Sharon F. Freedman, MD
Chief, Pediatric Ophthalmology and Strabismus Service
Departments / Divisions- Ophthalmology / Pediatric Ophthalmology
- Pediatrics / Pediatrics-Chairman Office
Address
DUMC 3802
Durham, NC 27710
Appointment Telephone
919-681-3937
Fax Telephone
919-684-6096
- MD, Harvard Medical School (Massachusetts), 1985
- Ophthalmology, Massachusetts Eye and Ear Infirmary, 1986-1989
- Pediatric Ophthalmology, Children's Hospital Boston (Massachusetts), 1989-1990
- Glaucoma, Duke Eye Center, 1990-1992
Clinical Interests
Congenital and childhood glaucoma, strabismus, congenital cataracts,
retinopathy of prematurity, ocular motility disorders due to cranial nerve
palsies
Research Interests
My current research interests include:
Childhood glaucomas - With a large referral practice of children with pediatric glaucomas of all types, Freedman is evaluating existing and new management strategies for treating refractory congenital and childhood glaucomas, including the use of pharmacologic agents, as well as modification of surgical interventions. Freedman has an on-going collaboration with Duke colleagues to study the genetics of pediatric glaucoma. In addition to an active clinical research program, she regularly lectures and directs workshop at national meetings aimed at educating other ophthalmologists about current strategies and controversies in managing children with refractory glaucoma.
Retinopathy of Prematurity - Freedman was the principal investigator at the Duke-UNC Center for the NIH-sponsored, multi-center trial to evaluate early treatment for retinopathy of prematurity (ETROP). Together with colleague David Wallace, she provides eye care and treatment to the many premature children who graduate from the Neonatal Intensive Care units at DUHS. Freedman and Wallace are involved in clinical research involving the computerized evaluation of retinal blood vessels in ROP. Freedman and Wallace collaborate with Cynthia Toth and her Duke research team in applying the new imaging technique of Spectral Domain Optical Coherence Tomography to image children with retinopathy of prematurity and other retinal disorders. Efforts are ongoing to investigate the role of the anti-vascular endothelial growth factor drug, bevasizumab in treating severe ROP.
Strabismus associated with macular translocation surgery - Together with Cynthia Toth, Freedman continues to surgically treat the cyclotorsion and strabismus resulting from macular translocation surgery (now reserved for special cases of macular degeneration that are resistent to injection therapy. She has developed and published on new extraocular muscle surgical techniques to deal with this problem.
This faculty member has no reported relationships with industry.
Representative Publications
Beck, AD; Freedman, SF; Lynn, MJ; Bothun, E; Neely, DE; Lambert, SR; Infant Aphakia Treatment Study Group. Glaucoma-related adverse events in the Infant Aphakia Treatment Study: 1-year results. Archives of Ophthalmology. 2012;130:300-305.
(2012)
Abstract
Cabrera, MT; Maldonado, RS; Toth, CA; O'Connell, RV; Chen, BB; Chiu, SJ; Farsiu, S; Wallace, DK; Stinnett, SS; Panayotti, GM; Swamy, GK; Freedman, SF. Subfoveal fluid in healthy full-term newborns observed by handheld spectral-domain optical coherence tomography. American Journal of Ophthalmology. 2012;153:167-75.e3.
(2012)
Abstract
Maldonado, RS; O'Connell, R; Ascher, SB; Sarin, N; Freedman, SF; Wallace, DK; Chiu, SJ; Farsiu, S; Cotten, M; Toth, CA. Spectral-domain optical coherence tomographic assessment of severity of cystoid macular edema in retinopathy of prematurity. Archives of Ophthalmology. 2012;130:569-578.
(2012)
Abstract
Cabrera, MT; Freedman, SF; Kiely, AE; Chiang, MF; Wallace, DK. Combining ROPtool measurements of vascular tortuosity and width to quantify plus disease in retinopathy of prematurity. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2011;15:40-44.
(2011)
Abstract
El-Dairi, M; Holgado, S; Asrani, S; Freedman, SF. Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios. Experimental Eye Research. 2011;93:299-307.
(2011)
Abstract
Estrada, R; Tomasi, C; Cabrera, MT; Wallace, DK; Freedman, SF; Farsiu, S. Enhanced video indirect ophthalmoscopy (VIO) via robust mosaicing. Biomedical Optics Express. 2011;2:2871-2887.
(2011)
Abstract
Flemmons, MS; Hsiao, YC; Dzau, J; Asrani, S; Jones, S; Freedman, SF. Home tonometry for management of pediatric glaucoma. American Journal of Ophthalmology. 2011;152:470-478.e2.
(2011)
Abstract
Flemmons, MS; Hsiao, YC; Dzau, J; Asrani, S; Jones, S; Freedman, SF. Icare rebound tonometry in children with known and suspected glaucoma. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2011;15:153-157.
(2011)
Abstract
Gupta, PK; Asrani, S; Freedman, SF; El-Dairi, M; Bhatti, MT. Differentiating glaucomatous from non-glaucomatous optic nerve cupping by optical coherence tomography. Open Neurology Journal. 2011;5:1-7.
(2011)
Abstract
Lee, AC; Maldonado, RS; Sarin, N; O'Connell, RV; Wallace, DK; Freedman, SF; Cotten, M; Toth, CA. Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurity. Retina: the Journal of Retinal and Vitreous Diseases. 2011;31:1470-1482.
(2011)
Abstract
Lim, Z; Muir, KW; Duncan, L; Freedman, SF. Acquired central corneal thickness increase following removal of childhood cataracts. American Journal of Ophthalmology. 2011;151:434-41.e1.
(2011)
Abstract
Maeda-Chubachi, T; Chi-Burris, K; Simons, BD; Freedman, SF; Khaw, PT; Wirostko, B; Yan, E; A6111137 Study Group. Comparison of latanoprost and timolol in pediatric glaucoma: a phase 3, 12-week, randomized, double-masked multicenter study. Ophthalmology. 2011;118:2014-2021.
(2011)
Abstract
Maldonado, RS; O'Connell, RV; Sarin, N; Freedman, SF; Wallace, DK; Cotten, CM; Winter, KP; Stinnett, S; Chiu, SJ; Izatt, JA; Farsiu, S; Toth, CA. Dynamics of human foveal development after premature birth. Ophthalmology. 2011;118:2315-2325.
(2011)
Abstract
Raber, S; Courtney, R; Maeda-Chubachi, T; Simons, BD; Freedman, SF; Wirostko, B; A6111139 Study Group. Latanoprost systemic exposure in pediatric and adult patients with glaucoma: a phase 1, open-label study. Ophthalmology. 2011;118:2022-2027.
(2011)
Abstract
Wallace, DK; Freedman, SF; Hartnett, ME; Quinn, GE. Predictive value of pre-plus disease in retinopathy of prematurity. Archives of Ophthalmology. 2011;129:591-596.
(2011)
Abstract
Kiely, AE; Wallace, DK; Freedman, SF; Zhao, Z. Computer-assisted measurement of retinal vascular width and tortuosity in retinopathy of prematurity. Archives of Ophthalmology. 2010;128:847-852.
(2010)
Abstract
Yanovitch, T; Wallace, DK; Freedman, SF; Enyedi, LB; Kishnani, P; Worley, G; Crissman, B; Burner, E; Young, TL. The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2010;14:472-477.
(2010)
Abstract
Black, AC; Jones, S; Yanovitch, TL; Enyedi, LB; Stinnett, SS; Freedman, SF. Latanoprost in pediatric glaucoma--pediatric exposure over a decade. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2009;13:558-562.
(2009)
Abstract
Chavala, SH; Farsiu, S; Maldonado, R; Wallace, DK; Freedman, SF; Toth, CA. Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging. Ophthalmology. 2009;116:2448-2456.
(2009)
Abstract
Chong, GT; Farsiu, S; Freedman, SF; Sarin, N; Koreishi, AF; Izatt, JA; Toth, CA. Abnormal foveal morphology in ocular albinism imaged with spectral-domain optical coherence tomography. Archives of Ophthalmology. 2009;127:37-44.
(2009)
Abstract
El-Dairi, MA; Asrani, SG; Enyedi, LB; Freedman, SF. Optical coherence tomography in the eyes of normal children. Archives of Ophthalmology. 2009;127:50-58.
(2009)
Abstract
El-Dairi, MA; Holgado, S; Asrani, SG; Enyedi, LB; Freedman, SF. Correlation between optical coherence tomography and glaucomatous optic nerve head damage in children. British Journal of Ophthalmology. 2009;93:1325-1330.
(2009)
Abstract
Johnston, SC; Wallace, DK; Freedman, SF; Yanovitch, TL; Zhao, Z. Tortuosity of arterioles and venules in quantifying plus disease. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2009;13:181-185.
(2009)
Abstract
Wallace, DK; Freedman, SF; Zhao, Z. Evolution of plus disease in retinopathy of prematurity: quantification by ROPtool. Transactions of the American Ophthalmological Society. 2009;107:47-52.
(2009)
Abstract
Wright, TM; Freedman, SF. Exposure to topical apraclonidine in children with glaucoma. Journal of Glaucoma. 2009;18:395-398.
(2009)
Abstract
Yanovitch, TL; Enyedi, LB; Schotthoeffer, EO; Freedman, SF. Travoprost in children: adverse effects and intraocular pressure response. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2009;13:91-93.
(2009)
Abstract
Yanovitch, TL; Freedman, SF; Wallace, DK. Vascular dilation and tortuosity in plus disease. Archives of Ophthalmology. 2009;127:112-113.
(2009)
Abstract
Ahmad, S; Wallace, DK; Freedman, SF; Zhao, Z. Computer-assisted assessment of plus disease in retinopathy of prematurity using video indirect ophthalmoscopy images. Retina: the Journal of Retinal and Vitreous Diseases. 2008;28:1458-1462.
(2008)
Abstract
Freedman, SF. Central corneal thickness in children--does it help or hinder our evaluation of eyes at risk for glaucoma?. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2008;12:1-2.
(2008)
Abstract
Kemper, AR; Freedman, SF; Wallace, DK. Retinopathy of prematurity care: patterns of care and workforce analysis. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2008;12:344-348.
(2008)
Abstract
O'Malley Schotthoefer, E; Yanovitch, TL; Freedman, SF. Aqueous drainage device surgery in refractory pediatric glaucoma: II. Ocular motility consequences. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2008;12:40-45.
(2008)
Abstract
O'Malley Schotthoefer, E; Yanovitch, TL; Freedman, SF. Aqueous drainage device surgery in refractory pediatric glaucomas: I. Long-term outcomes. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2008;12:33-39.
(2008)
Abstract
Wallace, DK; Quinn, GE; Freedman, SF; Chiang, MF. Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2008;12:352-356.
(2008)
Abstract
Al-Haddad, CE; Freedman, SF. Endoscopic laser cyclophotocoagulation in pediatric glaucoma with corneal opacities. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2007;11:23-28.
(2007)
Abstract
El-Dairi, MA; Holgado, S; O'Donnell, T; Buckley, EG; Asrani, S; Freedman, SF. Optical coherence tomography as a tool for monitoring pediatric pseudotumor cerebri. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2007;11:564-570.
(2007)
Abstract
Holgado, S; Toth, CA; Freedman, SF. Fixation switch and diplopia after full macular translocation surgery. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2007;11:114-119.
(2007)
Abstract
Muir, KW; Duncan, L; Enyedi, LB; Wallace, DK; Freedman, SF. Central corneal thickness: congenital cataracts and aphakia. American Journal of Ophthalmology. 2007;144:502-506.
(2007)
Abstract
Wallace, DK; Freedman, SF; Zhao, Z; Jung, SH. Accuracy of ROPtool vs individual examiners in assessing retinal vascular tortuosity. Archives of Ophthalmology. 2007;125:1523-1530.
(2007)
Abstract
Wallace, DK; Zhao, Z; Freedman, SF. A pilot study using "ROPtool" to quantify plus disease in retinopathy of prematurity. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2007;11:381-387.
(2007)
Abstract
Holgado, S; Enyedi, LB; Toth, CA; Freedman, SF. Extraocular muscle surgery for extorsion after macular translocation surgery new surgical technique and clinical management. Ophthalmology. 2006;113:63-69.
(2006)
Abstract
Muir, KW; Duncan, L; Enyedi, LB; Freedman, SF. Central corneal thickness in children: Racial differences (black vs. white) and correlation with measured intraocular pressure. Journal of Glaucoma. 2006;15:520-523.
(2006)
Abstract
Muir, KW; Duncan, L; Enyedi, LB; Stinnett, SS; Freedman, SF. Central corneal thickness in children: stability over time. American Journal of Ophthalmology. 2006;141:955-957.
(2006)
Abstract
Trigler, L; Proia, AD; Freedman, SF. Fibrovascular ingrowth as a cause of Ahmed glaucoma valve failure in children. American Journal of Ophthalmology. 2006;141:388-389.
(2006)
Abstract
Cahill, MT; Stinnett, SS; Banks, AD; Freedman, SF; Toth, CA. Quality of life after macular translocation with 360 degrees peripheral retinectomy for age-related macular degeneration. Ophthalmology. 2005;112:144-151.
(2005)
Abstract
Hess, DB; Asrani, SG; Bhide, MG; Enyedi, LB; Stinnett, SS; Freedman, SF. Macular and retinal nerve fiber layer analysis of normal and glaucomatous eyes in children using optical coherence tomography. American Journal of Ophthalmology. 2005;139:509-517.
(2005)
Abstract
Tesser, R; Hess, DB; Freedman, SF. Combined intraocular lens implantation and glaucoma implant (tube shunt) surgery in pediatric patients: a case series. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2005;9:330-335.
(2005)
Abstract
Trigler, L; Weaver, RG; O'Neil, JW; Barondes, MJ; Freedman, SF. Case series of angle-closure glaucoma after laser treatment for retinopathy of prematurity. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2005;9:17-21.
(2005)
Abstract
Muir, KW; Jin, J; Freedman, SF. Central corneal thickness and its relationship to intraocular pressure in children. Ophthalmology. 2004;111:2220-2223.
(2004)
Abstract
Cahill, MT; Freedman, SF; Toth, CA. Macular translocation with 360 degrees peripheral retinectomy for geographic atrophy. Archives of Ophthalmology. 2003;121:132-133.
(2003)
Abstract
Dawn, AG; Freedman, SF; Lee, PP; Enyedi, LB. Parents' expectations regarding their children's eye care: interview results. American Journal of Ophthalmology. 2003;136:797-804.
(2003)
Abstract
Freedman, SF; Gearinger, MD; Enyedi, LB; Holgado, S; Toth, CA. Measurement of ocular torsion after macular translocation: disc fovea angle and Maddox rod. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2003;7:103-107.
(2003)
Abstract
Freedman, SF; Holgado, S; Enyedi, LB; Toth, CA. Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study. American Journal of Ophthalmology. 2003;136:640-648.
(2003)
Abstract
Enyedi, LB; Freedman, SF. Latanoprost for the treatment of pediatric glaucoma. Survey of Ophthalmology. 2002;47 Suppl 1:S129-S132.
(2002)
Abstract
Freedman, SF; Rodriguez-Rosa, RE; Rojas, MC; Enyedi, LB. Goniotomy for glaucoma secondary to chronic childhood uveitis. American Journal of Ophthalmology. 2002;133:617-621.
(2002)
Abstract
Freedman, SF; Rojas, M; Toth, CA. Strabismus surgery for large-angle cyclotorsion after macular translocation surgery. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2002;6:154-162.
(2002)
Abstract
Beck, AD; Freedman, SF. Trabeculectomy with mitomycin-C in pediatric glaucomas. Ophthalmology. 2001;108:835-837.
(2001)
Abstract
Enyedi, LB; Freedman, SF. Safety and efficacy of brimonidine in children with glaucoma. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2001;5:281-284.
(2001)
Abstract
Toth, CA; Freedman, SF. Macular translocation with 360-degree peripheral retinectomy impact of technique and surgical experience on visual outcomes. Retina: the Journal of Retinal and Vitreous Diseases. 2001;21:293-303.
(2001)
Abstract
Freedman, SF; Seaber, JH; Buckley, EG; Enyedi, LB; Toth, CA. Combined superior oblique muscle recession and inferior oblique muscle advancement and transposition for cyclotorsion associated with macular translocation surgery. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2000;4:75-83.
(2000)
Abstract
Bock, CJ; Buckley, EG; Freedman, SF. Combined resection and recession of a single rectus muscle for the treatment of incomitant strabismus. Journal of American Association for Pediatric Ophthalmology and Strabismus. 1999;3:263-268.
(1999)
Abstract
Englert, JA; Freedman, SF; Cox, TA. The Ahmed valve in refractory pediatric glaucoma. American Journal of Ophthalmology. 1999;127:34-42.
(1999)
Abstract
Enyedi, LB; Freedman, SF; Buckley, EG. The effectiveness of latanoprost for the treatment of pediatric glaucoma. Journal of American Association for Pediatric Ophthalmology and Strabismus. 1999;3:33-39.
(1999)
Abstract
Freedman, SF; McCormick, K; Cox, TA. Mitomycin C-augumented trabeculectomy with postoperative wound modulation in pediatric glaucoma. Journal of American Association for Pediatric Ophthalmology and Strabismus. 1999;3:117-124.
(1999)
Abstract
Enyedi, LB; Peterseim, MW; Freedman, SF; Buckley, EG. Refractive changes after pediatric intraocular lens implantation. American Journal of Ophthalmology. 1998;126:772-781.
(1998)
Abstract
Portellos, M; Buckley, EG; Freedman, SF. Topical versus oral carbonic anhydrase inhibitor therapy for pediatric glaucoma. Journal of American Association for Pediatric Ophthalmology and Strabismus. 1998;2:43-47.
(1998)
Abstract
Wagle, NS; Freedman, SF; Buckley, EG; Davis, JS; Biglan, AW. Long-term outcome of cyclocryotherapy for refractory pediatric glaucoma. Ophthalmology. 1998;105:1921-1926.
(1998)
Abstract
Wallace, DK; Kylstra, JA; Greenman, DB; Freedman, SF. Significance of isolated neovascular tufts ("popcorn") in retinopathy of prematurity. Journal of American Association for Pediatric Ophthalmology and Strabismus. 1998;2:52-56.
(1998)
Abstract
Bock, CJ; Freedman, SF; Buckley, EG; Shields, MB. Transscleral diode laser cyclophotocoagulation for refractory pediatric glaucomas. Journal of Pediatric Ophthalmology and Strabismus. 1997;34:235-239.
(1997)
Abstract
Freedman, SF; Kylstra, JA; Capowski, JJ; Realini, TD; Rich, C; Hunt, D. Observer sensitivity to retinal vessel diameter and tortuosity in retinopathy of prematurity: a model system. Journal of Pediatric Ophthalmology and Strabismus. 1996;33:248-254.
(1996)
Abstract
Capowski, JJ; Kylstra, JA; Freedman, SF. A numeric index based on spatial frequency for the tortuosity of retinal vessels and its application to plus disease in retinopathy of prematurity. Retina: the Journal of Retinal and Vitreous Diseases. 1995;15:490-500.
(1995)
Abstract
Hall, JG; Freedman, SF; Kylstra, JA. Clinical course and systemic correlates of retinopathy of prematurity in quintuplets. American Journal of Ophthalmology. 1995;119:658-660.
(1995)
Abstract
Freedman, SF; Freedman, NJ; Shields, MB; Lobaugh, B; Samsa, GP; Keates, EU; Ollie, A. Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. American Journal of Ophthalmology. 1993;116:600-611.
(1993)
Abstract
