RESTORATION - Clinical Trial
What is the Purpose of this Study?
If you choose to join this study, you will first give your permission and take part in some starting tests. These include answering questions, doing fitness checks, and completing movement tasks. After that, you will be randomly placed into one of three groups: one group will do aerobic exercise, another will receive brain stimulation called rTMS, and the third group will do both.
Each group will follow a 12-week treatment plan. After that, there will be follow-up check-ins at 12 weeks and again at 24 weeks. The entire study will last about 9 months.
Depression in patients that have had a stroke
Who Can Participate in the Study?
To take part in this study, people must be between 21 and 70 years old. They must have had a stroke sometime in the past 1 to 5 years and show signs of depression based on standard tests. They also need to have some weakness or trouble moving in one or both legs but still be able to walk on their own at a slow to moderate pace.
Participants must not be taking antidepressants, or if they are, their dose must have stayed the same for at least a month and their condition must be stable.
What is Involved?
The RESTORATION study is exploring new ways to help people with depression after a stroke. Instead of using medicine, the study is testing whether regular aerobic exercise and a brain treatment called transcranial magnetic stimulation, or TMS, might work better when used together. The goal is to find out if this combination can help people feel better and recover more fully.
Study Details
