David H. Harpole Jr., MD
Vice Chief, Division of Surgical Services
Departments / Divisions- Surgery / Cardiovascular & Thoracic
- Pathology
Address
DUMC 3627
Durham, NC 27710
Appointment Telephone
919-668-8413
Office Telephone
919-668-8413
Fax Telephone
919-668-7157
- MD, University of Virginia School of Medicine, 1984
- General Surgery, Duke University Medical Center, 1984-1991
- Thoracic Surgery, Duke University Medical Center, 1991-1993
- Thoracic Oncology, Dana Farber Cancer Institute, Harvard Medical School (Massachusetts), 1993-1995
Clinical Interests
Thoracic oncology; general thoracic surgery; benign and malignant disease of the lung, esophagus, and mediastinum; advanced airway and thoracoscopic surgery; hyperhidrosis palmaris; mesothelioma
Research Interests
A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.
B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Boehringer Ingelheim
- GlaxoSmithKline
Representative Publications
Bailey, SH; Bull, DA; Harpole, DH; Rentz, JJ; Neumayer, LA; Pappas, TN; Daley, J; Henderson, WG; Krasnicka, B; Khuri, SF. Outcomes after esophagectomy: a ten-year prospective cohort. Annals of Thoracic Surgery. 2003;75:217-222.
(2003)
Abstract
Joshi, MB; D'Amico, TA; Harpole, DH. Molecular biologic substaging of stage I NSCLC through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue. Methods in Molecular Medicine. 2003;75:369-388.
(2003)
Abstract
Kinch, MS; Moore, MB; Harpole, DH. Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival. Clinical Cancer Research. 2003;9:613-618.
(2003)
Abstract
D'Amico, TA; Wong, TZ; Harpole, DH; Brown, SD; Coleman, RE. Impact of computed tomography-positron emission tomography fusion in staging patients with thoracic malignancies. Annals of Thoracic Surgery. 2002;74:160-163.
(2002)
Abstract
Lau, CL; Moore, MB; Brooks, KR; D'Amico, TA; Harpole, DH. Molecular staging of lung and esophageal cancer. Surgical Clinics of North America. 2002;82:497-523.
(2002)
Abstract
Toloza, EM; Harpole, DH. Intraoperative techniques to prevent air leaks. Chest Surgery Clinics of North America. 2002;12:489-505.
(2002)
Abstract
Aloia, TA; Harpole, DH; Reed, CE; Allegra, C; Moore, MB; Herndon, JE; D'Amico, TA. Tumor marker expression is predictive of survival in patients with esophageal cancer. Annals of Thoracic Surgery. 2001;72:859-866.
(2001)
Abstract
D'Amico, TA; Aloia, TA; Moore, MB; Conlon, DH; Herndon, JE; Kinch, MS; Harpole, DH. Predicting the sites of metastases from lung cancer using molecular biologic markers. Annals of Thoracic Surgery. 2001;72:1144-1148.
(2001)
Abstract
Harpole, DH; Moore, MB; Herndon, JE; Aloia, T; D'Amico, TA; Sporn, T; Parr, A; Linoila, I; Allegra, C. The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer. Clinical Cancer Research. 2001;7:562-569.
(2001)
Abstract
Kelley, MJ; Li, S; Harpole, DH. Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer. Journal of the National Cancer Institute. 2001;93:1886-1888.
(2001)
Abstract
Marom, EM; Aloia, TA; Moore, MB; Hara, M; Herndon, JE; Harpole, DH; Goodman, PC; Patz, EF. Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer. Lung Cancer. 2001;33:99-107.
(2001)
Abstract
