Physicians

Departments / Divisions

• Radiation Oncology / Radiation Onc-Clinical Sup
• Surgery / Neurosurgery

Address
DUMC 3085
Durham, NC 27710

Appointment Telephone
919-660-2100

Office Telephone
919-668-7342

Fax Telephone
919-668-7345

Training

• MD, University of Texas School of Medicine at San Antonio, 1999

Residency

• Internal Medicine, UNC Hospitals, 1999-2000
• Radiation Oncology, Duke University Medical Center, 2000-2004

Other Training

• PhD, Chemical Engineering, Rice University (Texas), 1979

Clinical Interests
Radiation oncology, particularly the treatment of cancers and benign tumors of the central nervous system, base of skull and head/neck; stereotactic radiosurgery, stereotactic radiotherapy and other highly conformal techniques employing spatiotemporal optimization

Research Interests
Malignant and benign tumors of the brain, spine and base of skull. Mathematical modelling of tumor metabolism, mass transfer and the response to ionizing radiation.  Enhancing clinical outcome in stereotactic radiosurgery, fractionated stereotactic radiotherapy and stereotactic body radiotherapy.

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• BrainLAB
• Genentech, Inc (Roche Holding)
• Varian Medical Systems

Representative Publications
Chang Z, Wang Z, Ma J, O'Daniel JC, Kirkpatrick J, Yin FF. 6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT. Radiother Oncol. 2010 Apr;95(1):116-21. (2010) Abstract

Kelsey CR, Mukundan S Jr, Wang Z, Hahn CA, Soher BJ, Kirkpatrick JP. Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy. Neuro Oncol. 2010 Feb;12(2):145-52. (2010) Abstract

Kirkpatrick JP, van der Kogel AJ, Schultheiss TE. Radiation dose-volume effects in the spinal cord. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S42-9. (2010) Abstract

Mayo C, Martel MK, Marks LB, Flickinger J, Nam J, Kirkpatrick J. Radiation dose-volume effects of optic nerves and chiasm. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S28-35. (2010) Abstract

Sperduto PW, Chao ST, Sneed PK, Luo X, Suh J, Roberge D, Bhatt A, Jensen AW, Brown PD, Shih H, Kirkpatrick J, Schwer A, Gaspar LE, Fiveash JB, Chiang V, Knisely J, Sperduto CM, Mehta M. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):655-61. (2010) Abstract

Hahn CA, Zhou SM, Raynor R, Tisch A, Light K, Shafman T, Wong T, Kirkpatrick J, Turkington T, Hollis D, Marks LB. Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction. Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1082-7. (2009) Abstract

Kirkpatrick JP, Brenner DJ, Orton CG. Point/Counterpoint. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Med Phys. 2009 Aug;36(8):3381-4. (2009) Abstract

Nelson JW, Yoo DS, Sampson JH, Isaacs RE, Larrier NA, Marks LB, Yin FF, Wu QJ, Wang Z, Kirkpatrick JP. Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. Int J Radiat Oncol Biol Phys. 2009 Apr 1;73(5):1369-75. (2009) Abstract

Wang Z, Nelson JW, Yoo S, Wu QJ, Kirkpatrick JP, Marks LB, Yin FF. Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):571-7. (2009) Abstract

Wu QJ, Wang Z, Kirkpatrick JP, Chang Z, Meyer JJ, Lu M, Huntzinger C, Yin FF. Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions. Radiat Oncol. 2009;4:3. (2009) Abstract

Kirkpatrick JP, Dewhirst MW. Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder. Radiat Res. 2008 Mar;169(3):350-4. (2008) Abstract

Kirkpatrick JP, Meyer JJ, Marks LB. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Semin Radiat Oncol. 2008 Oct;18(4):240-3. (2008) Abstract

Kirkpatrick JP, Rabbani ZN, Bentley RC, Hardee ME, Karol S, Meyer J, Oosterwijk E, Havrilesky L, Secord AA, Vujaskovic Z, Dewhirst MW, Jones EL. Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer. Biomark Insights. 2008;3:45-55. (2008) Abstract

Kasibhatla M, Kirkpatrick JP, Brizel DM. How much radiation is the chemotherapy worth in advanced head and neck cancer? Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1491-5. (2007) Abstract

Hardee ME, Arcasoy MO, Blackwell KL, Kirkpatrick JP, Dewhirst MW. Erythropoietin biology in cancer. Clin Cancer Res. 2006 Jan 15;12(2):332-9. (2006) Abstract

Kirkpatrick JP, Hardee ME, Snyder SA, Peltz CM, Zhao Y, Brizel DM, Dewhirst MW, Blackwell KL. The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. Radiat Res. 2006 Feb;165(2):192-201. (2006) Abstract

Kirkpatrick JP. Tumor hypoxia and prognosis in human gliomas. Cancer J. 2006 Nov-Dec;12(6):451-4. (2006) Abstract

Koontz BF, Kirkpatrick JP, Clough RW, Prosnitz RG, Gockerman JP, Moore JO, Prosnitz LR. Combined-modality therapy versus radiotherapy alone for treatment of early-stage Hodgkin's disease: cure balanced against complications. J Clin Oncol. 2006 Feb 1;24(4):605-11. (2006) Abstract

Meyer JJ, Marks LB, Halperin EC, Kirkpatrick JP. Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. Radiat Oncol. 2006;1:48. (2006) Abstract

Soper JT, Spillman M, Sampson JH, Kirkpatrick JP, Wolf JK, Clarke-Pearson DL. High-risk gestational trophoblastic neoplasia with brain metastases: Individualized multidisciplinary therapy in the management of four patients. Gynecol Oncol. 2006 Nov 28. (2006) Abstract

Yin FF, Das S, Kirkpatrick J, Oldham M, Wang Z, Zhou SM. Physics and imaging for targeting of oligometastases. Semin Radiat Oncol. 2006 Apr;16(2):85-101. (2006) Abstract

Hardee ME, Kirkpatrick JP, Shan S, Snyder SA, Vujaskovic Z, Rabbani ZN, Dewhirst MW, Blackwell KL. Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. Br J Cancer. 2005 Dec 12;93(12):1350-5. (2005) Abstract

Kirkpatrick JP, Anscher MS. Radiotherapy for locally recurrent prostate cancer. Clin Adv Hematol Oncol. 2005 Dec;3(12):933-42. (2005) Abstract

Kirkpatrick JP, Cárdenas-Navia LI, Dewhirst MW. Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):822-33. (2004) Abstract

Kirkpatrick JP, Marks LB. Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data. Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):641-54. (2004) Abstract

Blackwell KL, Kirkpatrick JP, Snyder SA, Broadwater G, Farrell F, Jolliffe L, Brizel DM, Dewhirst MW. Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin. Cancer Res. 2003 Oct 1;63(19):6162-5. (2003) Abstract

Kang SK, Kirkpatrick JP, Halperin EC. Low-dose radiation for posttransplant lymphoproliferative disorder. Am J Clin Oncol. 2003 Apr;26(2):210-4. (2003) Abstract

Kirkpatrick JP, Brizel DM, Dewhirst MW. A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. Radiat Res. 2003 Mar;159(3):336-44. (2003) Abstract

Kirkpatrick JP, McIntire LV, Moake JL, Cimo PL. Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. Thromb Haemost. 1980 Feb 29;42(5):1483-9. (1980) Abstract

Kirkpatrick JP, McIntire LV, Moake JL, Peterson DM. Metabolic requirements of contractile force generation in platelet rich plasma - a rheological study. Biorheology. 1980;17(5-6):411-8. (1980) Abstract

Kirkpatrick JP, McIntire LV, Moake JL. Streptokinase-induced degradation of crosslinked and uncrosslinked clots. Thromb Res. 1978 Sep;13(3):569-75. (1978) Abstract