Durham, NC 27710
Diagnosis, treatment and the study of hereditary forms of osteoarthritis; development of biomarkers for arthritis; clinical trials of new therapeutics for osteoarthritis
My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.
The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Kraus, VB. Osteoarthritis year 2010 in review: biochemical markers. Osteoarthritis and Cartilage. 2011;19:346-353. (2011) Abstract
Kraus, VB; Burnett, B; Coindreau, J; Cottrell, S; Eyre, D; Gendreau, M; Gardiner, J; Garnero, P; Hardin, J; Henrotin, Y; Heinegård, D; Ko, A; Lohmander, LS; Matthews, G; Menetski, J; Moskowitz, R; Persiani, S; Poole, AR; Rousseau, JC; Todman, M; Group, OARSIFDAOBW. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthritis and Cartilage. 2011; (2011) Abstract
Pells, JJ; Shelby, RA; Keefe, FJ; Dixon, KE; Blumenthal, JA; Lacaille, L; Tucker, JM; Schmitt, D; Caldwell, DS; Kraus, VB. Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain. Pain. 2008;136:340-347. (2008) Abstract
Allen, KD; DeVellis, RF; Renner, JB; Kraus, VB; Jordan, JM. Validity and factor structure of the AUSCAN Osteoarthritis Hand Index in a community-based sample. Osteoarthritis and Cartilage. 2007;15:830-836. (2007) Abstract
Charles, HC; Kraus, VB; Ainslie, M; Hellio Le Graverand-Gastineau, MP. Optimization of the fixed-flexion knee radiograph. Osteoarthritis and Cartilage. 2007;15:1221-1224. (2007) Abstract
Elliott, AL; Kraus, VB; Fang, F; Renner, JB; Schwartz, TA; Salazar, A; Huguenin, T; Hochberg, MC; Helmick, CG; Jordan, JM. Joint-specific hand symptoms and self-reported and performance-based functional status in African Americans and Caucasians: The Johnston County Osteoarthritis Project. Annals of the Rheumatic Diseases. 2007;66:1622-1626. (2007) Abstract
Huebner, JL; Seifer, DR; Kraus, VB. A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis. Osteoarthritis and Cartilage. 2007;15:354-356. (2007) Abstract
Kraus, VB; Jordan, JM; Doherty, M; Wilson, AG; Moskowitz, R; Hochberg, M; Loeser, R; Hooper, M; Renner, JB; Crane, MM; Hastie, P; Sundseth, S; Atif, U. The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis and Cartilage. 2007;15:120-127. (2007) Abstract
Kraus, VB; Stabler, TV; Kong, SY; Varju, G; McDaniel, G. Measurement of synovial fluid volume using urea. Osteoarthritis and Cartilage. 2007;15:1217-1220. (2007) Abstract
Kraus, VB; Stabler, TV; Luta, G; Renner, JB; Dragomir, AD; Jordan, JM. Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis. Osteoarthritis and Cartilage. 2007;15:966-971. (2007) Abstract
Shamji, MF; Betre, H; Kraus, VB; Chen, J; Chilkoti, A; Pichika, R; Masuda, K; Setton, LA. Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. Arthritis and Rheumatism. 2007;56:3650-3661. (2007) Abstract
Bauer, DC; Hunter, DJ; Abramson, SB; Attur, M; Corr, M; Felson, D; Heinegård, D; Jordan, JM; Kepler, TB; Lane, NE; Saxne, T; Tyree, B; Kraus, VB; Osteoarthritis Biomarkers Network. Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthritis and Cartilage. 2006;14:723-727. (2006) Abstract
Huebner, JL; Kraus, VB. Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. Osteoarthritis and Cartilage. 2006;14:923-930. (2006) Abstract
Kong, SY; Stabler, TV; Criscione, LG; Elliott, AL; Jordan, JM; Kraus, VB. Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. Arthritis and Rheumatism. 2006;54:2496-2504. (2006) Abstract
Kraus, VB. Do biochemical markers have a role in osteoarthritis diagnosis and treatment?. Best Practice and Research: Clinical Rheumatology. 2006;20:69-80. (2006) Abstract
Criscione, LG; Elliott, AL; Stabler, T; Jordan, JM; Pieper, CF; Kraus, VB. Variation of serum hyaluronan with activity in individuals with knee osteoarthritis. Osteoarthritis and Cartilage. 2005;13:837-840. (2005) Abstract
Clark, AG; Rohrbaugh, AL; Otterness, I; Kraus, VB. The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants. Matrix Biology. 2002;21:175-184. (2002) Abstract
Huebner, JL; Hanes, MA; Beekman, B; TeKoppele, JM; Kraus, VB. A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis. Osteoarthritis and Cartilage. 2002;10:758-767. (2002) Abstract
Kraus, VB; Huebner, JL; Fink, C; King, JB; Brown, S; Vail, TP; Guilak, F. Urea as a passive transport marker for arthritis biomarker studies. Arthritis and Rheumatism. 2002;46:420-427. (2002) Abstract