess your condition and recommend the right course of action.

Our Locations

Duke Health offers locations throughout the Triangle. Find one near you.



Ultrasound images assess stiffness in your liver, which corresponds to liver scarring.


A sample of liver tissue is taken to confirm a liver diagnosis and may be used to determine if you carry a gene that increases your risk for liver scarring. These results help us develop proactive treatments for several liver diseases. 

Blood Tests

Identify hepatitis antibodies in your blood. The results help determine if you have, or have had, hepatitis. Blood tests can also determine if you can pass hepatitis on to others, and if you are immune to the infection. 

Liver Function Tests

Measure your liver’s ability to produce protein and eliminate bilirubin, a blood waste product. Liver function tests also measure enzymes that are released by liver cells as a result of liver damage or disease.

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Your treatment will be based on the type of hepatitis you have, whether it is acute or chronic, and its genotype, meaning which strain of the virus has been identified. The following therapies are available to treat hepatitis. Additional therapies and combinations may be available through our clinical trials.

Direct-Acting Antiviral Medications

Simeprevir (Olysio) and sofosbuvir (Solvadi) are a new class of antivirals that prevent the hepatitis C virus from replicating itself. Studies show they may be more effective at treating hepatitis than older antivirals. Clinical trials are underway to test new therapy combinations that include these newer medications without interferon.

Liver Transplant

If your liver has been severely damaged, you may be considered for a liver transplant. The transplant surgeon removes your damaged liver and replaces it with a healthy liver.

Best Hospital for Gastroenterology and GI Surgery in NC

Where you receive your care matters. Duke University Hospital is proud of our team and the exceptional care they provide. They are why our gastroenterology and GI surgery program is nationally ranked, and the highest-ranked program in North Carolina, according to U.S. News & World Report for 2023–2024.

Why Choose Duke

Hepatitis Specialists
Our hepatologists are gastroenterologists whose advanced training allows them to specialize in liver diseases. 

Recognized Leaders
As recognized leaders in hepatitis research and treatment, we work with all of the latest hepatitis diagnostic tools and treatments, including the latest direct acting antivirals. We educate physicians around the country to use these developments effectively.

Access to Clinical Trials
As part of the Hepatitis B Research Network, we offer you the opportunity to participate in treatment studies that may test new therapies, and help us better understand the disease. We also participate in most of the major hepatitis C research studies and offer these opportunities to you when appropriate. 

Expertise in the Latest Diagnostic Tools
We were involved in the research and development of FibroScan and were one of the first medical centers to offer this noninvasive alternative to liver biopsy. It uses ultrasound to evaluate scarring within the liver, also known as liver fibrosis, which contributes to cirrhosis.

Liver Cancer Experts
Because advanced hepatitis can progress to liver cancer, we work closely with cancer specialists to coordinate regular liver cancer screenings. If found, our experts will treat liver cancer at the earliest possible stage.

Expert Liver Transplant Program
If your hepatitis progresses to the point where a liver transplant becomes necessary, our team of hepatologists and transplant surgeons have some of the best liver transplant outcomes in the United States.