Pilot TRF Study (Time-Restricted Feeding) - Clinical Trial

What is the Purpose of this Study?

As people get older they are at higher risk for age-related diseases such as diabetes, cardiovascular disease, dementia, and Alzheimer's Disease.

We are doing this study to learn more about the potential heart and brain health benefits of following an intermittent fasting diet.

What is the Condition Being Studied?

Heart and Metabolic risk factors

Who Can Participate in the Study?

African-American women, 56-70 years old who:
- Have not been diagnosed with mild cognitive impairment, early onset Alzheimer's Disease/dementia
- Are not currently trying to lose weight
- Are not exercising regularly
- Are not currently eating only 1 main meal a day
- Have 2 or more of the following conditions:
---Currently smoking
---High blood pressure
---High cholesterol
---A family history of Alzheimer's Disease/ dementia

For more information about who can be in this study, please contact the study team.

Age Group

What is Involved?

If you choose to join the study, you will:
-Have a clinic visit at the Duke Center for Living, followed by 2 weeks where you will eat as usual
-After those 2 weeks you will follow the Intermittent Fasting diet for 12 weeks, which requires all food to be eaten within an 8-hour time period each day
-Keep a daily diary of what you eat
-Take surveys online
-Weigh yourself weekly
-Take a series of mental health status and performance tests
-Give blood samples
-Have a follow-up visit at the Center for Living at the end

Study Details

Full Title
A Pilot Study: The Impact of Time-Restricted Feeding on Vascular and Neurocognitive Outcomes
Principal Investigator
Yongmei Liu
Protocol Number
IRB: PRO00105923
Phase Pilot
Enrollment Status
Open for Enrollment
Contact the Duke Recruitment Innovation Center