Director, Cardiac Care Unit

Department / Division:
Medicine / Cardiology

Address:
DUMC 3409
Durham, NC 27710

Appointment Telephone:
919-681-5816

Office Telephone:
919-668-8900

Fax Telephone:
919-668-7056

• MD, University of Connecticut School of Medicine, 1984

• Internal Medicine, University of Colorado Department of Medicine, 1984-1989
• Cardiology, Duke University Medical Center, 1989-1992

Clinical Interests:
Critical care, general inpatient and outpatient cardiology, care of patients with acute and chronic ischemic heart disease, congestive heart failure, valvular heart disease, atrial fibrillation

Research Interests:
Research:
My primary research interest is in conduct and methodology of large randomized clinical trials in heart disease. I have led a number of large international clinical studies in heart attacks, unstable angina, heart failure, and atrial fibrillation.  I have lead clinical studies of blood thinners and coronary intervention for heart attacks, stroke prevention in atrial fibrillation, and prevention of heart attack for patients with coronary artery disease.  I have been co-director of the Reperfusion of Acute MI in Carolina Emergency Departments (RACE) project that is a North Carolina state-wide program to improve reperfusion care for acute myocardial infarction.  I serve as the Vice-Chairman of the American Heart Association Mission: Lifeline program to improve heart attack care nationally.  I have also studied the effects of genetic variation on heart disease.  I work with the National Institute of Health and the Federal Drug Administration on evaluation of heart disease and of new drugs.  I have developed tools to predict which patients are at risk for death, heart attack, and need for hospitalization.

Representative Publications:
Mehta SR, Granger CB, Boden WE, Steg PG, Bassand JP, Faxon DP, Afzal R, Chrolavicius S, Jolly SS, Widimsky P, Avezum A, Rupprecht HJ, Zhu J, Col J, Natarajan MK, Horsman C, Fox KA, Yusuf S, . Early versus delayed invasive intervention in acute coronary syndromes. N Engl J Med. 2009 May 21;360(21):2165-75. (2009) Abstract

Mehta RH, Starr AZ, Lopes RD, Hochman JS, Widimsky P, Pieper KS, Armstrong PW, Granger CB, . Incidence of and outcomes associated with ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention. JAMA. 2009 May 6;301(17):1779-89. (2009) Abstract

Hernandez AF, Granger CB. Advancing care for acute heart failure--no time to relax. Lancet. 2009 Apr 25;373(9673):1401-2. (2009) Abstract

Granger CB. Accelerating ST-segment elevation myocardial infarction care: emergency medical services take center stage. JACC Cardiovasc Interv. 2009 Apr;2(4):347-9. (2009) Abstract

Granger CB, Steg PG, Peterson E, López-Sendón J, Van de Werf F, Kline-Rogers E, Allegrone J, Dabbous OH, Klein W, Fox KA, Eagle KA, . Medication performance measures and mortality following acute coronary syndromes. Am J Med. 2005 Aug;118(8):858-65. (2005) Abstract

Granger CB, McMurray JJ, Yusuf S, Held P, Michelson EL, Olofsson B, Ostergren J, Pfeffer MA, Swedberg K, . Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet. 2003 Sep 6;362(9386):772-6. (2003) Abstract

Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP, Van De Werf F, Avezum A, Goodman SG, Flather MD, Fox KA, . Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003 Oct 27;163(19):2345-53. (2003) Abstract

Granger CB, Becker R, Tracy RP, Califf RM, Topol EJ, Pieper K, Ross A, Roth S, Lambrew C, Bovill EG, for the GUSTO hemostasis substudy group. Thrombin generation, inhibition and clinical outcomes in patients with acute myocardial infarction treated with thrombolytic therapy and heparin: results from the GUSTO trial. J Am Coll Cardiol (in press, 1997). (1997)

Granger CB, Hirsh J, Califf RM, Col J, White HD, Betriu A, Woodlief LH, Lee KL, Bovill E, Simes RJ, Topol EJ, for the GUSTO Trial Investigators. Activated partial thromboplastin time and outcome after thrombolytic therapy for acute myocardial infarction: results from the GUSTO Trial. Circulation 1996;93:870-88. (1996)

Granger CB, Miller JM, Bovill EG, Gruber A, Tracy RP, Berrios E, Green C, Krucoff M, Harrington RA, Ohman EM, Califf RM. Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes. Circulation 1995;91:1929-35. (1995)

Granger CB, White H, Bates E, Ohman EM, Califf RM. A pooled analysis of coronary arterial patency and left ventricular function after intravenous thrombolysis for acute myocardial infarction. Am J Cardiol 1994;74:1220-28. (1994)

Granger CB, Califf RM, Young S, Candela R, Samaha J, Worley S, Kereiakes DJ, Topol EJ, and the TAMI Study Group. Outcomes of patients with diabetes mellitus and acute myocardial infarction treated with thrombolytic therapy. J Am Coll Cardiol 1993;21:920-925. (1993)