Physicians

Department / Division
Pathology / Pathology Clinical Services

Address
DUMC 3712
Durham, NC 27710

Office Telephone
919-684-6423

Fax Telephone
919-681-7634

Training

• MD, Harvard Medical School (Massachusetts), 1986

Residency

• Pathology, Duke University Medical Center, 1986-1992

Fellowship

• Surgical Pathology, Duke University Medical Center, 1992-1993

Clinical Interests
General surgical pathology; gynecologic, breast, and obstetric pathology; electron microscopy of tumors

Research Interests
Outcome-based research on pathology of endometrial carcinoma, including prognostic significance of histologic features of endometrial carcinoma, variants of endometrial carcinoma, definitions of atypia and well-differentiated carcinoma, and collaborative studies of oncogenes and tumor suppressor genes in endometrial carcinoma.

Endometrial pathology, especially as it relates to molecular/genetic alterations in neoplasms.

Ovarian pathology, especially as it relates to molecular and genetic alterations in neoplasms.

Improving accuracy of radiographic screening for breast cancer, by careful patho-radiographic correlation and study of improved imaging techniques (especially ultrasound).

Use of electron microscopy as a diagnostic and research technique.

Objective measures of pathology resident performance.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Bentley, RC. Pathology of gestational trophoblastic disease. Clinical Obstetrics and Gynecology. 2003;46:513-522. (2003) Abstract

Lancaster, JM; Wenham, RM; Halabi, S; Calingaert, B; Marks, JR; Moorman, PG; Bentley, RC; Berchuck, A; Schildkraut, JM. No relationship between ovarian cancer risk and progesterone receptor gene polymorphism in a population-based, case-control study in North Carolina. Cancer Epidemiology, Biomarkers and Prevention. 2003;12:226-227. (2003) Abstract

Wenham, RM; Calingaert, B; Ali, S; McClean, K; Whitaker, R; Bentley, R; Lancaster, JM; Schildkraut, J; Marks, J; Berchuck, A. Matrix metalloproteinase-1 gene promoter polymorphism and risk of ovarian cancer. Reproductive Sciences. 2003;10:381-387. (2003) Abstract

Rodriguez, GC; Nagarsheth, NP; Lee, KL; Bentley, RC; Walmer, DK; Cline, M; Whitaker, RS; Isner, P; Berchuck, A; Dodge, RK; Hughes, CL. Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta. Journal of the National Cancer Institute. 2002;94:50-60. (2002) Abstract

Rosen, EL; Bentley, RC; Baker, JA; Soo, MS. Imaging-guided core needle biopsy of papillary lesions of the breast. American Journal of Roentgenology. 2002;179:1185-1192. (2002) Abstract

Alvarez, AA; Axelrod, JR; Whitaker, RS; Isner, PD; Bentley, RC; Dodge, RK; Rodriguez, GC. Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients. Gynecologic Oncology. 2001;82:273-278. (2001) Abstract

Alvarez, AA; Moore, WF; Robboy, SJ; Bentley, RC; Gumbs, C; Futreal, PA; Berchuck, A. K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary. Gynecologic Oncology. 2001;80:201-206. (2001) Abstract

Harris, LN; Liotcheva, V; Broadwater, G; Ramirez, MJ; Maimonis, P; Anderson, S; Everett, T; Harpole, D; Moore, MB; Berry, DA; Rizzeri, D; Vredenburgh, JJ; Bentley, RC. Comparison of methods of measuring HER-2 in metastatic breast cancer patients treated with high-dose chemotherapy. Journal of Clinical Oncology. 2001;19:1698-1706. (2001) Abstract

Stern, RC; Dash, R; Bentley, RC; Snyder, MJ; Haney, AF; Robboy, SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. International Journal of Gynecological Pathology. 2001;20:133-139. (2001) Abstract

White, RR; Halperin, TJ; Olson, JA; Soo, MS; Bentley, RC; Seigler, HF. Impact of core-needle breast biopsy on the surgical management of mammographic abnormalities. Annals of Surgery. 2001;233:769-777. (2001) Abstract

Cirisano, FD; Robboy, SJ; Dodge, RK; Bentley, RC; Krigman, HR; Synan, IS; Soper, JT; Clarke-Pearson, DL. The outcome of stage I-II clinically and surgically staged papillary serous and clear cell endometrial cancers when compared with endometrioid carcinoma. Gynecologic Oncology. 2000;77:55-65. (2000) Abstract

Moore, WF; Bentley, RC; Berchuck, A; Robboy, SJ. Some mullerian inclusion cysts in lymph nodes may sometimes be metastases from serous borderline tumors of the ovary. American Journal of Surgical Pathology. 2000;24:710-718. (2000) Abstract

Robboy, SJ; Bentley, RC; Butnor, K; Anderson, MC. Pathology and pathophysiology of uterine smooth-muscle tumors. Environmental Health Perspectives. 2000;108 Suppl 5:779-784. (2000) Abstract

Soo, MS; Dash, N; Bentley, R; Lee, LH; Nathan, G. Tubular adenomas of the breast: imaging findings with histologic correlation. American Journal of Roentgenology. 2000;174:757-761. (2000) Abstract

Cirisano, FD; Robboy, SJ; Dodge, RK; Bentley, RC; Krigman, HR; Synan, IS; Soper, JT; Clarke-Pearson, DL. Epidemiologic and surgicopathologic findings of papillary serous and clear cell endometrial cancers when compared to endometrioid carcinoma. Gynecologic Oncology. 1999;74:385-394. (1999) Abstract

Rosen, EL; Soo, MS; Bentley, RC. Focal fibrosis: a common breast lesion diagnosed at imaging-guided core biopsy. American Journal of Roentgenology. 1999;173:1657-1662. (1999) Abstract

Maxwell, GL; Risinger, JI; Gumbs, C; Shaw, H; Bentley, RC; Barrett, JC; Berchuck, A; Futreal, PA. Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias. Cancer Research. 1998;58:2500-2503. (1998) Abstract

Moore, WF; Bentley, RC; Kim, KR; Olatidoye, B; Gray, SR; Robboy, SJ. Goblet-cell mucinous epithelium lining the endometrium and endocervix: evidence of metastasis from an appendiceal primary tumor through the use of cytokeratin-7 and -20 immunostains. International Journal of Gynecological Pathology. 1998;17:363-367. (1998) Abstract

Zaino, RJ; Kurman, RJ; Brunetto, VL; Morrow, CP; Bentley, RC; Cappellari, JO; Bitterman, P. Villoglandular adenocarcinoma of the endometrium: a clinicopathologic study of 61 cases: a gynecologic oncology group study. American Journal of Surgical Pathology. 1998;22:1379-1385. (1998) Abstract

Anderson, ME; Soo, MS; Bentley, RC; Trahey, GE. The detection of breast microcalcifications with medical ultrasound. Journal of the Acoustical Society of America. 1997;101:29-39. (1997) Abstract

Couchman, GM; Bentley, R; Tsao, MS; Raszmann, K; McLachlan, JA; Walmer, DK. p53lyn and p56lyn: a new signaling pathway in human endometrium and endometrial adenocarcinomas. Reproductive Sciences. 1997;4:103-109. (1997) Abstract

Hansard, LJ; Healy-Gardner, BE; Drapkin, AT; Bentley, RC; McLachlan, JA; Walmer, DK. Human endometrial transforming growth factor-alpha: a transmembrane, surface epithelial protein that transiently disappears during the midsecretory phase of the menstrual cycle. Reproductive Sciences. 1997;4:160-166. (1997) Abstract

Mooney, EE; Robboy, SJ; Hammond, CB; Berchuck, A; Bentley, RC. Signet-ring cell carcinoma of the endometrium: a primary tumor masquerading as a metastasis. International Journal of Gynecological Pathology. 1997;16:169-172. (1997) Abstract

Walsh, R; Kornguth, PJ; Soo, MS; Bentley, R; DeLong, DM. Axillary lymph nodes: mammographic, pathologic, and clinical correlation. American Journal of Roentgenology. 1997;168:33-38. (1997) Abstract

Washington, K; Bentley, RC; Green, A; Olson, J; Treem, WR; Krigman, HR. Gastric graft-versus-host disease: a blinded histologic study. American Journal of Surgical Pathology. 1997;21:1037-1046. (1997) Abstract

Hankins, GR; De Souza, AT; Bentley, RC; Patel, MR; Marks, JR; Iglehart, JD; Jirtle, RL. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Oncogene. 1996;12:2003-2009. (1996) Abstract

Ibrahim, SN; Krigman, HR; Coogan, AC; Wax, TD; Dodd, LG; Bentley, RC; Robboy, SJ; Johnston, WW. Prospective correlation of cervicovaginal cytologic and histologic specimens. American Journal of Clinical Pathology. 1996;106:319-324. (1996) Abstract

Yelverton, CL; Bentley, RC; Olenick, S; Krigman, HR; Johnston, WW; Robboy, SJ. Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis. International Journal of Gynecological Pathology. 1996;15:338-344. (1996) Abstract

Prade, M; Spatz, A; Bentley, R; Duvillard, P; Bognel, C; Robboy, SJ. Borderline and malignant serous tumor arising in pelvic lymph nodes: evidence of origin in benign glandular inclusions. International Journal of Gynecological Pathology. 1995;14:87-91. (1995) Abstract

Soo, MS; Williford, ME; Walsh, R; Bentley, RC; Kornguth, PJ. Papillary carcinoma of the breast: imaging findings. American Journal of Roentgenology. 1995;164:321-326. (1995) Abstract

Usadi, RS; Bentley, RC. Endometrioid carcinoma of the endometrium with sertoliform differentiation. International Journal of Gynecological Pathology. 1995;14:360-364. (1995) Abstract

Walmer, DK; Padin, CJ; Wrona, MA; Healy, BE; Bentley, RC; Tsao, MS; Kohler, MF; McLachlan, JA; Gray, KD. Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein. Cancer Research. 1995;55:1168-1175. (1995) Abstract

Krigman, H; Bentley, R; Robboy, SJ. Pathology of epithelial ovarian tumors. Clinical Obstetrics and Gynecology. 1994;37:475-491. (1994) Abstract

Lukes, AS; Kohler, MF; Pieper, CF; Kerns, BJ; Bentley, R; Rodriguez, GC; Soper, JT; Clarke-Pearson, DL; Bast, RC; Berchuck, A. Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer. Cancer. 1994;73:2380-2385. (1994) Abstract

Robboy, SJ; Bentley, RC; Krigman, H; Silverberg, SG; Norris, HJ; Zaino, RJ. Synoptic reports in gynecologic pathology. International Journal of Gynecological Pathology. 1994;13:161-174. (1994) Abstract

Bentley, RC; Keene, JD. Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein. Molecular and Cellular Biology. 1991;11:1829-1839. (1991) Abstract

Query, CC; Bentley, RC; Keene, JD. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell. 1989;57:89-101. (1989) Abstract

Query, CC; Bentley, RC; Keene, JD. A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component. Molecular and Cellular Biology. 1989;9:4872-4881. (1989) Abstract

Heinrich, G; Gros, P; Lund, PK; Bentley, RC; Habener, JF. Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology. 1984;115:2176-2181. (1984) Abstract