Patty J. Lee, MD
I received my undergraduate and medical degrees from Brown University before completing internship, residency, and fellowship training at Johns Hopkins School of Medicine. I am a physician-scientist with an interest in mechanisms of lung injury and repair. I have developed genetic and gene-editing approaches in the lung to study critical molecular pathways involved in how the lungs respond to and protect themselves against injury. My clinical time is spent taking care of people with general lung diseases and respiratory failure.
Training and Education
Clinical Focus and Research
My overall research interests are in acute and chronic oxidant-induced lung injury and repair, specifically the distinct roles of stress-response pathways depending on the lung compartment or cell type(s) involved and their regulation by the immune system. Using models of inhaled toxins, such as high oxygen concentrations, cigarette smoke, and microbes, we discovered previously unrecognized mechanistic roles for innate immune receptors, TLR4-NLRP3, mitochondrial health, and cell fate, such as death and/or senescence.
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