Physicians

Division Chief, Pediatric Cardiology

Departments / Divisions

• Pediatrics / Pediatrics-Cardiology
• Medicine / Medicine - Cardiology

Address
DUMC 3090
Durham, NC 27710

Appointment Telephone
919-668-4000

Office Telephone
919-681-2916

Fax Telephone
919-681-0366

Training

• MD, Duke University School of Medicine, 1987

Residency

• Pediatrics, Children's Hospital of Philadelphia (Pennsylvania), 1987-1989
• Pediatrics, Duke University Medical Center, 1989-1990

Fellowship

• Pediatric Cardiology, Duke University Medical Center, 1990-1993

Clinical Interests
Pediatric cardiology, echocardiography, hypertension, hyperlipidemia

Research Interests
1. Pediatric hypertension and hyperlipidemia
2. Clinical trials in children with heart disease
3. Thrombosis in patients with congenital heart disease
4. Enzyme replacement in Pompe disease
5. Infective endocarditis

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Baker-Smith CM, Benjamin DK Jr, Califf RM, Murphy MD, Li JS, Smith PB. Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials. Clin Pharmacol Ther. 2010 Jun;87(6):668-71. (2010) Abstract

Barker GM, O'Brien SM, Welke KF, Jacobs ML, Jacobs JP, Benjamin DK Jr, Peterson ED, Jaggers J, Li JS. Major infection after pediatric cardiac surgery: a risk estimation model. Ann Thorac Surg. 2010 Mar;89(3):843-50. (2010) Abstract

Li JS, Flynn JT, Portman R, Davis I, Ogawa M, Shi H, Pressler ML. The Efficacy and Safety of the Novel Aldosterone Antagonist Eplerenone in Children with Hypertension: A Randomized, Double-Blind, Dose-Response Study. J Pediatr. 2010 Apr 16. (2010) Abstract

Li JS, Newburger JW. Antiplatelet therapy in pediatric cardiovascular patients. Pediatr Cardiol. 2010 May;31(4):454-61. (2010) Abstract

Benjamin DK Jr, Smith PB, Sun MJ, Murphy MD, Avant D, Mathis L, Rodriguez W, Califf RM, Li JS. Safety and transparency of pediatric drug trials. Arch Pediatr Adolesc Med. 2009 Dec;163(12):1080-6. (2009) Abstract

Hsu DT, Mital S, Ravishankar C, Margossian R, Li JS, Sleeper LA, Williams RV, Levine JC, McCrindle BW, Atz AM, Servedio D, Mahony L, . Rationale and design of a trial of angiotensin-converting enzyme inhibition in infants with single ventricle. Am Heart J. 2009 Jan;157(1):37-45. (2009) Abstract

Baker-Smith CM, Benjamin DK Jr, Grabowski HG, Reid ED, Mangum B, Goldsmith JV, Murphy MD, Edwards R, Eisenstein EL, Sun J, Califf RM, Li JS. The economic returns of pediatric clinical trials of antihypertensive drugs. Am Heart J. 2008 Oct;156(4):682-8. (2008) Abstract

Benjamin DK Jr, Smith PB, Jadhav P, Gobburu JV, Murphy MD, Hasselblad V, Baker-Smith C, Califf RM, Li JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008 Apr;51(4):834-40. (2008) Abstract

Levine JC, Kishnani PS, Chen YT, Herlong JR, Li JS. Cardiac remodeling after enzyme replacement therapy with acid alpha-glucosidase for infants with Pompe disease. Pediatr Cardiol. 2008 Nov;29(6):1033-42. (2008) Abstract

Li JS, Baker-Smith CM, Smith PB, Hasselblad V, Murphy MD, Califf RM, Benjamin DK Jr. Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis. Clin Pharmacol Ther. 2008 Sep;84(3):315-9. (2008) Abstract

Li JS, Yow E, Berezny KY, Bokesch PM, Takahashi M, Graham TP Jr, Sanders SP, Sidi D, Bonnet D, Ewert P, Jennings LK, Michelson AD, . Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial. Circulation. 2008 Jan 29;117(4):553-9. (2008) Abstract

McDowell R, Li JS, Benjamin DK Jr, Morgan C, Becker A, Kishnani PS, Kanter RJ. Arrhythmias in patients receiving enzyme replacement therapy for infantile Pompe disease. Genet Med. 2008 Oct;10(10):758-62. (2008) Abstract

Smith PB, Benjamin DK Jr, Murphy MD, Johann-Liang R, Iyasu S, Gould B, Califf RM, Li JS, Rodriguez W. Safety monitoring of drugs receiving pediatric marketing exclusivity. Pediatrics. 2008 Sep;122(3):e628-33. (2008) Abstract

Smith PB, Li JS, Murphy MD, Califf RM, Benjamin DK Jr. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008 Apr;51(4):829-33. (2008) Abstract

Li JS, Eisenstein EL, Grabowski HG, Reid ED, Mangum B, Schulman KA, Goldsmith JV, Murphy MD, Califf RM, Benjamin DK Jr. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA. 2007 Feb 7;297(5):480-8. (2007) Abstract

Li JS, Yow E, Berezny KY, Rhodes JF, Bokesch PM, Charpie JR, Forbus GA, Mahony L, Boshkov L, Lambert V, Bonnet D, Michel-Behnke I, Graham TP, Takahashi M, Jaggers J, Califf RM, Rakhit A, Fontecave S, Sanders SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference? Circulation. 2007 Jul 17;116(3):293-7. (2007) Abstract

McCrindle BW, Li JS, Minich LL, Colan SD, Atz AM, Takahashi M, Vetter VL, Gersony WM, Mitchell PD, Newburger JW, . Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements. Circulation. 2007 Jul 10;116(2):174-9. (2007) Abstract

Minich LL, Sleeper LA, Atz AM, McCrindle BW, Lu M, Colan SD, Printz BF, Klein GL, Sundel RP, Takahashi M, Li JS, Vetter VL, Newburger JW, . Delayed diagnosis of Kawasaki disease: what are the risk factors? Pediatrics. 2007 Dec;120(6):e1434-40. (2007) Abstract

Newburger JW, Sleeper LA, McCrindle BW, Minich LL, Gersony W, Vetter VL, Atz AM, Li JS, Takahashi M, Baker AL, Colan SD, Mitchell PD, Klein GL, Sundel RP, . Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. N Engl J Med. 2007 Feb 15;356(7):663-75. (2007) Abstract

Ansong AK, Li JS, Nozik-Grayck E, Ing R, Kravitz RM, Idriss SF, Kanter RJ, Rice H, Chen YT, Kishnani PS. Electrocardiographic response to enzyme replacement therapy for Pompe disease. Genet Med. 2006 May;8(5):297-301. (2006) Abstract

Benjamin DK Jr, Smith PB, Murphy MD, Roberts R, Mathis L, Avant D, Califf RM, Li JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA. 2006 Sep 13;296(10):1266-73. (2006) Abstract

Cook AL, Kishnani PS, Carboni MP, Kanter RJ, Chen YT, Ansong AK, Kravitz RM, Rice H, Li JS. Ambulatory electrocardiogram analysis in infants treated with recombinant human acid alpha-glucosidase enzyme replacement therapy for Pompe disease. Genet Med. 2006 May;8(5):313-7. (2006) Abstract

Li JS, Jaggers J, Anderson PA. The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. Expert Rev Cardiovasc Ther. 2006 Sep;4(5):649-54. (2006) Abstract

McCrindle BW, Williams RV, Mitchell PD, Hsu DT, Paridon SM, Atz AM, Li JS, Newburger JW, . Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure. Circulation. 2006 Feb 28;113(8):1123-9. (2006) Abstract

Menon S, Berezny KY, Kilaru R, Benjamin DK Jr, Kay JD, Hazan L, Portman R, Hogg R, Deitchman D, Califf RM, Li JS. Racial differences are seen in blood pressure response to fosinopril in hypertensive children. Am Heart J. 2006 Aug;152(2):394-9. (2006) Abstract

Valente AM, Jain R, Scheurer M, Fowler VG Jr, Corey GR, Bengur AR, Sanders S, Li JS. Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia. Pediatrics. 2005 Jan;115(1):e15-9. (2005) Abstract

Li JS, Berezny K, Kilaru R, Hazan L, Portman R, Hogg R, Jenkins RD, Kanani P, Cottrill CM, Mattoo TK, Zharkova L, Kozlova L, Weisman I, Deitchman D, Califf RM. Is the extrapolated adult dose of fosinopril safe and effective in treating hypertensive children? Hypertension. 2004 Sep;44(3):289-93. (2004) Abstract

Li JS, Sanders SP, Perry AE, Stinnett SS, Jaggers J, Bokesch P, Reynolds L, Nassar R, Anderson PA. Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass. Am Heart J. 2004 Jan;147(1):173-80. (2004) Abstract

Milazzo AS Jr, Herlong JR, Li JS, Sanders SP, Barrington M, Bengur AR. Real-time transmission of pediatric echocardiograms using a single ISDN line. Comput Biol Med. 2002 Sep;32(5):379-88. (2002) Abstract

Pasquali SK, Sanders SP, Li JS. Oral antihypertensive trial design and analysis under the pediatric exclusivity provision. Am Heart J. 2002 Oct;144(4):608-14. (2002) Abstract

Milazzo AS Jr, Li JS. Bacterial endocarditis in infants and children. Pediatr Infect Dis J. 2001 Aug;20(8):799-801. (2001) Abstract

Li JS, Sexton DJ, Mick N, Nettles R, Fowler VG Jr, Ryan T, Bashore T, Corey GR. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000 Apr;30(4):633-8. (2000) Abstract

Fowler V, Li JS, Corey GR, Boley J, Gopul AJ, Marr K, Sexton D, Ryan T: Role of echocardiography in patients with staphylococcus aureus bacteremia: experience in 103 patients. J Am Coll Card 1997; 30: 1072-1080. (1997)