PLUVICTO®

PLUVICTO uses radiation to seek and destroy prostate cancer cells that contain a protein called PSMA (prostate-specific-membrane antigen). After finding the PSMA protein, PLUVICTO enters the cell and releases radiation, which kills the cancer cell without attacking healthy cells. This can result in fewer side effects like nausea, vomiting, and hair loss. Studies show it can extend the lives of people with this aggressive form of prostate cancer, even in the late stages.

You may be a candidate for PLUVICTO treatment if:

• You have metastatic prostate cancer.
• Your prostate cancer continues to grow despite therapy to lower your testosterone.
• Your prostate cancer has progressed even after standard chemotherapy treatments.
• Your tumors produce large amounts of PSMA.

PSMA Pet Scan

To determine if you are a candidate for PLUVICTO, you will undergo a PSMA PET scan. First, you will receive an injection of a safe, FDA-approved radioactive tracer drug that is specially made to find PSMA-producing prostate cancer cells throughout your body. An hour later, the PET machine scans your body to create images that show whether the tumor contains the PSMA target. If it does not, PLUVICTO may not be an appropriate treatment and your doctor will discuss other options.

PLUVICTO is typically given intravenously once every six weeks for up to six treatments. An IV catheter will be placed in your arm and connected to a syringe containing the medication. The infusion will take about 10 minutes. During this time, you will also receive IV saline to ensure you are well hydrated. Because your urine will be radioactive, you will urinate in a specially-equipped bathroom after your treatment.

In the days following your infusion, you may feel tired. Because saliva glands naturally contain small amounts of PSMA, you may experience dry mouth or some gastrointestinal upset. These side effects usually lessen as the weeks progress.

Your blood will be drawn to check your labs three weeks after you receive PLUVICTO and again one week before your next treatment.

To reduce exposing others to radiation, you will need to drive yourself to appointments or sit in the backseat if someone is driving you. You should maintain at least four feet of separation from people for several days following each infusion. A radiation safety expert will meet with you after each treatment to provide more detailed instructions and answer any questions you may have.