Make an Appointment
You have been seen by a Duke provider for cancer care within the last three years or you need to reschedule an appointment.

or call

919-668-6688

Anal Cancer

Duke’s colorectal specialists use the latest medical and surgical advances to detect and treat anal cancer at the earliest possible stage. We give you the personalized care you need to maximize your quality of life and your colorectal health.

Find an Anal Cancer Doctor
Matching Results
Filter Results
Filter by:
Use My Current Location
Located Near You
Loading Results
Showing of Doctors
Load More View All
×

The Best Care for Anal Cancer

The colorectal physicians and surgeons in our nationally-ranked cancer center are experienced and care for anal cancer patients every day. We continue to test new therapies -- including new ways to deliver targeted radiation therapy that spares healthy tissue. We also study genes, how they function, and their impact on health. Our goal is to provide you with more personalized anal cancer treatment options.

Our Locations

Duke Health offers locations throughout the Triangle. Find one near you.

Find a Location

Treatments for Anal Cancer

Chemotherapy and Immunotherapy

Often used first in combination with radiation, chemotherapy helps boost its effectiveness.

If you have metastatic anal cancer, chemotherapy and immunotherapy can used to help control your disease.

Abdominoperineal Resection

Because anal cancer involves the anal sphincter complex, which controls our ability to hold in a bowel movement, some patients who require surgery need an abdominoperineal resection. This involves removal of the anus and the rectum, and creation of a permanent hole called a stoma in your colon. Bowel movements will come out of the stoma, into a permanent bag. Our experts have extensive experience using minimally invasive techniques, including laparoscopic and robotic platforms, to perform this procedure with smaller incisions to help you recover more easily. 

We work closely with other Duke expert teams. Urological and gynecological-oncological surgeons can help with removal of other organs, if the cancer has spread, at the same time. Plastic and reconstructive surgeons bring in healthy tissue to cover the area removed by surgery to maximize healing of the surgical wound and recovery.

Precise Radiation Therapy

Intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) allow maximum delivery of radiation to the tumor while minimizing radiation exposure of healthy tissue and organs. A computer-driven machine moves around your body while aiming radiation beams and delivering them to the cancer from several angles. Because radiation is delivered more precisely, fewer treatments are needed.

Tests for Anal Cancer

Finding anal cancer early and obtaining an accurate diagnosis is key to your health. Several methods are used to detect and diagnose anal cancers.

Digital Rectal Exam

During this physical exam, your doctor manually checks for abnormal growths.

Internal Visual Exams

An internal exam of the anus and lower rectum will be performed using either an anoscope or proctoscope. Both are short, lighted tubes that are inserted into the rectum to view inside the body and assist in diagnosis. A biopsy may be performed during the exam to remove suspicious growths or obtain tissue to be analyzed for cancer.

Imaging Studies

Noninvasive imaging tools, including MRI, PET, and CT colonography -- also known as virtual colonoscopy -- may be used to look inside the rectum to identify tumors and polyps.

Best Cancer Hospital in North Carolina

Where you receive your cancer care is important. Duke University Hospital is proud of our team and the exceptional care they provide. They are why our cancer program is nationally ranked, and the highest-ranked program in North Carolina, according to U.S. News & World Report for 2025–2026.

Why Choose Duke

One-Day Evaluations

As a first-time patient, you will undergo a thorough, day-long evaluation and consultation. This entails you meeting with every member of your cancer team: the colorectal surgeon, the medical oncologist, and the radiation oncologists. At Duke, these teams are compromised of experts who will work together to formulate the best treatment plan for you and your needs. If there is additional imaging or work-up needed, we can frequently get these done at the same time of visit. If previous scans/work-up has been done elsewhere, we are able to obtain those results and have them interpreted by our radiologists and pathologist who are experts in anal cancer.

Targeted Radiation Treatments

Sophisticated technology allows us to better target the maximum dose of radiation directly to your cancer, while minimizing exposure and possible damage to surrounding healthy tissue. Because radiation is delivered more precisely, fewer treatments are needed.

A Nationally Ranked Program

We are a National Cancer Institute-designated Comprehensive Cancer Center and are part of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers dedicated to improving care for our patients.

Access to Our Clinical Trials

You may be eligible to participate in our ongoing clinical trials, which give you access to new targeted therapies, surgical approaches, and ways to minimize common cancer-related symptoms, all before they become widely available at other hospitals.

More Minimally Invasive Procedures

Nearly 80% of surgeries are performed via minimally invasive techniques that may include laparoscopic and robotic platforms. These less-invasive methods are used to identify and sometimes remove tumors. As a result, you’ll experience smaller wounds, less pain and scarring, and lower incidence of infection. It is also likely you'll leave the hospital sooner and recover faster.

A Team of Experienced Specialists

Our anal cancer specialists include medical oncologists, radiation oncologists, colorectal surgeons, gastroenterologists, radiologists, and pathologists. They meet with geneticists, specially-trained nurses, nutritionists, and social workers to regularly discuss your care, collect opinions, and offer coordinated surgical, medical, and follow-up care.

Support for You and Your Loved Ones

Our comprehensive cancer support services range from helping patients minimize the side effects of treatment to coping with the emotional and psychological effects of diagnosis and treatment. View all of our cancer support groups in our event calendar.

This page was medically reviewed on 03/23/2026 by
Support Duke Health research or honor a loved one with a tribute gift.