Physicians

Chief, Division of Neurosurgery
Deputy Director, The Preston Robert Tisch Brain Tumor Center and Preuss Lab
Guy L. Odom Professor of Neurological Surgery

Department / Division
Surgery / Neurosurgery

Address
DUMC 3807
Durham, NC 27710

Appointment Telephone
919-681-6421

Office Telephone
919-681-6421

Fax Telephone
919-681-7872

Training

• MD, University of Illinois College of Medicine, 1974

Residency

• Neurosurgery, Duke University Medical Center, 1974-1980
• Vascular Surgery, University of Western Ontario (Canada), 1980

Clinical Interests
Brain tumors, skull-base tumors, peripheral nerve surgery, pituitary tumors

Research Interests
At the present time, I am participating in collaborative research in the areas of primary malignant brain tumors, epilepsy and subarachnoid hemorrhage.

Primary malignant brain tumors are increasing in frequency.  Patients harboring glioblastoma, the most malignant primary brain tumor, have a life expectancy of less than one year.  In colloboration with the Division of Neurology and the Department of Pathology, clinical and laboratory trials have been initiated to identify better treatment for this condition.  At present, trials of monoclonal antibodies and novel chemotherapeutic agents are being carried out.

Although physicians have been interested in seizures since the time of Hippocrates, the origin of seizures remains obscure.  At Duke University we have treated approximately thirty seizure patients a year by removing abnormal portions of brain.  Tissue from these resections is being analyzed for genetics and receptor abnormalities.  Positron emission tomography and magnetic resonance imaging are being used to ferret out the origin of the patient's seizures.

Approximately 28,000 patients each year suffer a ruptured intracranial aneurysm.  Approximately ten percent of these patients have a genetic predisposition to forming intracranial aneurysms.  In conjunction with the Division of Neurology, we are screening candidate genes searching for the cause of intracranial aneurysms.

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Reardon DA, Vredenburgh JJ, Desjardins A, Peters K, Gururangan S, Sampson JH, Marcello J, Herndon JE 2nd, McLendon RE, Janney D, Friedman AH, Bigner DD, Friedman HS. Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma. J Neurooncol. 2011 Jan;101(1):57-66. (2011) Abstract

Nonaka Y, Grossi PM, Filomena CA, Friedman AH, Fukushima T. Unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst. J Neurosurg. 2010 Aug;113(2):380-3. (2010) Abstract

Ohue S, Fukushima T, Kumon Y, Ohnishi T, Friedman AH. Surgical management of brainstem cavernomas: selection of approaches and microsurgical techniques. Neurosurg Rev. 2010 Jul;33(3):315-22; discussion 323-4. (2010) Abstract

Reardon DA, Desjardins A, Peters K, Gururangan S, Sampson J, Rich JN, McLendon R, Herndon JE 2nd, Marcello J, Threatt S, Friedman AH, Vredenburgh JJ, Friedman HS. Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. J Neurooncol. 2010 Sep 19. (2010) Abstract

Sameshima T, Fukushima T, McElveen JT Jr, Friedman AH. Critical assessment of operative approaches for hearing preservation in small acoustic neuroma surgery: retrosigmoid vs middle fossa approach. Neurosurgery. 2010 Sep;67(3):640-4; discussion 644-5. (2010) Abstract

Sampson JH, Aldape KD, Archer GE, Coan A, Desjardins A, Friedman AH, Friedman HS, Gilbert MR, Herndon JE, McLendon RE, Mitchell DA, Reardon DA, Sawaya R, Schmittling R, Shi W, Vredenburgh JJ, Bigner DD, Heimberger AB. Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma. Neuro Oncol. 2010 Dec 10. (2010) Abstract

Sampson JH, Heimberger AB, Archer GE, Aldape KD, Friedman AH, Friedman HS, Gilbert MR, Herndon JE 2nd, McLendon RE, Mitchell DA, Reardon DA, Sawaya R, Schmittling RJ, Shi W, Vredenburgh JJ, Bigner DD. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol. 2010 Nov 1;28(31):4722-9. (2010) Abstract

Wanibuchi M, Ohtaki M, Fukushima T, Friedman AH, Houkin K. Skull base training and education using an artificial skull model created by selective laser sintering. Acta Neurochir (Wien). 2010 Jun;152(6):1055-59; discussion 1059-60. (2010) Abstract

Affronti ML, Heery CR, Herndon JE 2nd, Rich JN, Reardon DA, Desjardins A, Vredenburgh JJ, Friedman AH, Bigner DD, Friedman HS. Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy. Cancer. 2009 Aug 1;115(15):3501-11. (2009) Abstract

Friedman AH, Elias WJ, Midha R. Introduction: peripheral nerve surgery--biology, entrapment, and injuries. Neurosurg Focus. 2009 Feb;26(2):E1. (2009) Abstract

Sampson JH, Archer GE, Mitchell DA, Heimberger AB, Herndon JE 2nd, Lally-Goss D, McGehee-Norman S, Paolino A, Reardon DA, Friedman AH, Friedman HS, Bigner DD. An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Mol Cancer Ther. 2009 Oct;8(10):2773-9. (2009) Abstract

Wanibuchi M, Friedman AH, Fukushima T. Photo Atlas of Skull Base Dissection. Thieme Publishing, Thieme, 2009. (2009)

Wanibuchi M, Fukushima T, McElveen JT, Friedman AH. Hearing preservation in surgery for large vestibular schwannomas. J Neurosurg. 2009 Apr 3. (2009) Abstract

Bulsara KR, Sameshima T, Friedman AH, Fukushima T. Microsurgical management of 53 jugular foramen schwannomas: lessons learned incorporated into a modified grading system.  J Neurosurg.  2008 Nov;109(5):794-803. (2008) Abstract

Desjardins A, Reardon DA, Herndon JE 2nd, Marcello J, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Sampson J, Bailey L, Bigner DD, Friedman AH, Friedman HS, Vredenburgh JJ. Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas.  Clin Cancer Res.  2008 Nov 1;14(21):7068-73. (2008) Abstract

Sampson JH, Akabani G, Archer GE, Berger MS, Coleman RE, Friedman AH, Friedman HS, Greer K, Herndon JE 2nd, Kunwar S, McLendon RE, Paolino A, Petry NA, Provenzale JM, Reardon DA, Wong TZ, Zalutsky MR, Pastan I, Bigner DD. Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.  Neuro Oncol.  2008 Jun;10(3):320-9. (2008) Abstract

Sampson JH, Akabani G, Friedman AH, Bigner D, Kunwar S, Berger MS, Bankiewicz KS. Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies. Neurosurg Focus. 2006;20(4):E14. (2006) Abstract

Little KM, Friedman AH, Sampson JH, Wanibuchi M, Fukushima T. Surgical management of petroclival meningiomas: defining resection goals based on risk of neurological morbidity and tumor recurrence rates in 137 patients.  Neurosurgery.  2005 Mar;56(3):546-59; discussion 546-59. (2005) Abstract

Patil PG, Friedman AH. Surgical exposure of the sciatic nerve in the gluteal region: anatomic and historical comparison of two approaches. Neurosurgery. 2005 Jan;56(1 Suppl):165-71; discussion 165-71. (2005) Abstract

Bulsara KR, Fukushima T, Friedman AH.  Management of malignant tumors of the anterior skull base:  experience with 76 patients.  Neurosurg Focus 13(4):1-11, 2002. (2002)

Cokgor I, Friedman AH, Friedman HS. Current options for the treatment of neoplastic meningitis. J Neurooncol. 2002 Oct;60(1):79-88. (2002) Abstract

Friedman AH, Alexander MJ:  Arterial dissections, in Wilkins R (ed). Neurosurgery, 3rd edition, Chapter 212 (In press) (Book chapter) (2002)

Heimberger AB, Archer GE, Crotty LE, McLendon RE, Friedman AH, Friedman HS, Bigner DD, Sampson JH. Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. Neurosurgery. 2002 Jan;50(1):158-64; discussion 164-6. (2002) Abstract

Heimberger AB, Learn CA, Archer GE, McLendon RE, Chewning TA, Tuck FL, Pracyk JB, Friedman AH, Friedman HS, Bigner DD, Sampson JH. Brain Tumors in Mice Are Susceptible to Blockade of Epidermal Growth Factor Receptor (EGFR) with the Oral, Specific, EGFR-Tyrosine Kinase Inhibitor ZD1839 (Iressa). Clin Cancer Res. 2002 Nov;8(11):3496-502. (2002) Abstract

Little K, Friedman AH:  Postherpetic Neuralgia, in Wilkins R (ed) Neurosurgery, 3rd edition, (In press). (Book chapter) (2002)

McGirt MJ, Lynch JR, Blessing R, Warner DS, Friedman AH, Laskowitz DT. Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2002 Nov;51(5):1128-35. (2002) Abstract

New KC and Friedman AH. "Intramedullary tumors and tumors of the cauda equina" in Principles of Neurosurgery, 2nd edition, eds. Rengachary SS and Ellenbogen R.  Elsevier Science Ltd, London, (in press). (Book chapter) (2002)

New KC and Friedman AH. "Pre- and Post-Operative Management of a Patient with a Ruptured Aneurysm" in Neurosurgery, 3rd edition, eds Rengachary SS and Ellenbogen R.  McGraw-Hill, New York, (in press). (Book chapter) (2002)

Gabriel, E.M., Villavicencio, A.T., Friedman, A.H.: Evaluation and Surgical Repair of Brachial Plexus Injuries. Seminars in Neurosurgery 12 (1):29-48, 2001. (2001)

Husain AM, Mendez M, Friedman AH. Intractable epilepsy following radiosurgery for arteriovenous malformation. J Neurosurg. 2001 Nov;95(5):888-92. (2001) Abstract

Little KM, Friedman AH, Fukushima T. Surgical approaches to pineal region tumors. J Neurooncol. 2001 Sep;54(3):287-99. (2001) Abstract

Friedman AH, Gray L. Clinical and radiological findings of spinal dural arteriovenous fistula. Perspectives in Neurological Surgery 3:1-15, 1992. (1992)

Friedman AH, Nunley JA II, Goldner RD, Oakes WJ, Goldner JL, Urbaniak JR. Nerve transposition for the restoration of elbow flexion following brachial plexus avulsion injuries. J Neurosurg 72:59-64, 1990. (1990)

Friedman AH, Nashold BS Jr, Bronec PR. Dorsal root entry zone lesions for the treatment of brachial plexus avulsion injuries: a follow-up study. Neurosurgery 22:369-373, 1988. (1988)