SICKLE-FIT Study (Exercise for Adults with SCD) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out how see how easy or difficult it is to complete a hybrid (virtual and in-person) personalized exercise training program for older adults with sickle cell disease. The virtual training sessions will be done primarily on Zoom. This research is important to determine ways to improve movement capacity, heart health, strength, and quality of life in older adults living with sickle cell disease.

What is the Condition Being Studied?

Sickle Cell Disease in Adults

Who Can Participate in the Study?

Adults ages 40+ who:

  • Are diagnosed with sickle cell disease
  • Do not need supplemental oxygen
  • Do not use a wheelchair
  • Do not have any type of unstable heart condition

For more information about this study, please contact the study team at

Age Group

What is Involved?

If you choose to join this study, participation will involve 4 in-person visits to our clinic. The virtual exercise program lasts for 12 weeks.

In-person visits (completed every three months) include:

  • Surveys about living with sickle cell disease and motivation for exercise
  • A functional assessment of walking speed, a six-minute walk test, core strength, grip strength, and chair stands
  • Blood draws and urine collection

The virtual exercise sessions will:

  • Happen 3 days a week
  • Include a warmup, mobility/stretching, cardio, strength training, and mindfulness/yoga
  • Be scaled and personalized by a dedicated fitness instructor, which means we will provide modifications for your personal level of fitness

Study Details

Full Title
Gerofit Exercise Intervention for Older Adults with Sickle Cell Disease
Principal Investigator
Protocol Number
IRB: PRO00111833
NCT: NCT05714098
Phase Pilot
Enrollment Status
Open for Enrollment