Bradley Goldstein, MD, PhD

As a clinician-scientist, the goal of my current research program is to study neurogenesis and tissue renewal in the olfactory mucosa, in an effort to begin to develop strategies to prevent or treat disorders that cause olfactory damage or loss. Disorders of the sense of smell are estimated to affect more than 12% of Americans, with increased incidence in adults over 65 years, and there are presently few treatment options available. In my clinical rhinology practice, I have a particular interest in patients with smell and taste disorders. I currently function as PI of an NIH-funded basic science laboratory, using mouse models, cell culture approaches and human nasal tissue specimens. The lab utilizes multiple approaches to identify mechanisms regulating adult basal stem and progenitor cells in the olfactory epithelium, as well as olfactory tissue maintenance and renewal. Our overall goal is to understand the cellular and molecular mechanisms causing acquired human olfactory disorders, to facilitate the development of new treatments.