LBNP/LBPP (Study of How Air Pressure Changes Exercise Performance) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out how changes in air pressure can affect people’s exercise capacity. We want to compare how these pressure changes affect the abilities of healthy volunteers and compare their changes to those of people who are diagnosed with HFpEF (heart failure with a preserved ejection fraction, a congestive heart disease).

What is the Condition Being Studied?

The Effect of Air Pressure on Exercise Capacity

Who Can Participate in the Study?

Adults ages 30+ who:

- Are in general good health (no heart, lung, or neurological conditions)

- Are able to pedal a stationary bike

For more information about this study, contact the study team at

Age Group

What is Involved?

If you choose to join the study, you will come to our clinic for 1 visit that lasts about 3 hours.

During this visit, you will:

- Answer some questionnaires

- Have blood draws and give urine samples

- Have a small amount of radioactive medication administered to you

- Wear several noninvasive measurement devices

- Exercise on a stationary bicycle while exposed to different air pressures

We will pay study participants for their time.

To learn more about this study or to let us know that you are interested, please visit our website:

Study Details

Full Title
Blood volume redistribution in HFpEF through LBNP/LBPP and the impact on exercise performance
Principal Investigator
Protocol Number
IRB: PRO00112081
NCT: NCT05764564
Phase N/A
Enrollment Status
Open for Enrollment