Neoadjuvant Immunotherapy in Brain Metastases - Clinical Trial
What is the Purpose of this Study?
We are doing this study to find out if we can boost the immune system to kill brain cancer cells if we give the immunotherapy agents, Nivolumab and Ipilimumab, before surgery.
Who Can Participate in the Study?
Adults, 18+ who:
-Have 1 to 3 untreated brain metastases that are less than 4cm in size
-Planned for surgical resection and stereotactic radiosurgery (SRS)
-Are taking 4mg or less of daily dexamethasone
-Have not had immunotherapy in the past 3 months
-Are not pregnant
What is Involved?
If you choose to join this study, you will:
-Be randomized (like the flip of a coin) into 1 of 2 groups:
--Group 1 will be given the immunotherapy agents, Nivolumab and Ipilimumab
--Group 2 will not be given the immunotherapy agents, nivolumab and ipilimumab
-Have an Magnetic Resonance Imaging (MRI) scan before your surgery
-Have tests such as a physical exam and blood tests each time you come to Duke
-Have surgery and stereotactic radiosurgery (SRS)
For more information about who can be in this study, please contact the study team.