COMPASS HER2+ Breast with Residual Disease (A011801) - Clinical Trial
What is the Purpose of this Study?
We are doing this study to find out if adding a drug called tucatinib to the usual treatment of T-DM1 on its own can help prevent breast cancer from returning.
Breast Cancer
Who Can Participate in the Study?
Adults 18+ who:
- Are diagnosed with HER2+ breast cancer
- Have been previously treated with one of the following chemotherapy regimens: THP, TMP, AC-TH(P); TCH(P); FAC-TH(P), or FEC-TH(P)
For more information about who can join this study, please contact the study team at nick.jeffries@duke.edu.
What is Involved?
If you choose to join this study, you will be randomly assigned (like a coin flip) to 1 of 2 groups:
- One group will get T-DMI and placebo ("sugar pills" that contain no medicine)
- The other group will get T-DMI and tucatinib (the study regimen)
T-DMI is given as an infusion through a vein (IV) in the arm once every 3 weeks. Tucatinib and the placebo are pills that you will take by mouth twice each day while you are in the study.
Participation in this study, whether you are assigned to get the study regimen or the usual treatment, will last for up to 42 weeks.
Study Details
