Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the leading causes of long-term liver damage in the U.S. and occurs in people who drink little or no alcohol. The condition develops slowly and may not cause any symptoms until significant liver damage occurs. Obesity, Type 2 diabetes, hypertension, sleep apnea, and high cholesterol are all risk factors for the disease. Untreated, it can lead to serious liver damage.
Metabolic dysfunction-associated steatohepatitis (MASH) -- formerly known as nonalcoholic steatohepatitis (NASH) -- occurs when MASLD progresses. It can cause liver inflammation, advanced liver scarring (cirrhosis), and liver failure. MASH is the fastest growing cause of liver cancer and leads to more liver transplants than any other liver disease.