Skin Cancers

Skin Cancers

Basal Cell and Squamous Cell Cancers

Call for an Appointment

Duke dermatologists perform comprehensive skin screenings to detect skin cancer -- including basal cell, squamous cell, and melanoma -- and use the most effective methods to treat skin cancer promptly. Our advanced training and seamless coordination with experts throughout Duke ensure you receive the best possible treatment, whether your skin cancer is contained to a small area or has advanced and requires specialized care. We do everything possible to cure your skin cancer and help you maintain cancer-free skin.

Our Doctors
Meet our doctors, view their profiles, and select the one that’s right for you.
sliders Refine Results
Use My Current Location Locations Near You
Find a Skin Cancers Doctor
Matching Results
Showing of Doctors
Load More View All

Melanoma and Non-Melanoma Skin Cancers

Knowing which type of cancer cell causes your skin cancer is important. Basal and squamous cancer cells, often referred to as non-melanoma skin cancers, are the most common form of skin cancer and usually result from too much sun exposure. While they need to be removed completely, they are treated differently than the more aggressive melanoma.

Our dermatologists detect and remove all skin cancers and work closely with cancer specialists when melanoma is diagnosed. Our goals are to provide the best care possible for your skin cancer and to achieve the best results.

Our Locations
Duke Health offers locations throughout the Triangle. Find one near you.

Treatments for Precancerous Lesions

Suspicious areas on the skin that may be related to sun damage (sometimes referred to as actinic keratosis) and very superficial cancer growths on the top layer of your skin may be treated with:


Liquid nitrogen spray freezes the suspicious area. A blister may form and fall off. New skin grows in its place.

Topical Chemotherapy Cream

Multiple applications of cream to the suspicious area destroy superficial cancer cells over time.

Photodynamic Therapy

A liquid drug is applied to the affected area and makes it sensitive to light. After an extended period of time, the area is targeted by a special light source, which removes the suspicious lesion.

Laser Surgery

A laser beam destroys the suspicious area and surrounding skin.

Treatments for Cancerous Lesions

Your doctor will develop a treatment plan for your skin cancer based on its location, how deeply it has penetrated the surface of your skin, and whether it has spread. Treatment options for basal and squamous cancers include:

Electrodessication and Curettage (ED&C)

A knifelike instrument, called a curette, is used to scrape away the layers of small cancerous lesions. An electric needle is then used to cauterize the wound. This stops the bleeding, seals the area, and destroys any remaining cancer cells.

Mohs Micrographic Surgery

Critical to the treatment of high-risk skin cancer, especially on the head and neck. Layers of basal cell or squamous cell cancers are surgically removed and examined under a microscope to ensure no cancerous cells remain. 

Targeted Therapy

When skin cancer spreads to other areas of the body or hasn’t responded to other treatments, a medication called vismodegib may be prescribed to block proteins in genes that tell cancer cells to grow. Vismodegib has been approved by the FDA   and is only prescribed by dermatologists, like ours, who have expertise with this medication.

Radiation Therapy

X-rays destroy cancer cells or shrink tumors. May be used in very select cases or to treat advanced basal-cell cancers.

Skin Grafting and Reconstructive Surgery

A skin graft from another part of your body is used to cover wounds after total removal of skin cancer. The grafting and reconstructive surgery promotes healing, restores the skin’s appearance and function, and minimizes the long-term impact of skin cancer surgery.

toy phone
Call for an Appointment


Our dermatologists use the latest technologies to identify pre-cancerous moles and detect all types of skin cancer. Screening and diagnostic tests include:

Physical Exam

Skin cancers are typically first identified during a physical exam, and the site may be examined more closely using a high-powered microscope called a dermatoscope.

Total Body Photography

If you have several moles on your body, or a family history of skin cancer, our dermatologists may use mole-mapping technology to take sequential photographs of your body from multiple angles. The photographs allow your dermatologist to track changes in your skin and evaluate your skin cancer risk over time.


If skin cancer is suspected, a sample of tissue will be removed and examined for the presence of cancer. The type of biopsy you undergo will be determined by how deep into your skin your physician believes the basal or squamous cells have penetrated. A shave biopsy takes less skin, while a punch biopsy removes a deeper portion of skin.

Duke University Hospital is nationally ranked in 10 adult specialties
Consistently Ranked Among the Nation’s Best Hospitals
In addition, Duke University Hospital is proud to be named the best hospital in North Carolina, and nationally ranked in 10 adult and 9 pediatric specialties by U.S. News & World Report for 2019–2020.

Experienced Skin Cancer Care

Expertise in Advanced Skin Cancers
While it’s rare for basal cell and squamous cell cancers to spread, it can happen. In addition, these cancers often grow locally and can damage structures on the face, including the nose and ears. Treating them effectively is crucial to ensuring the best possible outcome. We choose the best medical or surgical treatments for early and advanced skin cancers, to ensure you receive the most effective care for your condition.

A Team Approach to Care
In addition to dermatologists, your team may include medical, surgical, and radiation oncologists; otolaryngologists (ear, nose, and throat doctors); dermatopathologists (specialists who look at skin diseases at a cellular level); plastic surgeons; ophthalmologists; and radiologists, when their expertise is needed to develop the most effective treatment plan for you.

Expertise in Head and Neck Skin Cancer
Our experienced ear, nose, and throat surgeons are specially trained in removing skin cancers that involve the head and neck. Their expertise in working exclusively on the head and neck increases the likelihood that you will have positive outcomes for these complicated procedures.

Support for You and Your Family
Our comprehensive support services help you minimize the side effects of cancer treatment and help you and your family cope with the emotional and psychological effects of diagnosis and treatment. View all of our cancer support groups in our event calendar.  

Patient Resources