On Monday, November 22, 2021, the providers and clinics in this building will be relocating to Duke Medical Plaza North Duke Street at 3116 N Duke St, Durham, NC 27704-2102, and this building will permanently close. If you have an appointment at one of the clinics located in this building, the clinic will contact you.

Face masks are required at this location.

If you have or suspect you have been exposed to COVID-19, take these precautions before you seek care. If you have an appointment, learn about the safety measures in place at all Duke Health locations.

Duke Health Center at Roxboro Street

Duke Health Center at Roxboro Street houses multiple Duke Health clinics. To see which providers and services are offered at these clinics, please click on the individual clinic links below.

For flu vaccines for adult patients, please call 919-490-9888 to schedule a nurse visit.

4020 N Roxboro St
Durham, NC 27704-2120

About Us

This building is located on North Roxboro Street and is about two miles north of I-85. Some appointment reminders may say our clinic is on Roxboro Road – this is incorrect. Please be sure to enter the correct street address into your GPS or call the clinic for directions prior to your appointment.

Preparing For Your Visit

Accessibility Services

We provide equal access for all people and offer a range of free accessibility services to patients and visitors who need them.

Interpreter Services

Free interpreter services can be provided for patients who prefer to communicate in a language other than English.


4020 N Roxboro St
Durham, NC 27704-2120


Free, convenient parking is available.

Public Transportation

Plan your trip to Duke Health Center at Roxboro Street through GoDurham bus routes 4, 9, 9A, and 9B. The closest bus stops are Roxboro St at Pacific Ave and Pacific Ave at Roxboro Rd. If you have trouble accessing these routes, visit GoDurham Access to check if you meet the ADA eligibility for Durham County’s accessible transit program.