Lyell LYL845 (Solid Tumors) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if an experimental drug called LYL845 (the study drug) is a safe and effective treatment for your cancer. The study drug is custom-made for each participant from their own tumor tissue.

What is the Condition Being Studied?

Melanoma, Non-Small Cell Lung Cancer (NSCLC), or Colorectal Cancer

Who Can Participate in the Study?

Adults ages 18-75 who:

- Are diagnosed with melanoma, NSCLC or colorectal cancer

- Have received at least one round of previous treatment

- Have tumor tissue that can be surgically removed

- Have never received treatment with a cellular therapy

For more information about who can join this study, please contact the study team at 919-681-6468

Age Group

What is Involved?

If you choose to join this study, you will:

- Undergo surgery to collect your tumor tissue to make the study drug

- Receive lympho-depleting chemotherapy

- Take the study drug

- Have physical exams and blood draws

- Have imaging scans (CT and/or MRI)

- Have heart tests (ECG)

Study Details

Full Title
A Phase 1 Study to Assess the Safety and Efficacy of LYL845 in Adults with Relapsed and/or Refractory Metastatic or Locally Advanced Melanoma and Selected Solid Tumor Malignancies
Principal Investigator
Medical Oncologist
Protocol Number
IRB: PRO00112139
NCT: NCT05573035
Phase I
Enrollment Status
Open for Enrollment