Department / Division:
Medicine / Pulmonary, Allergy, and Critical Care Medicine

Address:
DUMC 3132
Durham, NC 27710

Appointment Telephone:
919-668-7630

Office Telephone:
919-681-8551

Fax Telephone:
919-684-8951

• MD, University of Chicago Pritzker School of Medicine (Illinois), 1989

• Internal Medicine, Yale-New Haven Hospital (Connecticut), 1989-1992

• Pulmonary/Critical Care, Duke University Medical Center, 1993-1996

Clinical Interests:
COPD, asthma, lung cancer evaluation, interstitial lung disease, sarcoidosis, critical care medicine

Research Interests:
My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and then applied to animal models of disease and examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale basis for targeted therapeutic use of NO.


Key words: nitrosative defense, lung injury, nitric oxide

Representative Publications:
Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007 May 4;129(3):511-22. (2007) Abstract

Lugogo NL, Ginsburg GS, Que LG. Genetic profiling and tailored therapy in asthma: Are we there yet?  Curr Opin Mol Ther.  2007 Dec;9(6):528-37. (2007) Abstract

Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, Stamler JS. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005 Jun 10;308(5728):1618-21. (2005) Abstract

Liu L, Yan Y, Zeng M, Zhang J, Hanes MA, Ahearn G, McMahon TJ, Dickfeld T, Marshall HE, Que LG, Stamler JS. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004 Feb 20;116(4):617-28. (2004) Abstract

Que, LG*, Marshall, HE*, Stamler, JSS, and Gaston, B. S-Nitrosothiols in Lung Inflammation. Therapeutic Targets of Airway Inflammation: Eissa/Huston. Lung Biology in Health and Disease Series, Marcel Dekker, Inc., NY, NY (2003).*Both authors contributed equally to this work. (2003)

Yu Q, Que LG, Rockey DC. Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver. Am J Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G565-72. (2002) Abstract

Que LG, George SE, Gotoh T, Mori M, Huang YC. Effects of arginase isoforms on NO Production by nNOS. Nitric Oxide. 2002 Feb;6(1):1-8. (2002) Abstract

Que, LG*, Marshall, HE*, Stamler, JSS, and Gaston, B. S-Nitrosothiols in Lung Inflammation. Therapeutic Targets of Airway Inflammation: Eissa/Huston. Lung Biology in Health and Disease Series, Marcel Dekker, Inc., NY, NY (2003).*Both authors contributed equally to this work. (2001)

Que, LG and YCT Huang.   Pharmacologic Adjuncts to Mechanical Ventilation. Seminars in Respiratory and Critical Care Medicine, 21.3, 2000. (2001)

Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J. and Stamler, J.S.  A metabolic enzyme for S-Nitrosothiol conserved from bacteria to humans.  Nature 410: 490-494, 2001 Mar. (2001)

Que LG, Tony Huang YC. Pharmacologic adjuncts during mechanical ventilation.  Semin Respir Crit Care Med.  2000;21(3):223-32. (2000) Abstract

Que LG, Kantrow SP, Jenkinson CP, Piantadosi CA, Huang YC. Induction of arginase isoforms in the lung during hyperoxia. Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102. (1998) Abstract

Que LG, Kang BH, Huang YC, Piantadosi CA, Chang LY. Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. Shock. 1998 Apr;9(4):304-9. (1998) Abstract

Carraway MS, Welty-Wolf KE, Kantrow SP, Huang YC, Simonson SG, Que LG, Kishimoto TK, Piantadosi CA. Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):938-49. (1998) Abstract