ABBV-514 monotherapy and in combo with Budigalimab/Bevacizumab in NSCLC, HNSCC, & solid tumors - Clinical Trial

What is the Purpose of this Study?

What happens in this study?

- You'll get the study medicine through an IV every 3 weeks

- Depending on your group, you might also get:

- Budigalimab (a new medicine being tested)

- Or a standard cancer medicine

- You'll give blood and urine samples

- You'll have regular CT or MRI scans to check your health

What is the Condition Being Studied?

18 years or older with Non-Small Cell Lung Cancer-(NSCLC), Head and Neck Squamous Cell Carcinoma-(HNSCC), Solid Tumors, Gastric/Esophageal, Pancreatic, High-Grade Serous Ovarian Cancer, and Triple Negative Breast Cancer

Who Can Participate in the Study?

Who can join this study?

- Adults who are 18 or older

- Have an advanced or spreading form of cancer called a solid tumor

Age Group
Adults

What is Involved?

Why is this study happening?

Doctors want to see if a new medicine called azirkitug (ABBV-514) is safe and works well for people with certain cancers that have spread. They're testing it by itself, or with other medicines like budigalimab or bevacizumab.

Study Details

Full Title
A Global First-in-Human Study in NSCLC, HNSCC, and Solid Tumors with Azirkitug (ABBV‑514) as a Single Agent and in Combination with Budigalimab or Bevacizumab (M24-410)
Principal Investigator
John H. Strickler, MD
Medical Oncologist
Protocol Number
IRB: PRO00118843
NCT: NCT05005403
Phase
Phase I
ClinicalTrials.gov
Enrollment Status
Open for Enrollment
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