ALADDIN (Aging and Memory Study) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to help us identify the underlying causes of brain disorders such as delirium and/or dementia.

What is the Condition Being Studied?

Thinking and memory problems after surgery in older adults

Who Can Participate in the Study?

Adults ages 65+ who:

  • Are scheduled to have surgery in the next few months
  • Are able to speak English
  • Are able to give consent

For more information about the study, please contact the study team at

Age Group

What is Involved?

If you choose to join this study, you will:

  • Undergo memory and thinking tests and complete surveys prior to surgery and again 3 months and 1 year after surgery
  • Have a blood draw before surgery and again at 3 months and 1 year after surgery
  • Have a lumbar puncture (spinal tap) and an MRI/fMRI scan before surgery
  • Have your brain activity recorded during surgery through a technique called EEG, which measures brain waves through a thin cap that you wear on your head

To learn more about the study, please watch this video:

What is it like to undergo a lumbar puncture (spinal tap) with the Duke Anesthesiology study team? Watch these two videos of Dr. Berger discussing the procedure with two past study participants:

Video 1:

Video 2:

Study Details

Full Title
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
Principal Investigator
Protocol Number
IRB: PRO00110914
Phase N/A
Enrollment Status
Open for Enrollment