Spina Bifida with APOE e4 and Correlates of Alzheimer's Disease - Clinical Trial

What is the Purpose of this Study?

Treatment

We want to learn more about people with spina bifida and their risk of developing dementia if they have the APOE e4 gene.

What is the Condition Being Studied?
Objective

Spina Bifida

Who Can Participate in the Study?

Key Eligibility

Children and adults of any age who have spina bifida and are willing to provide a cheek swab for genetic testing.

Adults ages 18+ who currently have a right-sided shunt may be eligible to participate in a sub-study that involves imaging, a blood draw, and cognitive testing.

For more information about who can join this study, contact the study team at brittany.nave@duke.edu or complete our screening survey by clicking the link: https://redcap.duke.edu/redcap/surveys/?s=EHFWRJMNCWNLMJHP

Age Group
Adults

What is Involved?

Description

If you choose to join this study, you will:
- Visit our clinic 1 time
- Have a cheek swab done for genetic testing (APOE e4)
- Fill out a brief survey

Study Details

Full Title
Neuroimaging, neurocognitive and neuropsychiatric correlates of late-life Alzheimer’s disease genetic risk in adults with spina bifida: A pilot investigation
Principal Investigator
Pediatric Neurologist
Protocol Number
IRB: PRO00110391
Phase
Phase Pilot
Enrollment Status
Open for Enrollment
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