Bleeding and Clotting Disorders

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Duke’s hematology program diagnoses, evaluates, treats and manages all types of bleeding and clotting disorders including von Willebrand disease, hemophilia, deep vein thrombosis, and pulmonary embolism. We conduct research to better understand and treat these and other blood disorders, and partner with other Duke specialists to provide the most advanced, comprehensive care.

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Medication for Von Willebrand Disease

If you have low levels of von Willebrand factor, which allows blood to clot, medication may be prescribed to increase or replace this clotting factor or prevent the breakdown of blood clots. Women may need medications to control heavy menstrual bleeding.

Medication for Clotting Disorders

Blood thinners like heparin and warfarin decrease your blood’s ability to clot or prevent a blood clot from getting bigger. Medicines such as rivaroxaban and dabigatran have been approved for the treatment of various disorders associated with blood clots. You may be given medicines that interfere with the blood-clotting process or dissolve large blood clots. Doctors can also insert a filter into the large vein known as the vena cava to stop blood clots before they can travel to your lungs.   

Medication for Hemophilia

Replacement concentrates of clotting factor VIII may be given to people when levels are low, or missing in people with hemophilia A. Replacements of clotting factor IX may be given when low levels are found in those with hemophilia B. Other drugs stimulate the release of stored factor VIII in your blood or prevent clots from breaking down during replacement therapy.

Our Locations

Duke Health offers locations throughout the Triangle. Find one near you.


Blood Tests

Your doctor may order tests to:

  • Examine the various types of cells in your blood
  • Check clotting factors related to a bleeding or platelet disorder
  • Identify inherited blood clotting disorders that can cause deep vein thrombosis, a clot that forms in one of the body’s deep veins

Other blood-based tests are used to monitor treatment and to help you manage chronic blood-related conditions. Your blood may also be examined under a microscope to assess your platelets.

Bone Marrow Biopsy

A bone marrow sample is removed from your hipbone. This test may reveal characteristics that help your doctor determine the best course of treatment for you.

Imaging Tests

Ultrasound, which uses sound waves to create pictures of blood flowing through the arteries and veins in the leg, is used to check for deep vein thrombosis. Other imaging tests, such as CT or MRI scans, take pictures of your organs and tissues that may be affected by blood disorders.

D-Dimer Test

Measures a substance in blood that is produced when a blood clot dissolves. This can be helpful in detecting deep vein thrombosis.

Other Tests

Depending on your disorder, you may need additional tests on an ongoing basis. If you have a blood clotting disorder, you may need regular blood tests to monitor your medication. 

New Patient Appointment

Comprehensive Care for Bleeding and Clotting Disorders

Access to Clinical Trials
Our doctors are involved in numerous clinical trials aimed at improving treatments for people with blood and clotting disorders. You may have the opportunity to participate in our ongoing clinical trials to test new therapies and surgical approaches before they become widely available at other centers.

Treatment of Rare Clotting Disorders
Our specialists see patients with unusual and uncommon disorders. We coordinate your care with other specialists throughout Duke.

A Team of Specialists
Our team approach and emphasis on preventing complications will help provide you with the best care.

Expertise in Blood Conditions Unique to Women
Duke’s Women’s Hemostasis and Thrombosis Clinic coordinates the special care required by women with bleeding and clotting disorders. We have the expertise and experience to help you manage the increased risks associated with pregnancy and childbirth.

Consistently Ranked Among the Nation’s Best Hospitals

Duke University Hospital is proud of our team and the exceptional care they provide. They are why we are once again recognized as the best hospital in North Carolina, and nationally ranked in 11 adult and 9 pediatric specialties by U.S. News & World Report for 2023–2024.