Open for Enrollment Soon
This study will open for enrollment soon. Please contact the study team for more information and check back frequently.

ETS3: Study of Eyeglasses for Esotropia ("Crossed Eyes") - Clinical Trial

What is the Purpose of this Study?

Most children with esotropia need to wear glasses. Some doctors prescribe single-vision glasses (regular glasses), and some doctors prescribe bifocal glasses. However, we still do not have enough information to know which of these two types of glasses work better (or worse). We hope this study can help us figure out if one option is better than the other, or to help us understand which of the choices might be better for different kids.

What is the Condition Being Studied?

Esotropia ("Crossed Eyes")

Who Can Participate in the Study?

Children ages 3-9 who:

- Are diagnosed with esotropia

- Do not wear contacts

- Are not currently being treated for amblyopia

For more information about who can join this study, please contact the study team at

Age Group

What is Involved?

If your child chooses to join this study, they will:

- Get a random assignment (like a coin flip) to wear either bifocal glasses or regular glasses

- Visit our clinic 10 times over the course of about 3 years

There will be vision and eye tests during the study visits.

Study Details

Full Title
Randomized Trial of Bifocal Spectacles vs. Single Vision Spectacles for Esotropia Greater at Near - ETS3
Principal Investigator
Pediatric Optometrist
Protocol Number
IRB: PRO00114228
NCT: NCT05527015
Phase III
Enrollment Status
Open for Enrollment Soon