Comprehensive Pain Management

Complementary Therapies, Medications, Interventional Procedures, and Surgical Options

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Chronic pain can keep you up at night, make it difficult to focus on daily tasks, and zap your energy. The key to lasting relief is finding the source of your pain and learning how to manage it. That’s the goal of the comprehensive pain management specialists at Duke. We use a team approach to accurately diagnose your pain type and source, and we involve the right specialists to ensure you get the comprehensive care you need.

Understanding Pain

Possible Pain Sources
Pain is your body’s way of telling you something is wrong. It can result from an injury to an organ or tissue such as a torn ligament or muscle, a disease such as arthritis or cancer, or damage to a nerve from injury, aging, disease (like diabetes), compression, or inflammation. Pain can result from a psychological condition. It can also be a disease -- not just a symptom -- that can occur when nerve cells are out of whack.

Acute Pain vs. Chronic Pain
Pain that occurs suddenly and is short-lived -- days to weeks -- is called acute pain. Persistent pain that lasts for three to six months or longer is chronic pain. It can come in intermittent waves or be a constant presence. No matter where it occurs in your body, pain can be debilitating, physically and psychologically, especially when the cause is unknown.

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Where to Get Help

Pain-Specific Clinics
Duke maintains several clinics and specialists who provide care for people with chronic pain and pain in specific areas of the body such as facial and jaw pain, back pain, and migraines. They offer treatment options tailored to specific sources and sites of pain.

Comprehensive Pain Management Clinics
Often, however, the source of your pain isn’t that clear. For example, while it may reside in your back, other factors may be at play. Duke comprehensive pain management clinics are staffed by specialists who can determine the source of your pain, assess your needs, and connect you with the resources you need to feel better faster.

A Team Approach to Managing Your Pain
Our team specializes in the disease of pain and includes anesthesiologists, physiatrists (physical medicine and rehabilitation specialists), neurologists, physical therapists, behavioral health specialists, and more. We work with you to create a personalized pain management plan.

Staying Ahead of Pain

Researching New Ways to Treat and Manage Pain
Because we are part of an academic medical center, our pain management specialists are involved in research to better understand how and why pain develops and are studying new, personalized therapies to treat pain. As a Duke patient, you may have access to these therapies through our clinical trials before they are widely available.

Proactive Pain Management
In addition to providing the full spectrum of treatment options, our comprehensive pain management clinics can help you be proactive about your pain management. That’s important if you’ve had pain episodes in the past and want to prevent them from recurring.

Pre- and Post-Surgical Pain Management
If you have an upcoming surgery, our specialists work with you to identify your pain management needs before and after your surgery and to reduce your risk of developing persistent post-surgical pain.

Diagnosing Pain

During a comprehensive evaluation, your doctor will ask questions to understand the type and location of your pain, when it began, its intensity, and how it affects your life. They will also conduct a thorough physical exam.

Tests to diagnose pain may include:

  • Blood and urine tests
  • Imaging tests such as X-rays, CT scans, and MRI scans
  • Nerve conduction tests to identify nerve damage
  • An electromyogram (EMG) to assess muscle function
Our Locations

Duke Health offers locations throughout the Triangle. Find one near you.

Complementary Therapies

Complementary therapies are often recommended alongside more traditional treatments.

Acupuncture

Fine needles are strategically placed in your skin to relieve pain.

Mental Health Support

Behavioral health specialists use cognitive behavioral therapy and counseling to help you manage depression, anxiety, and other mental conditions that can be related to chronic pain. Tools include breathing exercises, muscle relaxation techniques, pain-coping skills, and stress management.

Biofeedback

Biofeedback helps reduce your body’s automatic responses to pain (for example, muscle tension, physical expressions, fast breathing, and rapid heart rate). Electrodes attached to your body measure things like brain waves, heart rate, and muscle contractions. This helps you understand what causes these reactions and helps you learn how to better control them.

Electrical Stimulation

A TENS (transcutaneous electrical nerve stimulator) unit generates mild electrical pulses to reduce your pain. Through electrodes placed on your skin at the source of your pain for 10-15 minutes, electricity stimulates your nerves, interrupting pain signals to the brain.

Lifestyle Changes

Changes to your diet, exercise routine, and sleep habits can strengthen muscles, decrease inflammation, and reduce stress on pain areas.

Massage Therapy

Massage can help relax sore muscles, ease tension, and improve blood flow and circulation.

Meditation

Meditation can release endorphins, which are the body’s own natural pain relievers. It can also reduce stress hormones that can cause inflammation and trigger pain.

Physical Therapy

Targeted exercises can improves flexibility and strength.


Medications

Nerve Pain Medications

Nerve pain medications -- including anticonvulsants, antidepressants, and gabapentinoids -- help manage pain that originates in the nerves.

Anti-Inflammatory Medications

Non-steroidal anti-inflammatory (NSAID) medicines can range from over-the-counter to prescription-strength drugs. If those are unsuccessful, prescription medications including steroids and muscle relaxers may also be prescribed.

Opioids

Opioids block pain messages but do not correct the underlying cause your pain. Because these medications can be addictive, they are only prescribed under strict supervision.


Interventional Procedures

These minimally invasive interventional procedures may help reduce pain.

Nerve Blocks and Other Injections

Medication is injected to numb certain nerves and blocks pain signals. Steroid injections can relieve pain caused by inflamed nerves. Botox injections, trigger point injections, and joint injections may also be prescribed.

Intrathecal Pump Therapy

A surgically implanted pump releases low doses of medication into the space around the spine to reduce pain signals. This minimizes the side effects of high-dose medications and results in better pain control.

Spinal Cord Stimulation

Electrodes are implanted on your spinal cord, and a generator is implanted under the skin on the abdomen or buttocks. The generator sends electrical impulses that travel through the electrodes to block pain signals.

Peripheral Nerve Stimulation (PNS)

Small electrodes are implanted next to a peripheral nerve outside the brain or spinal cord, and a generator is implanted under the skin. Electricity from the generator travels to the electrode to block pain signals sent by the peripheral nerve.

Surgical Options

If more conservative options fail to adequately control your pain, you may be a candidate for surgery. Duke surgeons offer advanced surgical options, and we are equipped to care for the most complex patients.

Consistently Ranked Among the Nation’s Best Hospitals

Duke University Hospital is proud of our team and the exceptional care they provide. They are why we are recognized as the best hospital in North Carolina, and nationally ranked in 11 adult and 9 pediatric specialties by U.S. News & World Report for 2025–2026.

This page was medically reviewed on 08/12/2025 by