MISO-STIM (Misophonia) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to learn more about how well a study intervention works to reduce distress caused by misophonia. This intervention combines neurostimulation and skills-based training that is designed to help people think differently.

What is the Condition Being Studied?


Who Can Participate in the Study?

Adults ages 18-55 who:

  • Have misophonia (are unable to tolerate hearing certain upsetting common sounds)
  • Become upset when hearing these sounds and have trouble calming themselves or controlling their emotions
  • Can come to Duke for the in-person study visits
  • Are able to complete 2 brain MRIs
  • Are either currently not in therapy, or started therapy more than 1 month ago
  • Do not plan to start any new medications and must keep their current medication use stable

For more information about this study, please contact the study team at jasmine.chabaan@duke.edu.

Age Group

What is Involved?

If you take part in this study, you will need to visit our clinic 9 or 10 times. Two visits will involve an MRI scan and four will involve neurostimulation. You can do the remaining 3 or 4 visits remotely (online) if you wish.

If you choose to join this study, you will get a random assignment (like a coin flip) to 1 of 2 groups:

  • Group 1: You will get active neurostimulation over the right side of the brain over 4 visits.
  • Group 2: You will get sham (meaning "not active") neurostimulation over the right side of the brain over 4 visits.

The type of neurostimulation being used in the study is repetitive transcranial magnetic stimulation [rTMS] which involves placing an electromagnetic coil over your scalp that produces very small electric currents in the part of the brain closest to the coil.

Regardless of the type of neurostimulation that you get, you’ll be taught how to think differently when upset, which is a psychological skill that has been shown to be helpful for misophonia in prior research.

You can take a brief survey online to see if you might be eligible for the study: Study Eligibility Survey

Study Details

Full Title
Using neurostimulation to accelerate change in misophonia: a pilot study
Principal Investigator
Clinical Psychologist
Protocol Number
IRB: PRO00114183
NCT: NCT06333925
Phase N/A
Enrollment Status
Open for Enrollment