John H. Sampson, MD, PhD, MBA, MHSc
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John H. Sampson, MD, PhD, MBA, MHSc

Neurosurgeon, Spine Surgeon

Duke Health Provider question
Accepting New Patients
Call for an Appointment
Areas of Expertise
Where I See Patients
Duke Cancer Center - Durham, NC
Duke Cancer Center Brain Tumor Clinic - Durham, NC
Board Certified
American Board of Neurological Surgery, Neurological Surgery

About Me

I am a neurosurgeon and researcher who is passionate about treating patients with brain tumors and other diseases of the nervous system and spine. I decided to become a doctor after spending time working with my family practitioner and getting to know patients from visit to visit. As a clinician, I enjoy seeing that patients who have had a life-threatening disease are now living normal, healthy lives. My practice emphasizes the treatment of brain cancer, either newly diagnosed, recurrent primary, or metastatic brain tumors. I also care for patients with a wide variety of problems of the brain, spine, and peripheral nerves. We are involved with several clinical trials for all types of diseases, so treatment can include enrollment in trials of new therapeutic agents (particularly immunotherapy, vaccines, and convection-enhanced delivery). We also evaluate patients with posterior fossa tumors (e.g. acoustic neuromas or meningiomas), microvascular decompression surgery for trigeminal neuralgia and hemifacial spasm, pituitary tumors, complex skull-base tumors, radiosurgery, and other neurosurgery pathologies throughout the body, including the brain, spine, and nerves.

Current Appointments and Affiliations
Languages I Speak

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Training and Education

Board Certification
American Board of Neurological Surgery, Neurological Surgery
Neurological Intensive Care, Duke University Medical Center, 1998
Neurosurgery, Duke University Medical Center, 1991-1998
MD, University of Manitoba Faculty of Medicine (Canada), 1990
PhD, Neuro-Oncology, Duke University Medical Center, 1994-1996
MHSc, Duke University, 2007

Clinical Focus and Research

My Research Interests

My research focuses on a couple therapies: one is injected directly into the brain, so the rest of the body isn’t exposed to the therapy’s toxins; the other uses the body’s own immune system to attack the tumor, similar to vaccines. Both target only the cancerous cells while leaving the normal cells alone. I am constantly in pursuit of therapies that extend the life of my patients and offer clinical solutions to brain cancer.

Publications and Grants

Insurance Accepted

Duke Health contracts with most major health insurance carriers and transplant networks, including the ones listed below.

    • Aetna Choice POS, Aetna Choice POS II
    • Aetna Elect Choice HMO, Aetna Open Access Elect Choice
    • Aetna Health Network Only, Aetna Health Network Option
    • Aetna HMO
    • Aetna Limited Benefit Insurance PPO
    • Aetna Managed Choice POS
    • Aetna Medicare Assure Plan (HMO D-SNP)
    • Aetna Medicare Eagle Plan (PPO)
    • Aetna Medicare Essential Plan (PPO)
    • Aetna Medicare Value Plan (HMO)
    • Aetna Open Access HMO, Open Access Aetna Select, Aetna Open Access Managed Choice
    • Aetna Open Choice PPO
    • Aetna PCP Coordinated POS Plan
    • Aetna Quality Point of Service (QPOS)
    • Aetna Select HMO
    • Aetna Traditional Choice
    • Aetna Voluntary Indemnity Group Plan
    • Aetna Whole Health – Duke WakeMed WKCC
    • Aetna/CVS Health
    • Ambetter of North Carolina
    • Blue Advantage
    • Blue Medicare (HMO, PPO)*
    • Blue Options (123, PPO, HSA)
    • Blue Select
    • NC State Employees Health Plan
    • *Duke HomeCare and Hospice does not participate in the plan.

    • Cigna Behavioral Health (*Limited eligibility)
    • Cigna Choice Plus
    • Cigna Connect Individual Family Plan
    • Cigna Open Access
    • Cigna Open Access Plus
    • *Please call Cigna Behavioral Heath to see if the provider is participating in your plan.

    • Duke Basic
    • Duke Select
    • Experience Health Medicare Advantage (HMO) Plan
  • Gateway Health Alliance
  • Healthgram
    • Humana Choice (PPO)
    • Humana Choice - Medicare Advantage (PPO)
    • Humana ChoiceCare - Medicare Advantage (PPO)
    • Humana Gold Choice - Medicare Advantage (PFFS)
    • Humana Gold Plus - Medicare Advantage (HMO)
    • Humana Medicare Advantage Group Plan - NC State Retirees
  • MedCost
    • First Medicare Direct
    • Medicare Part A
    • Medicare Part B
    • AmeriHealth Caritas North Carolina
    • Carolina Complete Health
    • Healthy Blue
    • NC Medicaid Direct
    • WellCare of North Carolina
    • TRICARE Prime
    • TRICARE Prime Remote
    • TRICARE Select
    • AARP Medicare Advantage Plan 2 (HMO-POS)
    • AARP Medicare Complete (HMO, PPO)*
    • AARP Medicare Complete Essential (HMO)*
    • All Savers Alternate Funding
    • All Savers Fully Insured
    • United Healthcare (HMO, PPO, POS)
    • United Healthcare Charter/Charter Balance/Charter Plus
    • United Healthcare Choice/Choice Plus
    • United Healthcare Core/Core Essential
    • United Healthcare Navigate/Navigate Plus/Navigate Balanced
    • United Healthcare Option PPO
    • United Healthcare Passport Connect Choice/Choice Plus
    • United Healthcare Passport Connect Options PPO
    • United Healthcare Select/Select Plus
    • United Healthcare Shared Services - Harvard Pilgrim/UHC Options PPO Network
    • United Medical Resources (UMR)
    • *Duke HomeCare and Hospice and mental health providers do not participate with the plan.

Before scheduling your appointment, we strongly recommend you contact your insurance company to verify that the Duke Health location or provider you plan to visit is included in your network. Your insurance company will also be able to inform you of any co-payments, co–insurances, or deductibles that will be your responsibility. If you proceed in scheduling an appointment and your health insurance benefits do not participate with Duke, your out of pocket liability may be higher. We will contact you regarding your coverage and patient liability. If you are uninsured, learn more about our financial assistance policy.

External Relationships

This faculty member (or a member of their immediate family) has reported outside activities with the companies or institutions listed below. This information has been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts of interest.
  • Annias Immunotherapeutics, Inc.
  • Celldex
  • Centuar Bio
  • Cognos Therapeutics
  • Immunomic Therapeutics
  • Insera health
  • Istari Oncology
  • Medicenna Therapeutics
  • Myeloid TX
  • Shorla