Inspiratory Muscle Training in LOPD (Pompe Disease) - Clinical Trial

What is the Purpose of this Study?

We are doing this study to find out if an inspiratory muscle training (IMT) program is beneficial for people with LOPD. We want to know if IMT can help reduce the effects of weakness in breathing muscles and improve the quality of life for people with LOPD.

What is the Condition Being Studied?

Late-Onset Pompe Disease (LOPD)

Who Can Participate in the Study?

Adults ages 18+ who:

- Are diagnosed with LOPD

- Have access to a computer or tablet, a smartphone, and a reliable internet connection

For more information about this study, please contact the study team at

Age Group

What is Involved?

If you choose to join this study, you will:

- Use a device called PrO2 to complete your IMT program

- Do exercises according to your IMT program 3 times per week

The study's IMT program lasts for about 6 months. The PrO2 device you use in this study will share your training results with our staff. We might use this information to make changes to your exercise program while you are in the study.

Study Details

Full Title
High-dose inspiratory muscle training (IMT) in late-onset Pompe disease (LOPD)
Principal Investigator
Protocol Number
IRB: PRO00109392
NCT: NCT05431127
Phase N/A
Enrollment Status
Open for Enrollment