Physicians

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC 3132
Durham, NC 27710

Appointment Telephone
919-668-7630

Office Telephone
919-681-8551

Fax Telephone
919-684-8951

Training

• MD, University of Chicago Pritzker School of Medicine (Illinois), 1989

Residency

• Internal Medicine, Yale-New Haven Hospital (Connecticut), 1989-1992

Fellowship

• Pulmonary-Critical Care, Duke University Medical Center, 1993-1996

Clinical Interests
COPD, asthma, lung cancer evaluation, interstitial lung disease, sarcoidosis, critical care medicine

Research Interests
My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.


Key words: nitrosative defense, lung injury, nitric oxide

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Wahidi, MM; Silvestri, GA; Coakley, RD; Ferguson, JS; Shepherd, RW; Moses, L; Conforti, J; Que, LG; Anstrom, KJ; McGuire, F; Colt, H; Downie, GH. A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows. Chest. 2010;137:1040-1049. (2010) Abstract

Chudgar, SM; Cox, CE; Que, LG; Andolsek, K; Knudsen, NW; Clay, AS. Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit?. Critical Care Medicine. 2009;37:49-60. (2009) Abstract

Que, LG; Yang, Z; Stamler, JS; Lugogo, NL; Kraft, M. S-nitrosoglutathione reductase: an important regulator in human asthma. American Journal of Respiratory and Critical Care Medicine. 2009;180:226-231. (2009) Abstract

Clay, AS; Que, L; Petrusa, ER; Sebastian, M; Govert, J. Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching. Critical Care Medicine. 2007;35:738-754. (2007) Abstract

Lugogo, NL; Ginsburg, GS; Que, LG. Genetic profiling and tailored therapy in asthma: are we there yet?. Current Opinion in Molecular Therapeutics. 2007;9:528-537. (2007) Abstract

Whalen, EJ; Foster, MW; Matsumoto, A; Ozawa, K; Violin, JD; Que, LG; Nelson, CD; Benhar, M; Keys, JR; Rockman, HA; Koch, WJ; Daaka, Y; Lefkowitz, RJ; Stamler, JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007;129:511-522. (2007) Abstract

Que, LG; Liu, L; Yan, Y; Whitehead, GS; Gavett, SH; Schwartz, DA; Stamler, JS. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005;308:1618-1621. (2005) Abstract

Liu, L; Yan, Y; Zeng, M; Zhang, J; Hanes, MA; Ahearn, G; McMahon, TJ; Dickfeld, T; Marshall, HE; Que, LG; Stamler, JS. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004;116:617-628. (2004) Abstract

Que, LG; George, SE; Gotoh, T; Mori, M; Huang, YC. Effects of arginase isoforms on NO Production by nNOS. Nitric Oxide: Biology and Chemistry. 2002;6:1-8. (2002) Abstract

Yu, Q; Que, LG; Rockey, DC. Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver. American Journal of Physiology: Gastrointestinal and Liver Physiology. 2002;282:G565-G572. (2002) Abstract

Liu, L; Hausladen, A; Zeng, M; Que, L; Heitman, J; Stamler, JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature. 2001;410:490-494. (2001) Abstract

Liu, L; Hausladen, A; Zeng, M; Que, L; Heitman, J; Stamler, JS; Steverding, D. Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase. Redox Report. 2001;6:209-210. (2001) Abstract

Que, LG; Tony Huang, YC. Pharmacologic adjuncts during mechanical ventilation. Seminars in Respiratory and Critical Care Medicine: pulmonology, critical care, allergy and immunology, infections. 2000;21:223-232. (2000) Abstract

Lau, CL; Bentley, RC; Gockerman, JP; Que, LG; D'Amico, TA. Malignant melanoma presenting as a mediastinal mass. Annals of Thoracic Surgery. 1999;67:851-852. (1999) Abstract

Carraway, MS; Welty-Wolf, KE; Kantrow, SP; Huang, YC; Simonson, SG; Que, LG; Kishimoto, TK; Piantadosi, CA. Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. American Journal of Respiratory and Critical Care Medicine. 1998;157:938-949. (1998) Abstract

Que, LG; Kang, BH; Huang, YC; Piantadosi, CA; Chang, LY. Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. Shock. 1998;9:304-309. (1998) Abstract

Que, LG; Kantrow, SP; Jenkinson, CP; Piantadosi, CA; Huang, YC. Induction of arginase isoforms in the lung during hyperoxia. American Journal of Physiology. 1998;275:L96-102. (1998) Abstract