L-Citrulline in Surgery for Congenital Heart Defects - Clinical Trial
What is the Purpose of this Study?
We are doing this study to see if L-citrulline (the study drug) lessens the amount of time spent on mechanical ventilation (an automatic breathing machine) and decreases the amount of other medicines needed after surgery for congenital heart repair.
Congenital Heart Problems
Who Can Participate in the Study?
Children younger than 18 who are scheduled to have cardiopulmonary bypass done at Duke to repair one of the following congenital defects:
- Large unrestrictive ventricular septal defect; OR
- Ostium primum/secundum atrial septal defect; OR
- Partial or complete atrioventricular septal defect
For more information about who can join this study, contact the study team at email@example.com.
What is Involved?
If you agree to have your child join this study, they will:
- Get a random assignment (like a coin flip) to receive the study drug or placebo (an inactive substance)
- Receive 4 doses of the study drug or placebo
- Have blood draws
- Have a phone call with the study team after they go home from the hospital