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Stereotactic Radiosurgery

Precise, High-Dose Radiation Treatments

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Stereotactic radiosurgery treats benign and malignant tumors and abnormalities in the brain by delivering high doses of radiation to precisely targeted areas. Stereotactic radiosurgery shortens the overall radiation treatment time and minimizes the dose to uninvolved brain tissue. As a result, stereotactic radiosurgery can:

  • Improved quality of life.
  • Fewer side effects.
  • Improved neurocognitive outcomes when compared to whole-brain radiation therapy. This is especially important for tumors located near critical brain structures such as the brainstem and optic nerves.

Our team of specialists strives to put you at ease and give you hope, knowing that the latest, most advanced medical treatments and clinical trials are available to you.

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About Stereotactic Radiosurgery

Sophisticated 3D Imaging Guides Treatment
Stereotactic radiosurgery employs 3D imaging, including magnetic resonance imaging (MRI), to locate the brain tumor or other abnormality and define its size and shape. The images are also used to target the treatment area and plan your treatment, including the number of treatments and the dose. Typically, one to five treatments are needed. 

During treatment, a linear accelerator delivers high-energy X-rays with the highest level of precision, speed, and patient comfort. Imaging takes place during treatment. Your position is adjusted to ensure you are in exactly the correct position throughout the delivery of radiotherapy.

Maximizing Your Comfort
It is very important that you remain immobile during the procedure to ensure the precise delivery of the treatment. To maximize your comfort and ensure precision, Duke uses a custom-molded, plastic mask to immobilize your head that does not require a frame. Other devices, like the Gamma Knife, pin a head frame to the skull to immobilize patients during treatment. 

Scheduled in Combination with Other Treatments
Stereotactic radiosurgery can be timed in between or during cycles of chemotherapy, immunotherapy, or other targeted therapies. This minimizes the delay of other effective treatments that are part of your treatment plan. Your treatment team will determine the optimal timing of your therapies.

Stereotactic Body Radiation Therapy
Stereotactic radiosurgery used for body areas outside the brain is called stereotactic body radiation therapy (SBRT). It can be used to treat spine, lung, and liver tumors.

The Stereotactic Radiosurgery Process

Initial Consultation

You and your family will meet with a radiation oncologist who will review the specific benefits of using this treatment for your condition. They will explain how stereotactic radiosurgery fits into your overall treatment plan and will review the potential side effects.

Planning Session

One planning session will take place before the actual treatment. During this session, a customized plastic mask will be created to hold your head in position. The type of immobilization used depends on the location and the reason for treatment. CT and MRI scans will aid in the planning process.

Treatment Sessions

Depending on your situation, your doctor may recommend up to five treatment sessions to reduce the risk of side effects while ensuring the best outcome. Multiple treatment sessions may be recommended to treat larger tumors or to simultaneously treat multiple tumors. 

Treatment sessions last 30 to 45 minutes but may be longer, depending on the size and number of targets treated.

Our Locations

Stereotactic radiosurgery treatments are available at Duke clinics in Durham and Raleigh.

Why Choose Duke

Personalized Care
We give you the care and support you need to achieve the best possible outcome. We take the time to answer all your questions and include your family in discussions about your planning and treatments. 
 
Extra Assistance if You're Traveling to Duke
If you are traveling to Duke from beyond the area, you will work with a personal stereotactic radiosurgery coordinator who will arrange for the process to be completed in two visits over one or two weeks. We talk with you before you arrive to make sure that you understand the process and that Duke providers have the information they need to coordinate your treatment.
 
Our Expert Team
You may interact with one or more of the following team members.
  • Radiation oncologists: use radiation to treat cancer and other conditions.
  • Neurosurgeons: use surgery and radiosurgery to treat brain and spine diseases.
  • Medical oncologists: use chemotherapy, immunotherapy, and targeted therapy to treat cancer.
  • Radiation physicists and dosimetrists: assist the radiation oncologist in planning the treatment and perform quality assurance on all plans.
  • Radiation therapists: administer the treatments.
  • Nurses (RN and/or nurse practitioners): provide care during radiation treatments.
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Safety and Quality Assurance
We perform extensive quality assurance checks to ensure the accuracy and effectiveness of every treatment

Simultaneous Treatment of Multiple Brain Metastases
The Duke radiosurgery approach permits simultaneous treatment of multiple brain metastases in under thirty minutes, a feature that is unavailable at most other institutions.

Expertise and Experience
More than 400 of these complex procedures are performed annually at Duke. We treat people who may be turned away at other hospitals because their tumors are too large, too numerous, too rare, or too complex.

Internationally Recognized Team
The Duke Brain and Spine Metastasis team is an internationally recognized group, comprising thought leaders who oversee major clinical trials, guidelines, medical societies, and multi-institutional research initiatives in the United States. Our team’s skills, expertise, and compassionate, personalized bedside approach ensure we consistently deliver exceptional outcomes.

Clinical Trial Access
You may be eligible to participate in a clinical trial that is testing new radiation therapies and techniques, as well as novel drugs in combination with radiotherapy.

Best Cancer Hospital in North Carolina

Where you receive your cancer care is important. Duke University Hospital is proud of our team and the exceptional care they provide. They are why our cancer program is nationally ranked, and the highest-ranked program in North Carolina, according to U.S. News & World Report for 2025–2026.

This page was medically reviewed on 09/02/2025 by