Chimeric Antigen Receptor (CAR) T-Cell therapy is a personalized immunotherapy that uses your own cells to fight advanced lymphomas. It may be recommended when at least two other treatments have not been effective. Duke is one of three North Carolina centers certified to administer two FDA-approved CAR T-cell therapies for non-Hodgkin lymphoma: Yescarta and Kymriah. Kymriah is also approved for treatment of leukemia in pediatric patients and young adults.