Sharon F. Freedman, MD
Chief, Pediatric Ophthalmology and Strabismus Service
Departments / Divisions- Ophthalmology / Pediatric Ophthalmology
- Pediatrics / Pediatrics-Chairman Office
Address
DUMC 3802
Durham, NC 27710
Appointment Telephone
919-681-3937
Fax Telephone
919-684-6096
- MD, Harvard Medical School (Massachusetts), 1985
- Ophthalmology, Massachusetts Eye and Ear Infirmary, 1986-1989
- Pediatric Ophthalmology, Children's Hospital Boston (Massachusetts), 1989-1990
- Glaucoma, Duke Eye Center, 1990-1992
Clinical Interests
Congenital and childhood glaucoma, strabismus, congenital cataracts,
retinopathy of prematurity, ocular motility disorders due to cranial nerve
palsies
Research Interests
My current research interests include:
Childhood glaucomas - With a large referral practice of children with pediatric glaucomas of all types, Freedman is evaluating existing and new management strategies for treating refractory congenital and childhood glaucomas, including the use of pharmacologic agents, as well as modification of surgical interventions. Freedman has an on-going collaboration with Duke colleagues to study the genetics of pediatric glaucoma. In addition to an active clinical research program, she regularly lectures and directs workshop at national meetings aimed at educating other ophthalmologists about current strategies and controversies in managing children with refractory glaucoma.
Retinopathy of Prematurity - Freedman was the principal investigator at the Duke-UNC Center for the NIH-sponsored, multi-center trial to evaluate early treatment for retinopathy of prematurity (ETROP). Together with colleague David Wallace, she provides eye care and treatment to the many premature children who graduate from the Neonatal Intensive Care units at DUHS. Freedman and Wallace are involved in clinical research involving the computerized evaluation of retinal blood vessels in ROP. Freedman and Wallace collaborate with Cynthia Toth and her Duke research team in applying the new imaging technique of Spectral Domain Optical Coherence Tomography to image children with retinopathy of prematurity and other retinal disorders. Efforts are ongoing to investigate the role of the anti-vascular endothelial growth factor drug, bevasizumab in treating severe ROP.
Strabismus associated with macular translocation surgery - Together with Cynthia Toth, Freedman continues to surgically treat the cyclotorsion and strabismus resulting from macular translocation surgery (now reserved for special cases of macular degeneration that are resistent to injection therapy. She has developed and published on new extraocular muscle surgical techniques to deal with this problem.
This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Pfizer Inc.
Representative Publications
Cabrera MT, Maldonado RS, Toth CA, O'Connell RV, Chen BB, Chiu SJ, Farsiu S, Wallace DK, Stinnett SS, Maradiaga Panayotti GM, Swamy GK, Freedman SF. Subfoveal Fluid in Healthy Full-term Newborns Observed by Handheld Spectral-Domain Optical Coherence Tomography. Am J Ophthalmol. 2012 Jan;153(1):167-175.e3.
(2012)
Abstract
Maldonado RS, O'Connell R, Ascher SB, Sarin N, Freedman SF, Wallace DK, Chiu SJ, Farsiu S, Cotten M, Toth CA. Spectral-Domain Optical Coherence Tomographic Assessment of Severity of Cystoid Macular Edema in Retinopathy of Prematurity. Arch Ophthalmol. 2012 Jan 9.
(2012)
Abstract
Beck AD, Freedman SF, Lynn MJ, Bothun E, Neely DE, Lambert SR, . Glaucoma-Related Adverse Events in the Infant Aphakia Treatment Study: 1-Year Results. Arch Ophthalmol. 2011 Nov 14.
(2011)
Abstract
Cabrera MT, Freedman SF, Kiely AE, Chiang MF, Wallace DK. Combining ROPtool measurements of vascular tortuosity and width to quantify plus disease in retinopathy of prematurity. J AAPOS. 2011 Feb;15(1):40-4.
(2011)
Abstract
El-Dairi M, Holgado S, Asrani S, Freedman SF. Optical coherence tomography (OCT) measurements in black and white children with large cup-to-disc ratios. Exp Eye Res. 2011 Sep;93(3):299-307.
(2011)
Abstract
Estrada R, Tomasi C, Cabrera MT, Wallace DK, Freedman SF, Farsiu S. Enhanced video indirect ophthalmoscopy (VIO) via robust mosaicing. Biomed Opt Express. 2011 Oct 1;2(10):2871-87.
(2011)
Abstract
Flemmons MS, Hsiao YC, Dzau J, Asrani S, Jones S, Freedman SF. Home tonometry for management of pediatric glaucoma. Am J Ophthalmol. 2011 Sep;152(3):470-478.e2.
(2011)
Abstract
Flemmons MS, Hsiao YC, Dzau J, Asrani S, Jones S, Freedman SF. Icare rebound tonometry in children with known and suspected glaucoma. J AAPOS. 2011 Mar 16.
(2011)
Abstract
Gupta PK, Asrani S, Freedman SF, El-Dairi M, Bhatti MT. Differentiating glaucomatous from non-glaucomatous optic nerve cupping by optical coherence tomography. Open Neurol J. 2011;5:1-7.
(2011)
Abstract
Lee AC, Maldonado RS, Sarin N, O'Connell RV, Wallace DK, Freedman SF, Cotten M, Toth CA. Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurity. Retina. 2011 Sep;31(8):1470-82.
(2011)
Abstract
Lim Z, Muir KW, Duncan L, Freedman SF. Acquired central corneal thickness increase following removal of childhood cataracts. Am J Ophthalmol. 2011 Mar;151(3):434-41.e1.
(2011)
Abstract
Maeda-Chubachi T, Chi-Burris K, Simons BD, Freedman SF, Khaw PT, Wirostko B, Yan E, . Comparison of latanoprost and timolol in pediatric glaucoma: a phase 3, 12-week, randomized, double-masked multicenter study. Ophthalmology. 2011 Oct;118(10):2014-21.
(2011)
Abstract
Maldonado RS, O'Connell RV, Sarin N, Freedman SF, Wallace DK, Cotten CM, Winter KP, Stinnett S, Chiu SJ, Izatt JA, Farsiu S, Toth CA. Dynamics of human foveal development after premature birth. Ophthalmology. 2011 Dec;118(12):2315-25.
(2011)
Abstract
Raber S, Courtney R, Maeda-Chubachi T, Simons BD, Freedman SF, Wirostko B, . Latanoprost systemic exposure in pediatric and adult patients with glaucoma: a phase 1, open-label study. Ophthalmology. 2011 Oct;118(10):2022-7.
(2011)
Abstract
Wallace DK, Freedman SF, Hartnett ME, Quinn GE. Predictive value of pre-plus disease in retinopathy of prematurity. Arch Ophthalmol. 2011 May;129(5):591-6.
(2011)
Abstract
Kiely AE, Wallace DK, Freedman SF, Zhao Z. Computer-assisted measurement of retinal vascular width and tortuosity in retinopathy of prematurity. Arch Ophthalmol. 2010 Jul;128(7):847-52.
(2010)
Abstract
Yanovitch T, Wallace DK, Freedman SF, Enyedi LB, Kishnani P, Worley G, Crissman B, Burner E, Young TL. The accuracy of photoscreening at detecting treatable ocular conditions in children with Down syndrome. J AAPOS. 2010 Dec;14(6):472-7.
(2010)
Abstract
Black AC, Jones S, Yanovitch TL, Enyedi LB, Stinnett SS, Freedman SF. Latanoprost in pediatric glaucoma--pediatric exposure over a decade. J AAPOS. 2009 Dec;13(6):558-62.
(2009)
Abstract
Chavala SH, Farsiu S, Maldonado R, Wallace DK, Freedman SF, Toth CA. Insights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging. Ophthalmology. 2009 Dec;116(12):2448-56.
(2009)
Abstract
Chong GT, Farsiu S, Freedman SF, Sarin N, Koreishi AF, Izatt JA, Toth CA. Abnormal foveal morphology in ocular albinism imaged with spectral-domain optical coherence tomography. Arch Ophthalmol. 2009 Jan;127(1):37-44.
(2009)
Abstract
El-Dairi MA, Asrani SG, Enyedi LB, Freedman SF. Optical coherence tomography in the eyes of normal children. Arch Ophthalmol. 2009 Jan;127(1):50-8.
(2009)
Abstract
El-Dairi MA, Holgado S, Asrani SG, Enyedi LB, Freedman SF. Correlation between optical coherence tomography and glaucomatous optic nerve head damage in children. Br J Ophthalmol. 2009 Oct;93(10):1325-30.
(2009)
Abstract
Johnston SC, Wallace DK, Freedman SF, Yanovitch TL, Zhao Z. Tortuosity of arterioles and venules in quantifying plus disease. J AAPOS. 2009 Apr;13(2):181-5.
(2009)
Abstract
Wallace DK, Freedman SF, Zhao Z. Evolution of plus disease in retinopathy of prematurity: quantification by ROPtool. Trans Am Ophthalmol Soc. 2009 Dec;107:47-52.
(2009)
Abstract
Wright TM, Freedman SF. Exposure to topical apraclonidine in children with glaucoma. J Glaucoma. 2009 Jun-Jul;18(5):395-8.
(2009)
Abstract
Yanovitch TL, Enyedi LB, Schotthoeffer EO, Freedman SF. Travoprost in children: adverse effects and intraocular pressure response. J AAPOS. 2009 Feb;13(1):91-3.
(2009)
Abstract
Yanovitch TL, Freedman SF, Wallace DK. Vascular dilation and tortuosity in plus disease. Arch Ophthalmol. 2009 Jan;127(1):112-3.
(2009)
Abstract
Ahmad S, Wallace DK, Freedman SF, Zhao Z. Computer-assisted assessment of plus disease in retinopathy of prematurity using video indirect ophthalmoscopy images. Retina. 2008 Nov-Dec;28(10):1458-62.
(2008)
Abstract
Freedman SF. Central corneal thickness in children--does it help or hinder our evaluation of eyes at risk for glaucoma? J AAPOS. 2008 Feb;12(1):1-2.
(2008)
Abstract
Kemper AR, Freedman SF, Wallace DK. Retinopathy of prematurity care: patterns of care and workforce analysis. J AAPOS. 2008 Aug;12(4):344-8.
(2008)
Abstract
Wallace DK, Quinn GE, Freedman SF, Chiang MF. Agreement among pediatric ophthalmologists in diagnosing plus and pre-plus disease in retinopathy of prematurity. J AAPOS. 2008 Aug;12(4):352-6.
(2008)
Abstract
Al-Haddad CE, Freedman SF. Endoscopic laser cyclophotocoagulation in pediatric glaucoma with corneal opacities. J AAPOS. 2007 Feb;11(1):23-8.
(2007)
Abstract
El-Dairi MA, Holgado S, O'Donnell T, Buckley EG, Asrani S, Freedman SF. Optical coherence tomography as a tool for monitoring pediatric pseudotumor cerebri. J AAPOS. 2007 Dec;11(6):564-70.
(2007)
Abstract
Holgado S, Toth CA, Freedman SF. Fixation switch and diplopia after full macular translocation surgery. J AAPOS. 2007 Apr;11(2):114-9.
(2007)
Abstract
Muir KW, Duncan L, Enyedi LB, Wallace DK, Freedman SF. Central corneal thickness: congenital cataracts and aphakia. Am J Ophthalmol. 2007 Oct;144(4):502-6.
(2007)
Abstract
O'Malley Schotthoefer E, Yanovitch TL, Freedman SF. Aqueous drainage device surgery in refractory pediatric glaucoma: II. Ocular motility consequence. J AAPOS. 2007 Oct 16.
(2007)
Abstract
O'malley Schotthoefer E, Yanovitch TL, Freedman SF. Aqueous drainage device surgery in refractory pediatric glaucomas: I. Long-term outcomes. J AAPOS. 2007 Oct 15.
(2007)
Abstract
Wallace DK, Freedman SF, Zhao Z, Jung SH. Accuracy of ROPtool vs individual examiners in assessing retinal vascular tortuosity. Arch Ophthalmol. 2007 Nov;125(11):1523-30.
(2007)
Abstract
Wallace DK, Zhao Z, Freedman SF. A pilot study using "ROPtool" to quantify plus disease in retinopathy of prematurity. J AAPOS. 2007 Aug;11(4):381-7.
(2007)
Abstract
Holgado S, Enyedi LB, Toth CA, Freedman SF. Extraocular muscle surgery for extorsion after macular translocation surgery new surgical technique and clinical management. Ophthalmology. 2006 Jan;113(1):63-9.
(2006)
Abstract
Muir KW, Duncan L, Enyedi LB, Freedman SF. Central corneal thickness in children: Racial differences (black vs. white) and correlation with measured intraocular pressure. J Glaucoma. 2006 Dec;15(6):520-3.
(2006)
Abstract
Muir KW, Duncan L, Enyedi LB, Stinnett SS, Freedman SF. Central corneal thickness in children: stability over time. Am J Ophthalmol. 2006 May;141(5):955-7.
(2006)
Abstract
Trigler L, Proia AD, Freedman SF. Fibrovascular ingrowth as a cause of Ahmed glaucoma valve failure in children. Am J Ophthalmol. 2006 Feb;141(2):388-9.
(2006)
Abstract
Cahill MT, Stinnett SS, Banks AD, Freedman SF, Toth CA. Quality of life after macular translocation with 360 degrees peripheral retinectomy for age-related macular degeneration. Ophthalmology. 2005 Jan;112(1):144-51.
(2005)
Abstract
Hess DB, Asrani SG, Bhide MG, Enyedi LB, Stinnett SS, Freedman SF. Macular and retinal nerve fiber layer analysis of normal and glaucomatous eyes in children using optical coherence tomography. Am J Ophthalmol. 2005 Mar;139(3):509-17.
(2005)
Abstract
Tesser R, Hess DB, Freedman SF. Combined intraocular lens implantation and glaucoma implant (tube shunt) surgery in pediatric patients: a case series. J AAPOS. 2005 Aug;9(4):330-5.
(2005)
Abstract
Trigler L, Weaver RG Jr, O'Neil JW, Barondes MJ, Freedman SF. Case series of angle-closure glaucoma after laser treatment for retinopathy of prematurity. J AAPOS. 2005 Feb;9(1):17-21.
(2005)
Abstract
Muir KW, Jin J, Freedman SF. Central corneal thickness and its relationship to intraocular pressure in children. Ophthalmology. 2004 Dec;111(12):2220-3.
(2004)
Abstract
Cahill MT, Freedman SF, Toth CA. Macular translocation with 360 degrees peripheral retinectomy for geographic atrophy. Arch Ophthalmol. 2003 Jan;121(1):132-3.
(2003)
Abstract
Dawn AG, Freedman SF, Lee PP, Enyedi LB. Parents' expectations regarding their children's eye care: interview results. Am J Ophthalmol. 2003 Nov;136(5):797-804.
(2003)
Abstract
Freedman SF, Gearinger MD, Enyedi LB, Holgado S, Toth CA. Measurement of ocular torsion after macular translocation: disc fovea angle and Maddox rod. J AAPOS. 2003 Apr;7(2):103-7.
(2003)
Abstract
Freedman SF, Holgado S, Enyedi LB, Toth CA. Management of ocular torsion and diplopia after macular translocation for age-related macular degeneration: prospective clinical study. Am J Ophthalmol. 2003 Oct;136(4):640-8.
(2003)
Abstract
Enyedi LB, Freedman SF. Latanoprost for the treatment of pediatric glaucoma. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S129-32.
(2002)
Abstract
Freedman SF, Rodriguez-Rosa RE, Rojas MC, Enyedi LB. Goniotomy for glaucoma secondary to chronic childhood uveitis. Am J Ophthalmol. 2002 May;133(5):617-21.
(2002)
Abstract
Freedman SF, Rojas M, Toth CA. Strabismus surgery for large-angle cyclotorsion after macular translocation surgery. J AAPOS. 2002 Jun;6(3):154-62.
(2002)
Abstract
Beck AD, Freedman SF. Trabeculectomy with mitomycin-C in pediatric glaucomas. Ophthalmology. 2001 May;108(5):835-7.
(2001)
Abstract
Enyedi LB, Freedman SF. Safety and efficacy of brimonidine in children with glaucoma. J AAPOS. 2001 Oct;5(5):281-4.
(2001)
Abstract
Toth CA, Freedman SF. Macular translocation with 360-degree peripheral retinectomy impact of technique and surgical experience on visual outcomes. Retina. 2001;21(4):293-303.
(2001)
Abstract
Freedman SF, Seaber JH, Buckley EG, Enyedi LB, Toth CA. Combined superior oblique muscle recession and inferior oblique muscle advancement and transposition for cyclotorsion associated with macular translocation surgery. J AAPOS. 2000 Apr;4(2):75-83.
(2000)
Abstract
Bock CJ Jr, Buckley EG, Freedman SF. Combined resection and recession of a single rectus muscle for the treatment of incomitant strabismus. J AAPOS. 1999 Oct;3(5):263-8.
(1999)
Abstract
Englert JA, Freedman SF, Cox TA. The Ahmed valve in refractory pediatric glaucoma. Am J Ophthalmol. 1999 Jan;127(1):34-42.
(1999)
Abstract
Enyedi LB, Freedman SF, Buckley EG. The effectiveness of latanoprost for the treatment of pediatric glaucoma. J AAPOS. 1999 Feb;3(1):33-9.
(1999)
Abstract
Freedman SF, McCormick K, Cox TA. Mitomycin C-augumented trabeculectomy with postoperative wound modulation in pediatric glaucoma. J AAPOS. 1999 Apr;3(2):117-24.
(1999)
Abstract
Enyedi LB, Peterseim MW, Freedman SF, Buckley EG. Refractive changes after pediatric intraocular lens implantation. Am J Ophthalmol. 1998 Dec;126(6):772-81.
(1998)
Abstract
Portellos M, Buckley EG, Freedman SF. Topical versus oral carbonic anhydrase inhibitor therapy for pediatric glaucoma. J AAPOS. 1998 Feb;2(1):43-7.
(1998)
Abstract
Wagle NS, Freedman SF, Buckley EG, Davis JS, Biglan AW. Long-term outcome of cyclocryotherapy for refractory pediatric glaucoma. Ophthalmology. 1998 Oct;105(10):1921-6; discussion 1926-7.
(1998)
Abstract
Wallace DK, Kylstra JA, Greenman DB, Freedman SF. Significance of isolated neovascular tufts ("popcorn") in retinopathy of prematurity. J AAPOS. 1998 Feb;2(1):52-6.
(1998)
Abstract
Bock CJ, Freedman SF, Buckley EG, Shields MB. Transscleral diode laser cyclophotocoagulation for refractory pediatric glaucomas. J Pediatr Ophthalmol Strabismus. 1997 Jul-Aug;34(4):235-9.
(1997)
Abstract
Freedman SF, Kylstra JA, Capowski JJ, Realini TD, Rich C, Hunt D. Observer sensitivity to retinal vessel diameter and tortuosity in retinopathy of prematurity: a model system. J Pediatr Ophthalmol Strabismus. 1996 Jul-Aug;33(4):248-54.
(1996)
Abstract
Capowski JJ, Kylstra JA, Freedman SF. A numeric index based on spatial frequency for the tortuosity of retinal vessels and its application to plus disease in retinopathy of prematurity. Retina. 1995;15(6):490-500.
(1995)
Abstract
Hall JG, Freedman SF, Kylstra JA. Clinical course and systemic correlates of retinopathy of prematurity in quintuplets. Am J Ophthalmol. 1995 May;119(5):658-60.
(1995)
Abstract
Freedman SF, Freedman NJ, Shields MB, Lobaugh B, Samsa GP, Keates EU, Ollie A. Effects of ocular carteolol and timolol on plasma high-density lipoprotein cholesterol level. Am J Ophthalmol. 1993 Nov 15;116(5):600-11.
(1993)
Abstract
