Prospective Evaluation of Exocrine Pancreatic Insufficiency (Celiac or Suspected Celiac Disease) - Clinical Trial
What is the Purpose of this Study?
We are doing this study to find out how common it is for exocrine pancreatic insufficiency (EPI) to be present in children who have or are suspected to have celiac disease. We also want to compare different methods of testing for EPI in this study.
Exocrine Pancreatic Insufficiency in the Setting of Celiac Disease
Who Can Participate in the Study?
Children ages 0-17 who:
- Have a documented abnormal celiac serology test (elevated blood antibody levels that are associated with celiac disease)
- Are scheduled to have an upper endoscopy to get a biopsy to confirm celiac disease
- Have not started a gluten-free diet before having their diagnostic endoscopy
For more information, contact the study team at annette.babu@duke.edu.
What is Involved?
If your child choose to join this study with your permission, they will have their routine endoscopy performed to confirm whether or not they have celiac disease. This endoscopy will include endoscopic pancreatic function testing, which is also a routine, common test. Pancreatic fluid will be collected during the procedure following intravenous secretin administration. Additional research analysis will be conducted on the excess pancreatic fluid samples that would otherwise be discarded.
Study Details
