Chemotherapy With or Without 9-ING-41 for Pancreatic Cancer (Actuate 1801) - Clinical Trial

What is the Purpose of this Study?

Treatment

We are doing this study to find out if and investigational drug called 9-ING-41 (the study drug) is safe and effective for treating pancreatic cancer.

What is the Condition Being Studied?
Objective

Pancreatic Adenocarcinoma

Who Can Participate in the Study?

Key Eligibility

Adults ages 18+ who:
- Are diagnosed with metastatic pancreatic adenocarcinoma
- Have not received any previous cancer treatment

For more information about who can join this study, please contact the study team at 919-668-1861.

Age Group
Adults

What is Involved?

Description

If you choose to join this study, you will:
- Be assigned to get either 9-ING-41 + standard chemotherapy or standard chemotherapy alone
- Get IV infusions of 9-ING-41 every week (if assigned)
- Get IV infusions of chemotherapy drugs nab-paclitaxel and gemcitabine about 3 times per month
- Give blood and urine samples
- Have regular CT or MRI scans

Study Details

Full Title
Actuate 1801: Phase 1/2 Study of 9-ING-41, a Glycogen Synthase Kinase-3 Beta (GSK-3?) Inhibitor, as a Single Agent and Combined with Chemotherapy, in Patients with Refractory Hematologic Malignancies or Solid Tumors
Principal Investigator
Medical Oncologist
Protocol Number
IRB: PRO00112806
NCT: NCT03678883
Phase
Phase I/II
ClinicalTrials.gov
Enrollment Status
Open for Enrollment
Participate