Howard A. Rockman, MD
- Medicine / Medicine - Cardiology
- Cell Biology
- Molecular Genetics and Microbiology
Address
DUMC 3104
Durham, NC 27710
Appointment Telephone
919-681-5816
Office Telephone
919-668-2520
Fax Telephone
919-668-2524
- MD, McGill University Faculty of Medicine (Canada), 1983
- Internal Medicine, Montreal General Hospital, (Canada), 1984-1987
- Cardiology, UCSD Medical Center (California), 1987-1989
- Cardiology (Research), UCSD (California), 1989-1991
Clinical Interests
General cardiology, heart failure
Research Interests
Rockman Lab: Molecular Mechanisms of Hypertrophy and Heart Failure
Overall Research Direction: The major focus of this laboratory is to understand the molecular mechanisms of hypertrophy and heart failure. My laboratory uses a strategy that combines state of the art molecular techniques to generate transgenic and gene targeted mouse models, combined with sophisticated physiologic measures of in vivo cardiac function. In this manner, candidate molecules are either selectively overexpressed in the mouse heart or ablated by homologous recombination, which is followed by an in-depth analysis of the physiological phenotype. To model human cardiac disease, we have created several models of cardiac overload in the mouse using both microsurgical techniques and genetic models of cardiac dysfunction.
Areas of Research
1) Signaling: G protein-coupled receptor signaling in hypertrophy and heart failure focusing on the concept of biased signaling of 7 transmembrane receptors.
2) Molecular physiology: In depth physiological analysis of cardiac function in genetically altered mice to understand the role of G protein-coupled receptor signaling pathways on the development of heart failure in vivo.
3) Deletion screens in Drosophila: To detect novel genes important for cardiac function in the adult fly .
This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Trevena Inc.
Representative Publications
Kim IM, Wolf MJ, Rockman HA. Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. Circ Res. 2010 Apr 16;106(7):1233-43.
(2010)
Abstract
Mangmool S, Shukla AK, Rockman HA. {beta}-Arrestin-dependent activation of Ca2+/calmodulin kinase II after {beta}1-adrenergic receptor stimulation. J Cell Biol. 2010 Apr 26.
(2010)
Abstract
Fernandez L, Marchuk DA, Moran JL, Beier DR, Rockman HA. An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. Mamm Genome. 2009 May;20(5):296-304.
(2009)
Abstract
Lima B, Lam GK, Xie L, Diesen DL, Villamizar N, Nienaber J, Messina E, Bowles D, Kontos CD, Hare JM, Stamler JS, Rockman HA. Endogenous S-nitrosothiols protect against myocardial injury. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6297-302.
(2009)
Abstract
Tilley DG, Kim IM, Patel PA, Violin JD, Rockman HA. beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling. J Biol Chem. 2009 Jul 24;284(30):20375-86.
(2009)
Abstract
Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD, Rockman HA. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14555-60.
(2008)
Abstract
Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA. Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest. 2007 Sep;117(9):2445-58.
(2007)
Abstract
Perrino C, Naga Prasad SV, Mao L, Noma T, Yan Z, Kim HS, Smithies O, Rockman HA. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. J Clin Invest. 2006 Jun;116(6):1547-60.
(2006)
Abstract
Wolf MJ, Amrein H, Izatt JA, Choma MA, Reedy MC, Rockman HA. Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1394-9.
(2006)
Abstract
Naga Prasad SV, Jayatilleke A, Madamanchi A, Rockman HA. Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis. Nat Cell Biol. 2005 Aug;7(8):785-96.
(2005)
Abstract
Nienaber JJ, Tachibana H, Naga Prasad SV, Esposito G, Wu D, Mao L, Rockman HA. Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest. 2003 Oct;112(7):1067-79.
(2003)
Abstract
