MOMENTUM - Clinical Trial
What is the Purpose of this Study?
This study does not give any medicine or treatment. Instead, it includes a few short visits over about four weeks. People who join will go to the clinic up to three times.
During the first visit, they will sign forms, talk about their health history, get a physical exam, have their blood pressure checked, and give blood and urine samples without needing to fast.
For the second visit, they will take a small pill called dexamethasone at home the night before. Then they will come back to the clinic for a blood test while fasting. This test checks hormone levels.
Some people may need a third visit. If their hormone levels are high, they will give more blood and schedule a special scan of their adrenal glands.
This study is not a treatment study. It is meant to help doctors learn more about hormone levels in people with hard-to-control high blood pressure.
This study is looking at how common a health problem called endogenous hypercortisolism is in adults who have resistant hypertension. Resistant hypertension means their blood pressure stays high even though they take three or more medicines, including one that helps the body get rid of extra water. Some people may need four or more different kinds of medicine to keep their blood pressure under control.
To join the study, people must be 18 years or older and meet the rules for having resistant hypertension. People cannot join if they have certain health problems or take medicines that could affect the test results. These include things like high blood pressure only at the doctor’s office, using certain steroids recently, having serious sleep problems, drinking too much alcohol, being pregnant, using birth control pills, or having certain hormone conditions.
This study does not give any treatment. It only uses tests to find out if people with this kind of high blood pressure also have the hormone problem called endogenous hypercortisolism.
Who Can Participate in the Study?
Adults who are 18 years old or older may be able to join this study if they have resistant high blood pressure. This means their blood pressure stays high even though they take three or more medicines, including one that helps remove extra water from the body. Some people may need four or more different kinds of medicine to keep their blood pressure under control.
To join, they must be able to take a medicine called dexamethasone for testing. People with certain health problems cannot join because these problems could affect the test results. These include conditions like Cushing syndrome, congenital adrenal hyperplasia, serious sleep problems that are not treated, or recent use of steroid medicines. Women who are pregnant or taking birth control pills must meet extra rules to be part of the study.
What is Involved?
The purpose of this study is to learn how often a hormone problem called endogenous hypercortisolism happens in people who have resistant high blood pressure. This kind of blood pressure stays high even when people take several medicines. By studying this condition, scientists hope to help doctors understand it better and find ways to help patients whose blood pressure is hard to control.
Study Details
