HCRN Lun19-427 (Small Cell Lung Cancer) - Clinical Trial

We are doing this study to see if combining chemotherapy (carboplatin and etoposide) with a study drug called atezolizumab can help people with extensive stage small cell lung cancer (SCLC) that has spread to the brain. We want to find out if this experimental drug combination can give patients more time before whole brain radiation is needed.

Small Cell Lung Cancer (SCLC) with untreated Brain Metastases

Adults age 18 or older who:
- Are diagnosed with extensive stage SCLC
- Have untreated, asymptomatic brain metastases

For more information about who can be in this study, please contact the study team.

This study has 2 parts: a screening period and a study dosing period.

If you join this study, during the screening period you will:
- Have blood draws
- Visit the clinic for various tests to see if you're eligible for the dosing period

If you're eligible for the dosing period, you will:
- Have blood draws
- Answer questionnaires
- Have imaging scans (CT and MRI)
- Receive chemotherapy drugs (carboplatin and etoposide) plus the study drug (atezolizumab) once every 3 weeks for 4 cycles (12 weeks total)
-- After the 4 cycles are done, you will receive only atezolizumab once every 3 weeks