Physicians

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC 3132
Durham, NC 27710

Appointment Telephone
919-668-7630

Office Telephone
919-681-8551

Fax Telephone
919-684-8951

Training

• MD, University of Chicago Pritzker School of Medicine (Illinois), 1989

Residency

• Internal Medicine, Yale-New Haven Hospital (Connecticut), 1989-1992

Fellowship

• Pulmonary/Critical Care, Duke University Medical Center, 1993-1996

Clinical Interests
COPD, asthma, lung cancer evaluation, interstitial lung disease, sarcoidosis, critical care medicine

Research Interests
My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.


Key words: nitrosative defense, lung injury, nitric oxide

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Amgen, Inc.
• Auxilium Pharmaceuticals, Inc.
• Guidepoint Clinical
• Lilly (Eli Lilly)
• Novartis
• Roche Diagnostics

Representative Publications
Chudgar SM, Cox CE, Que LG, Andolsek K, Knudsen NW, Clay AS. Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit? Crit Care Med. 2009 Jan;37(1):49-60. (2009) Abstract

Que LG, Yang Z, Stamler JS, Lugogo NL, Kraft M. S-nitrosoglutathione reductase: an important regulator in human asthma. Am J Respir Crit Care Med. 2009 Aug 1;180(3):226-31. (2009) Abstract

Wahidi MM, Silvestri GA, Coakley RD, Ferguson JS, Shepherd RW, Moses L, Conforti J, Que L, Anstrom KJ, McGuire F, Colt H, Downie GH. "A prospective multi-center study of competency metrics and educational interventions in the learning of bronchoscopy among starting pulmonary fellows" Chest. 2009 Oct 26. (2009) Abstract

Clay AS, Que L, Petrusa ER, Sebastian M, Govert J. Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching. Crit Care Med. 2007 Mar;35(3):738-54. (2007) Abstract

Lugogo NL, Ginsburg GS, Que LG. Genetic profiling and tailored therapy in asthma: are we there yet? Curr Opin Mol Ther. 2007 Dec;9(6):528-37. (2007) Abstract

Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 2007 May 4;129(3):511-22. (2007) Abstract

Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, Stamler JS. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005 Jun 10;308(5728):1618-21. (2005) Abstract

Liu L, Yan Y, Zeng M, Zhang J, Hanes MA, Ahearn G, McMahon TJ, Dickfeld T, Marshall HE, Que LG, Stamler JS. Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004 Feb 20;116(4):617-28. (2004) Abstract

Que, LG*, Marshall, HE*, Stamler, JSS, and Gaston, B. S-Nitrosothiols in Lung Inflammation. Therapeutic Targets of Airway Inflammation: Eissa/Huston. Lung Biology in Health and Disease Series, Marcel Dekker, Inc., NY, NY (2003).*Both authors contributed equally to this work. (2003)

Que LG, George SE, Gotoh T, Mori M, Huang YC. Effects of arginase isoforms on NO Production by nNOS. Nitric Oxide. 2002 Feb;6(1):1-8. (2002) Abstract

Yu Q, Que LG, Rockey DC. Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver. Am J Physiol Gastrointest Liver Physiol. 2002 Mar;282(3):G565-72. (2002) Abstract

Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS, Steverding D. Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase. Redox Rep. 2001;6(4):209-10. (2001) Abstract

Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature. 2001 Mar 22;410(6827):490-4. (2001) Abstract

Que LG, Tony Huang YC. Pharmacologic adjuncts during mechanical ventilation. Semin Respir Crit Care Med. 2000;21(3):223-32. (2000) Abstract

Lau CL, Bentley RC, Gockerman JP, Que LG, D'Amico TA. Malignant melanoma presenting as a mediastinal mass. Ann Thorac Surg. 1999 Mar;67(3):851-2. (1999) Abstract

Carraway MS, Welty-Wolf KE, Kantrow SP, Huang YC, Simonson SG, Que LG, Kishimoto TK, Piantadosi CA. Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons. Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):938-49. (1998) Abstract

Que LG, Kang BH, Huang YC, Piantadosi CA, Chang LY. Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. Shock. 1998 Apr;9(4):304-9. (1998) Abstract

Que LG, Kantrow SP, Jenkinson CP, Piantadosi CA, Huang YC. Induction of arginase isoforms in the lung during hyperoxia. Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102. (1998) Abstract