Perinatal Mood Disorders

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If you are pregnant, have just had a baby, or are thinking about expanding your family, you should know that emotional challenges are common throughout the pregnancy journey. You may feel excessively sad, worried about what the future might bring, or afraid that you’re not bonding with your baby. If you experience overwhelming feelings or changes in your mental health, Duke Health’s perinatal behavioral health team of psychologists, psychiatrists, and social workers is here to support you. It’s important to seek help early, as early intervention can minimize the impact on you and your baby.

About Perinatal Mood Disorders

Postpartum depression can start at any time after birth, though symptoms usually emerge during the first few weeks, and they may persist up to a year after your baby is born. Unlike the ‘baby blues’, postpartum depression can last for months, and interfere with your ability to care for yourself and your baby. 

Perinatal anxiety disorders involve excessive worry about health, childbirth, parenting, and the baby’s well-being. You might experience panic attacks, find yourself checking on your baby more times than necessary, or have an intense feeling of being judged by other people.

Post-traumatic stress disorder (PTSD) may occur after a traumatic childbirth experience, such as an emergency C-section or your baby being in the NICU. Sometimes past traumatic experiences may feel more overwhelming during pregnancy and the postpartum period.

We also treat depression and anxiety around fertility struggles or perinatal loss and conditions such as bipolar disorder, attention-deficit/hyperactivity disorder (ADHD), and psychosis during preconception planning, pregnancy and up to a year postpartum. Substance misuse can exacerbate perinatal behavioral health issues, and we can link you up with substance use disorder treatment, too.

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Treatment for Perinatal Mood Disorders

Together, you and your health care provider will come up with the best plan for you. Your treatment might include one or more of the following: 

Individual Psychotherapy

Duke’s therapists can use a number of different “talk therapy” approaches, including cognitive behavioral therapy, depending on your symptoms and goals.

Medication Management

Psychiatric medication such as anti-depressants can reduce symptoms and help you cope. These medicines are often safe for use during pregnancy and breastfeeding under supervision. Our psychiatry team is well-versed in the safety of medications during pregnancy and breastfeeding, helping parents make informed decisions about their treatment options.

Referral to Other Services

Depending on your needs, we can connect you to community services, including support groups and resources to help you get clothing, diapers, housing, and other necessities.

Referrals For Your Partner

Your partner may also be experiencing depression or anxiety related to the pregnancy, and we can connect them to resources in the community that can help.

Our Locations

Duke Health offers locations throughout the Triangle. Find one near you.

Why Choose Duke

Convenient Appointments
Our telehealth and in-office appointments are baby-friendly; you and your infant are welcome.

Team-Based Approach
Our perinatal mental health clinic is built on a foundation of teamwork, bringing together specialists from psychiatry, psychology, and social work to provide holistic, patient-centered care.

Trauma-Informed Care
Our team provides a safe, nonjudgmental space, recognizing the impact of trauma and personal experiences on perinatal mental health.

Multi-Disciplinary Collaboration
Every two weeks, the perinatal behavioral health team meets with colleagues from departments including obstetrics and gynecology; high-risk pregnancy care; family medicine; the Duke Fertility Center; and others to share information, ideas, and resources.

This page was medically reviewed on 05/28/2025 by