MEK-NF-201 - Clinical Trial
What is the Purpose of this Study?
We are doing this study to learn more about the study drug (mirdametinib, PD-0325901) and how it treats symptomatic inoperable neurofibromatosis type-1 (NF1)-associated plexiform neurofibromas (PNs).
Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs)
Who Can Participate in the Study?
-Adults and children 2+
-Have a clinical diagnosis of NF1
- Have a target PN that is inoperable
-Has never received therapy with PD-0325901 or any other MEK1/2 inhibitor
For more information about who can participate in this study, please contact the study team.
What is Involved?
If you choose to be in the study, you, or your child, will have a screening visit that will include:
- A blood draw
-Urine test
-Vision Test
-Physical exam
-Electrocardiogram (ECG)-measures your heart
-Echocardiogram (ECHO)-looks at your heart
-Magnetic resonance imaging (MRI)
-Questionnaires
Once you join the study you will:
-Take the study drug (Mirdametinib, PD-0325901) by mouth twice a day for up to 2 years (3 weeks on, 1 week off cycles)
-Come to the clinic once a month for 7 months, then every other month for the rest of the time they are in the study
Study Details
