John H.P. Alexander, MD, MHS
Department / Division
Medicine /
Medicine - Cardiology
Address
DUMC 3300
Durham, NC 27710
Appointment Telephone
919-681-5816
Office Telephone
919-681-5816
Fax Telephone
919-681-0811
- MD, University of Pennsylvania School of Medicine, 1993
- Internal Medicine, Brigham and Women's Hospital (Massachusetts), 1993-1996
- Cardiovascular Disease, Duke University Medical Center, 1996-2000
- MHS, Duke University, 2001
Clinical Interests
General adult cardiology, acute and general cardiovascular disease, coronary artery disease, chest pain, unstable angina, myocardial infarction, acute coronary syndromes, heart failure, hypertension, echocardiography, transesophageal echocardiography, stress echocardiography, valvular heart disease
Research Interests
My major research interests are in the pathyophysiology and therapeutics of acute coronary syndromes and chronic coronary artery disease with a particular interest in clinical research in cardiac surgery. Methodologically, I focus on early phase clinical research and site based research techniques.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Bayer Healthcare
- Boeringer Ingelheim
- Bristol Myers Squibb
- CLS Behring
- Daiichi Sankyo
- Janssen Pharmaceuticals (Johnson & Johnson)
- Moerae Matrix
- Novartis
- Orexigen Therapeutics, Inc.
- Pfizer Inc.
- Regado Biosciences
- Somahlution
- Xoma Pharmaceuticals
Representative Publications
Serebruany, VL; Malinin, AI; Callahan, KP; Binbrek, A; Van De Werf, F; Alexander, JH; Granger, CB; Gurbel, PA; Assessment of the Safety and Efficacy of a New Thrombolytic Agent platelet substudy. Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy. American Heart Journal. 2003;145:636-642.
(2003)
Abstract
Akkerhuis, KM; Alexander, JH; Tardiff, BE; Boersma, E; Harrington, RA; Lincoff, AM; Simoons, ML. Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different?. Circulation. 2002;105:554-556.
(2002)
Abstract
Al-Khatib, SM; Califf, RM; Hasselblad, V; Alexander, JH; McCrory, DC; Sugarman, J. Medicine. Placebo-controls in short-term clinical trials of hypertension. Science. 2001;292:2013-2015.
(2001)
Abstract
Angeja, BG; Alexander, JH; Chin, R; Li, X; Barron, HV; Armstrong, PW; Granger, CB; Van de Werf, F; Gibson, CM. Safety of the weight-adjusted dosing regimen of tenecteplase in the ASSENT-Trial. American Journal of Cardiology. 2001;88:1240-1245.
(2001)
Abstract
Callahan, KP; Malinin, AI; Gurbel, PA; Alexander, JH; Granger, CB; Serebruany, VL. Platelet function and fibrinolytic agents: two sides of a coin?. Cardiology: international journal of cardiovascular medicine, surgery and pathology. 2001;95:55-60.
(2001)
Abstract
Alexander, JH; Sparapani, RA; Mahaffey, KW; Deckers, JW; Newby, LK; Ohman, EM; Corbalan, R; Chierchia, SL; Boland, JB; Simoons, ML; Califf, RM; Topol, EJ; Harrington, RA. Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation. PURSUIT Steering Committee. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy. JAMA: Journal of the American Medical Association. 2000;283:347-353.
(2000)
Abstract
Patel, M; Han, SS; Vaux, K; Saalfeld, J; Alexander, JH. A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs. ANZ Journal of Surgery. 2000;70:39-42.
(2000)
Abstract
Alexander, JH; Al-Khatib, S; Cantor, W; Greenbaum, AB; Hudson, MP; Kong, DF; Shah, M. Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999. American Heart Journal. 1999;138:175-190.
(1999)
Abstract
Alexander, JH; Granger, CB; Sadowski, Z; Aylward, PE; White, HD; Thompson, TD; Califf, RM; Topol, EJ. Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators. American Heart Journal. 1999;137:799-805.
(1999)
Abstract
Alexander, JH; Harrington, RA; Tuttle, RH; Berdan, LG; Lincoff, AM; Deckers, JW; Simoons, ML; Guerci, A; Hochman, JS; Wilcox, RG; Kitt, MM; Eisenberg, PR; Califf, RM; Topol, EJ; Karsh, K; Ruzyllo, W; Stepinska, J; Widimsky, P; Boland, JB; Armstrong, PW. Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy. American Journal of Cardiology. 1999;83:1147-1151.
(1999)
Abstract
Alexander, JH; Kong, DF; Cantor, WJ. Highlights from the 71st American Heart Association Scientific Sessions: November 8 to 11, 1998. American Heart Journal. 1999;137:555-574.
(1999)
Abstract
Pertusi, RM; Godwin, KS; House, JK; Knebl, JA; Alexander, JH; Rubin, BR; Forman, MD. Gastropathy induced by nonsteroidal anti-inflammatory drugs: prescribing patterns among geriatric practitioners. JAOA: Journal of the American Osteopathic Association. 1999;99:305-310.
(1999)
Abstract
Sadowski, ZP; Alexander, JH; Skrabucha, B; Dyduszynski, A; Kuch, J; Nartowicz, E; Swiatecka, G; Kong, DF; Granger, CB. Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction. American Heart Journal. 1999;137:792-798.
(1999)
Abstract
Alexander, JH; Alexander, K; Kong, DF; Tung, CY; Whellan, D. Session highlights from the American Heart Association Scientific Sessions: November 9-12, 1997. American Heart Journal. 1998;135:157-180.
(1998)
Abstract
Alexander, JH; Greenbaum, AB; Hudson, MP; Kong, DF; Miller, JM; Tung, CY; Whellan, DJ. Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998. American Heart Journal. 1998;135:1099-1114.
(1998)
Abstract
Alexander, JH; Greenbaum, AB; Hudson, MP; Kong, DF; Miller, JM; Tung, CY; Whellan, DJ. Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998. American Heart Journal. 1998;136:176-179.
(1998)
Abstract
Alexander, JH; Harrington, RA. Recent antiplatelet drug trials in the acute coronary syndromes. Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT. Drugs. 1998;56:965-976.
(1998)
Abstract
O'Neill, GF; Alexander, JH. Spontaneous bladder rupture in a patient with widespread superficial transitional cell carcinoma. ANZ Journal of Surgery. 1998;68:79.
(1998)
Abstract
Alexander, JH; Harrington, RA. Adjunctive Antiplatelet Therapy in Acute Myocardial Infarction: The Road to Improved Infarct-Related Artery Patency. Journal of Thrombosis and Thrombolysis. 1997;4:353-355.
(1997)
Abstract
Alexander, JH; Harrington, RA. Antiplatelet and antithrombin therapies in the acute coronary syndromes. Current Opinion in Cardiology. 1997;12:427-437.
(1997)
Abstract
