UNC ACL PTOA: A Study of Recovery after Anterior Cruciate Ligament (ACL) Reconstruction - Clinical Trial

What is the Purpose of this Study?

We are doing this study to get a better understanding of why people are at higher risk of developing arthritis after ACL reconstruction surgery. We hope the information from this study can help improve recovery techniques and lower the risk of developing knee arthritis for people who have ACL surgery. We are partnering with UNC-Chapel Hill to do this study.

What is the Condition Being Studied?

Recovery after Anterior Cruciate Ligament (ACL) Reconstruction

Who Can Participate in the Study?

Adults and children ages 16-35 who:

  • Have an ACL tear and are planning to have ACL reconstruction surgery at Duke; OR
  • Had a previous ACL tear and reconstruction surgery and are planning to have a revision surgery at Duke

For more information about who can join this study, please contact the study team at cassandra.rhodes@duke.edu.

Age Group
Adults, Children

What is Involved?

If you choose to join this study, you will visit a study clinic at UNC one time before your surgery to have some physical assessments done for your injured leg. You will return to the UNC clinic for 4 follow-up visits at the following times: 2, 4, 6, and 12 months after your surgery. During these follow-up visits, you will:

  • Have blood draws
  • Give urine samples
  • Answer questionnaires
  • Have images (MRI and X-ray) taken of your injured knee and leg
  • Do a variety of physical movement and strength tests

We will pay you for your time on the study.

Study Details

Full Title
Biomechanical Changes Following ACL Injury that Influence PTOA
Principal Investigator
Sports Medicine Orthopaedic Surgeon
Protocol Number
IRB: PRO00111706
Phase N/A
Enrollment Status
Open for Enrollment