DEPTH Trial (Emphysema in People Living with HIV) - Clinical Trial

What is the Purpose of this Study?


If you choose to join this study, you will complete up to 10 study visits and 2 phone call check-ins over 72 weeks. This study includes:
- Pulmonary function tests (how well your lungs are working)
- CT scans of the chest (a special type of imaging that creates 3D X-ray images)
- Blood draws
- Questionnaires

During the study, you will be randomized (like flipping a coin) to get either:
- The study drug (Doxycycline) by mouth twice a day for 72 weeks; OR
- A placebo (sugar pill) by mouth twice a day for 72 weeks

What is the Condition Being Studied?

Emphysema in People Living with HIV

Who Can Participate in the Study?

Key Eligibility

Adults ages 30+ who:
- Are living with HIV
- Have smoking-related lung disease

For more information about who can join this study, please contact the study team at or 919-684-2285.

Age Group

What is Involved?


We are doing this study to learn more about whether Doxycycline (an antibiotic medication) will help slow the progression of emphysema, or COPD.

Study Details

Full Title
Doxycycline for Emphysema in People Living with HIV (The DEPTH Trial)
Principal Investigator
Protocol Number
IRB: PRO00111021
NCT: NCT05382208
Phase II
Enrollment Status
Open for Enrollment