Physicians

Chief, Division of Neurosurgery
Deputy Director, The Preston Robert Tisch Brain Tumor Center and Preuss Lab
Guy L. Odom Professor of Neurological Surgery

Department / Division
Surgery / Neurosurgery

Address
DUMC 3807
Durham, NC 27710

Appointment Telephone
919-681-6421

Office Telephone
919-681-6421

Fax Telephone
919-681-7872

Training

• MD, University of Illinois College of Medicine, 1974

Residency

• Neurosurgery, Duke University Medical Center, 1974-1980
• Vascular Surgery, University of Western Ontario (Canada), 1980

Clinical Interests
Brain tumors, skull-base tumors, peripheral nerve surgery, pituitary tumors

Research Interests
At the present time, I am participating in collaborative research in the areas of primary malignant brain tumors, epilepsy and subarachnoid hemorrhage.

Primary malignant brain tumors are increasing in frequency. Patients harboring glioblastoma, the most malignant primary brain tumor, have a life expectancy of less than one year. In colloboration with the Division of Neurology and the Department of Pathology, clinical and laboratory trials have been initiated to identify better treatment for this condition. At present, trials of monoclonal antibodies and novel chemotherapeutic agents are being carried out.

Although physicians have been interested in seizures since the time of Hippocrates, the origin of seizures remains obscure. At Duke University we have treated approximately thirty seizure patients a year by removing abnormal portions of brain. Tissue from these resections is being analyzed for genetics and receptor abnormalities. Positron emission tomography and magnetic resonance imaging are being used to ferret out the origin of the patient's seizures.

Approximately 28,000 patients each year suffer a ruptured intracranial aneurysm. Approximately ten percent of these patients have a genetic predisposition to forming intracranial aneurysms. In conjunction with the Division of Neurology, we are screening candidate genes searching for the cause of intracranial aneurysms.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Kusumi, M; Fukushima, T; Mehta, AI; Aliabadi, H; Nonaka, Y; Friedman, AH; Fujii, K. Tentorial detachment technique in the combined petrosal approach for petroclival meningiomas. Journal of Neurosurgery. 2012;116:566-573. (2012) Abstract

Reardon, DA; Desjardins, A; Peters, KB; Gururangan, S; Sampson, JH; McLendon, RE; Herndon, JE; Bulusu, A; Threatt, S; Friedman, AH; Vredenburgh, JJ; Friedman, HS. Phase II study of carboplatin, irinotecan, and bevacizumab for bevacizumab naïve, recurrent glioblastoma. Journal of Neuro-Oncology. 2012;107:155-164. (2012) Abstract

Wanibuchi, M; Fukushima, T; Zomordi, AR; Nonaka, Y; Friedman, AH. Trigeminal schwannomas: skull base approaches and operative results in 105 patients. Neurosurgery. 2012;70:132-143. (2012) Abstract

Nonaka, Y; Grossi, PM; Bulsara, KR; Taniguchi, RM; Friedman, AH; Fukushima, T. Microsurgical management of hypoglossal schwannomas over 3 decades: a modified grading scale to guide surgical approach. Neurosurgery. 2011;69:ons121-ons140. (2011) Abstract

Reardon, DA; Desjardins, A; Peters, K; Gururangan, S; Sampson, J; Rich, JN; McLendon, R; Herndon, JE; Marcello, J; Threatt, S; Friedman, AH; Vredenburgh, JJ; Friedman, HS. Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. Journal of Neuro-Oncology. 2011;103:371-379. (2011) Abstract

Sampson, JH; Aldape, KD; Archer, GE; Coan, A; Desjardins, A; Friedman, AH; Friedman, HS; Gilbert, MR; Herndon, JE; McLendon, RE; Mitchell, DA; Reardon, DA; Sawaya, R; Schmittling, R; Shi, W; Vredenburgh, JJ; Bigner, DD; Heimberger, AB. Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma. Neuro-Oncology. 2011;13:324-333. (2011) Abstract

Nonaka, Y; Grossi, PM; Filomena, CA; Friedman, AH; Fukushima, T. Unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst. Journal of Neurosurgery. 2010;113:380-383. (2010) Abstract

Sameshima, T; Fukushima, T; McElveen, JT; Friedman, AH. Critical assessment of operative approaches for hearing preservation in small acoustic neuroma surgery: retrosigmoid vs middle fossa approach. Neurosurgery. 2010;67:640-644. (2010) Abstract

Wanibuchi, M; Ohtaki, M; Fukushima, T; Friedman, AH; Houkin, K. Skull base training and education using an artificial skull model created by selective laser sintering. Acta Neurochirurgica: the European journal of neurosurgery. 2010;152:1055-1059. (2010) Abstract

Affronti, ML; Heery, CR; Herndon, JE; Rich, JN; Reardon, DA; Desjardins, A; Vredenburgh, JJ; Friedman, AH; Bigner, DD; Friedman, HS. Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy. Cancer. 2009;115:3501-3511. (2009) Abstract

Friedman, AH; Elias, WJ; Midha, R. Introduction: peripheral nerve surgery--biology, entrapment, and injuries. Neurosurgical Focus. 2009;26:E1. (2009) Abstract

Sampson, JH; Archer, GE; Mitchell, DA; Heimberger, AB; Herndon, JE; Lally-Goss, D; McGehee-Norman, S; Paolino, A; Reardon, DA; Friedman, AH; Friedman, HS; Bigner, DD. An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Molecular Cancer Therapeutics. 2009;8:2773-2779. (2009) Abstract

Wanibuchi, M; Fukushima, T; McElveen, JT; Friedman, AH. Hearing preservation in surgery for large vestibular schwannomas. Journal of Neurosurgery. 2009;111:845-854. (2009) Abstract

Bulsara, KR; Sameshima, T; Friedman, AH; Fukushima, T. Microsurgical management of 53 jugular foramen schwannomas: lessons learned incorporated into a modified grading system. Journal of Neurosurgery. 2008;109:794-803. (2008) Abstract

Desjardins, A; Reardon, DA; Herndon, JE; Marcello, J; Quinn, JA; Rich, JN; Sathornsumetee, S; Gururangan, S; Sampson, J; Bailey, L; Bigner, DD; Friedman, AH; Friedman, HS; Vredenburgh, JJ. Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas. Clinical Cancer Research. 2008;14:7068-7073. (2008) Abstract

Sampson, JH; Akabani, G; Archer, GE; Berger, MS; Coleman, RE; Friedman, AH; Friedman, HS; Greer, K; Herndon, JE; Kunwar, S; McLendon, RE; Paolino, A; Petry, NA; Provenzale, JM; Reardon, DA; Wong, TZ; Zalutsky, MR; Pastan, I; Bigner, DD. Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors. Neuro-Oncology. 2008;10:320-329. (2008) Abstract

Sampson, JH; Akabani, G; Friedman, AH; Bigner, D; Kunwar, S; Berger, MS; Bankiewicz, KS. Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies. Neurosurgical Focus. 2006;20:E14. (2006) Abstract

Little, KM; Friedman, AH; Sampson, JH; Wanibuchi, M; Fukushima, T. Surgical management of petroclival meningiomas: defining resection goals based on risk of neurological morbidity and tumor recurrence rates in 137 patients. Neurosurgery. 2005;56:546-559. (2005) Abstract

Patil, PG; Friedman, AH. Surgical exposure of the sciatic nerve in the gluteal region: anatomic and historical comparison of two approaches. Neurosurgery. 2005;56:165-171. (2005) Abstract

Cokgor, I; Friedman, AH; Friedman, HS. Current options for the treatment of neoplastic meningitis. Journal of Neuro-Oncology. 2002;60:79-88. (2002) Abstract

Heimberger, AB; Archer, GE; Crotty, LE; McLendon, RE; Friedman, AH; Friedman, HS; Bigner, DD; Sampson, JH. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery. 2002;50:158-164. (2002) Abstract

Heimberger, AB; Learn, CA; Archer, GE; McLendon, RE; Chewning, TA; Tuck, FL; Pracyk, JB; Friedman, AH; Friedman, HS; Bigner, DD; Sampson, JH. Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). Clinical Cancer Research. 2002;8:3496-3502. (2002) Abstract

McGirt, MJ; Lynch, JR; Blessing, R; Warner, DS; Friedman, AH; Laskowitz, DT. Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2002;51:1128-1134. (2002) Abstract

Husain, AM; Mendez, M; Friedman, AH. Intractable epilepsy following radiosurgery for arteriovenous malformation. Journal of Neurosurgery. 2001;95:888-892. (2001) Abstract

Little, KM; Friedman, AH; Fukushima, T. Surgical approaches to pineal region tumors. Journal of Neuro-Oncology. 2001;54:287-299. (2001) Abstract